DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lgr6

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_017209265.2	Gene:	lgr6 / 100330212	-ID:	-	Length:	962	Species:	Danio rerio

Alignment Length:	398	Identity:	101/398 - (25%)
Similarity:	159/398 - (39%)	Gaps:	95/398 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 QCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRL 230
            ||:...:.||  ::.....|.:....:.|....|.|:.|.:.::..||||.||.|.||:||||.|
Zfish    34 QCEEDGILLL--VDCSEQGLSSVPTDLSPLTSYLDLSMNNISEIQPNAFRNLHFLSELRLSGNHL 96

  Fly   231 SSIGLETFQPLAQLRKLNLSQNALDAL-------RPNVFG------------------------- 263
            ..|.....|.|..|:.|.|..|.|:.|       .||:..
Zfish    97 RHIPGPMLQGLYNLKVLMLQNNQLERLPSEDPWELPNLLSLRLDANLIMEVPARTLSGMRSLRHL 161

  Fly   264 ------------AVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVG 316
                        :..|.:..||.:.|:.|||.|:.|..||.|:.|.:|.:..|.|.:|....|.|
Zfish   162 WLDDNALTEIPVSALNDLSSLQAMTLALNRITLIPDYAFRNLSNLVVLHLHNNMIRTLGQNCFEG 226

  Fly   317 LGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNT--------------- 366
            |.||..|.|.:|.:.|. |.....|..|..|....||::.:.|:.|.||.
Zfish   227 LHSLETLELNFNDLQEF-PVAIRTLAKLQELGFHNNNIKAIPERAFVGNPLLQTIHFYENPIQFV 290

  Fly   367 -------LPRMRRLNLNGN---------------RMKHLHPLAFSSLPF--------LEYLKLGH 401
                   ||::..|:|||.               ::..|.....:|||:        |:.|:|.|
Zfish   291 GRSAFQFLPKLHTLSLNGATEIREFPDLKGTTSLQVLTLTRAGLTSLPYDLCHLLPKLKVLELSH 355

  Fly   402 NELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFL-AKVNVSFPNL 465
            |.::.|.  .|.....||::.|.|||:::|.::..:.|.|::.:.:..|.:..: .....|..:|
Zfish   356 NVIEELP--SFYHCTSLQEIGLQHNLIKQIEMNTFQQLGSLRSLDLSWNSINSIHPDAFFSLQSL 418

  Fly   466 KRVAIEGN 473
            .::.:.||
Zfish   419 IKLDLTGN 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	31/89 (35%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	5/28 (18%)
		LRR_RI	194..455	CDD:238064	92/349 (26%)
		LRR_8	194..254	CDD:290566	25/59 (42%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	11/22 (50%)
		leucine-rich repeat	244..267	CDD:275380	8/66 (12%)
		LRR_8	271..330	CDD:290566	24/58 (41%)
		leucine-rich repeat	272..295	CDD:275380	11/22 (50%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	22/97 (23%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	9/46 (20%)
		LRR_8	368..428	CDD:290566	21/82 (26%)
		leucine-rich repeat	370..393	CDD:275380	7/37 (19%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
lgr6	XP_017209265.2	LRRNT	28..64	CDD:214470	6/31 (19%)
		PLN00113	53..>448	CDD:331614	96/377 (25%)
		leucine-rich repeat	62..85	CDD:275380	8/22 (36%)
		leucine-rich repeat	86..109	CDD:275380	11/22 (50%)
		leucine-rich repeat	110..133	CDD:275380	6/22 (27%)
		leucine-rich repeat	134..157	CDD:275380	0/22 (0%)
		leucine-rich repeat	158..181	CDD:275380	1/22 (5%)
		leucine-rich repeat	182..205	CDD:275380	11/22 (50%)
		leucine-rich repeat	206..229	CDD:275380	8/22 (36%)
		leucine-rich repeat	230..252	CDD:275380	7/22 (32%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..298	CDD:275380	0/20 (0%)
		leucine-rich repeat	324..338	CDD:275378	2/13 (15%)
		leucine-rich repeat	348..369	CDD:275380	7/22 (32%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	2/22 (9%)
		leucine-rich repeat	418..438	CDD:275380	3/9 (33%)
		7tmA_LGR6	554..829	CDD:320484
		TM helix 1	555..581	CDD:320484
		TM helix 2	588..613	CDD:320484
		TM helix 3	633..663	CDD:320484
		TM helix 4	675..697	CDD:320484
		TM helix 5	719..748	CDD:320484
		TM helix 6	757..787	CDD:320484
		TM helix 7	797..822	CDD:320484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910