DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lrrn1-like

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001106456.1	Gene:	lrrn1-like / 100127637	XenbaseID:	XB-GENE-492890	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	482	Identity:	120/482 - (24%)
Similarity:	185/482 - (38%)	Gaps:	128/482 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LWL-LCMGFPILHGA-----DLCQPIGWRNFQCSEVASLQDLVDLGAENWHTLAIRNVQTELEVG 71
            ||: .|:...:||..     .:|.|      ||  |...:.        |.|
Frog    16 LWMETCLFVIVLHSVFFSTLGVCPP------QC--VCETRP--------WFT------------- 51

  Fly    72 SGENADHLANLLDLD--LTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPE----SAL 130
             .::..|.|..:|.:  |....|.|:.|: ..:|  |.|.|         :.:|...|    |.|
Frog    52 -PQSVYHEAKTVDCNDLLLTHIPENLSTD-IQVL--LLQSN---------KISHLTWELQELSNL 103

  Fly   131 QRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQ 195
            ..:|.|.|..:.:|.....||.:||......|.|::     :|..:..:||             .
Frog   104 TELDLSQNHFQSIDDLGVSNLSQLITLYLEENQLRE-----LPDYSLKDLG-------------S 150

  Fly   196 LQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPN 260
            |:||.:|.||:..:...||.||..||.|.|:.|||..|....|:.|..|..|.:.:|.:.||:..
Frog   151 LEELYINHNQISYIGPRAFSGLGRLLRLHLNANRLEIIDPRWFEDLPNLEILMVGENPVTALQSL 215

  Fly   261 VFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYL 325
            .|..:.    .|..|.|:|..:..:.:|.|:.|..|:.|....|.:..:.......|..|:.|.|
Frog   216 NFQPLG----RLHSLVLAGMELEHIPENAFQGLDYLESLSFFDNRLTEVPKEALKNLKLLKFLDL 276

  Fly   326 QYNAILEIKPATFAALLNLDTLDL-SYNNLEFLEEQIFGGNTLPRMRRLNL-NGNRMKHLHPLAF 388
            ..|.|.||:...|..:.:|:.|.| |...||.:|.:.|  ..||.:.:|.: |..|:.:|.|.||
Frog   277 NKNPIPEIRGGDFTGMEHLEELSLNSMEELERVEAEAF--QDLPELIKLEMCNNPRLSYLDPEAF 339

  Fly   389 SSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLT 453
            ||                                         ||..|::|      |::||||.
Frog   340 SS-----------------------------------------NLGALKTL------LLNNNRLA 357

  Fly   454 FL-AKVNVSFPNLKRVAIEGNPWQCPC 479
            .: .|:..:.|.|..:::..||.:|.|
Frog   358 MVPLKIFQALPGLLEISLYSNPIRCDC 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	44/156 (28%)
		LRR_8	104..164	CDD:290566	16/63 (25%)
		leucine-rich repeat	106..129	CDD:275380	5/26 (19%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	7/40 (18%)
		LRR_RI	194..455	CDD:238064	73/262 (28%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	15/58 (26%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		LRR_8	319..380	CDD:290566	20/62 (32%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	9/25 (36%)
		LRR_8	368..428	CDD:290566	10/60 (17%)
		leucine-rich repeat	370..393	CDD:275380	9/23 (39%)
		leucine-rich repeat	394..417	CDD:275380	0/22 (0%)
		leucine-rich repeat	418..441	CDD:275380	4/22 (18%)
lrrn1-like	NP_001106456.1	NEL	<52..>262	CDD:330839	64/243 (26%)
		leucine-rich repeat	60..79	CDD:275380	4/18 (22%)
		leucine-rich repeat	80..102	CDD:275380	6/32 (19%)
		LRR_8	101..161	CDD:316378	20/77 (26%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		leucine-rich repeat	127..150	CDD:275380	7/40 (18%)
		leucine-rich repeat	151..174	CDD:275380	10/22 (45%)
		leucine-rich repeat	175..198	CDD:275380	10/22 (45%)
		leucine-rich repeat	199..222	CDD:275380	6/26 (23%)
		leucine-rich repeat	223..246	CDD:275380	7/22 (32%)
		leucine-rich repeat	247..294	CDD:275380	12/46 (26%)
		LRR_8	294..356	CDD:316378	26/110 (24%)
		leucine-rich repeat	295..319	CDD:275380	9/25 (36%)
		leucine-rich repeat	320..345	CDD:275380	11/65 (17%)
		leucine-rich repeat	346..367	CDD:275380	8/26 (31%)
		PCC	351..>412	CDD:188093	11/34 (32%)
		leucine-rich repeat	370..382	CDD:275378	3/11 (27%)
		Ig	448..515	CDD:319273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910