DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LAMB3 and LanB1

DIOPT Version :9

Sequence 1:NP_000219.2 Gene:LAMB3 / 3914 HGNCID:6490 Length:1172 Species:Homo sapiens
Sequence 2:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster


Alignment Length:1785 Identity:373/1785 - (20%)
Similarity:595/1785 - (33%) Gaps:681/1785 - (38%)


- Green bases have known domain annotations that are detailed below.


Human    21 CSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCDSRQ--PHN-YYSHRV 82
            |.|.:|||..|:||:||...|.|||||||..||.:|........||..||:|:  .|: |.:||:
  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQDKKCFLCDTREETKHDPYKNHRI 113

Human    83 ENVASSSGP----MRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTW 143
            ..:...:.|    ..||||:|.....::||||:..|....:::.|....||.|.||||.|||:||
  Fly   114 GQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQTW 178

Human   144 RVYQYLAADCTSTFPRVRQGRP---QSWQDVRCQSLPQRPNARLNGGKV------QLNLMDLVSG 199
            .:|:|.|.||..:||    |.|   ::..||.|.|.........||..:      .:|:.|    
  Fly   179 HIYRYFAYDCKESFP----GVPTVLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTD---- 235

Human   200 IPATQSQKIQEVGEITNLRVNFTRLAP-----VPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRC 259
               ..::.:|...::||||:..|:|..     :..|..:....||.:|.:.::|||.|:|||.:|
  Fly   236 ---PYAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQC 297

Human   260 AP-KPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSE 323
            .| .|..|...:....||..|.|.|||.|.|||.|..|:|:.||:||.|:..:.|::|:||.|:.
  Fly   298 LPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAV 362

Human   324 TCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDP----- 383
            :||||.|||.||....|||||||..:|.|::||.|..:::|:.....:.:..|..|:|||     
  Fly   363 SCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSD 427

Human   384 -----------DGAVPGA---------------------------------PCDPV--------- 395
                       :|||.||                                 .|:|:         
  Fly   428 DGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGCV 492

Human   396 --TGQCVCKEHVQGERCDLCKP------------------------------------------- 415
              ||:|.||::|.|:.|:.|.|                                           
  Fly   493 MRTGECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGR 557

Human   416 --------------------------------------------GFTGL---------------- 420
                                                        .|||:                
  Fly   558 SCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFTVG 622

Human   421 ----------------------------------------------------------------- 420
                                                                             
  Fly   623 DIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQV 687

Human   421 ----------------------------------------------------------------- 420
                                                                             
  Fly   688 VALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDYE 752

Human   421 ----------------------------------------------------------------- 420
                                                                             
  Fly   753 KYNCKSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGR 817

Human   421 --------TYA-NPQGCHRCDCNILGSRR-----------------------------DMP---- 443
                    ||. .|:||..||||.:||:.                             :.|    
  Fly   818 QCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECRV 882

Human   444 ----------------------------------------------------------------- 443
                                                                             
  Fly   883 CQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHAD 947

Human   444 ---------------------------------------------------------CDEESGRC 451
                                                                     ||.::|.|
  Fly   948 GCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDNGGTCSKCECSNNVDLYDTGNCDRQTGAC 1012

Human   452 L----------------------------------------------------CLPNVVGPKCDQ 464
            |                                                    |||||.|.:|||
  Fly  1013 LKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCDQ 1077

Human   465 CAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVAT 529
            ||..|||:|||:|||.|.|||..:|..|||.:||||.|:.||||..|:     ||....:|:...
  Fly  1078 CAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACN-----QCQAHYWGNPNE 1137

Human   530 GCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLRE 594
            .|:.|:||..|.....||:.:|.|:|..|:.|.:|::|.|||..::|.|..|..||..:|     
  Fly  1138 KCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWD----- 1197

Human   595 QALRFGRLRNA-TASLWSGPGLEDRG----LASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASA 654
              |....|.:| ||::.....::..|    ..|...:...|::.||.:|.:.:|:..::.::...
  Fly  1198 --LILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYE 1260

Human   655 ILSLRRTLQGLQLDLPLEEE-------TLSLPR-DLESLDRSFNGLLTMYQRKREQFEKISSADP 711
            ..|||..||.....|...|:       :|||.. :||||......:..:.:..:|...::..::.
  Fly  1261 TQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRLVQQLSKELKENGIQLQESNI 1325

Human   712 SGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVR---------QAGGGGGTGSPKL 767
            .||..:...|||       :||:.|.|.|:..:.....:|..:         ||.......:.||
  Fly  1326 EGALNLTRHAYE-------RVSNLSTLKDEANELASNTDRNCKRVENLSNKIQAEADDLANNNKL 1383

Human   768 VA-LRLEMSSLPDLTPTF-NKLCGNSRQMACTPISCPGELCPQ-DNGTACGSRCRGVLPRAGGA- 828
            :. .|.|::||....|.. |::||.           ||:.|.. ..|..|| .|.|.|....|| 
  Fly  1384 IEDYRAELTSLTSQIPELNNQVCGK-----------PGDPCDSLCGGAGCG-HCGGFLSCEHGAK 1436

Human   829 -----FLMAGQVAEQLRGFNAQLQRTRQMIRA---AEESASQIQSSAQRLETQVSASRSQMEEDV 885
                 .|...:.||  ....::..:..|.|||   |:.:||:....|:|...|.....:|...::
  Fly  1437 THSEEALKVAKDAE--TAITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNANI 1499

Human   886 RRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLS 950
            :....|...:.:|..:.....:..:|:::..|.|.|..:...:....::|....:.|.||:.::.
  Fly  1500 KLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIY 1564

Human   951 QTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRV 1015
            :||.|:.|...||:.|...:.:|..:......||.:|.....:..:|:|.:|..:.::.|....:
  Fly  1565 RTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDL 1629

Human  1016 AEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1080
            .::.:....||....:..:|:.....::::|::...:...:|.:..:.|.....:|:.|:.....
  Fly  1630 EKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANN 1694

Human  1081 IKQKYA----ELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAIM 1141
            ::...:    .|.||..:|....|   |.:.:...|.:|..:|...:..:.|::...|..:|.::
  Fly  1695 LQSATSATNQTLTDRASRSENARE---RAKQLLQRASKLTVDTNAKLKDLNDLQTVYLNKNQQLL 1756

Human  1142 LRSADLTGLEKRVEQIRDHINGRVLYYATC 1171
            ...|::..|.|.:.:...||..|..:|..|
  Fly  1757 RLQAEIGPLNKELNEHLIHIKERGSHYRQC 1786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMB3NP_000219.2 LamNT 20..248 CDD:214532 82/247 (33%)
EGF_Lam 249..304 CDD:238012 26/55 (47%)
EGF_Lam 315..369 CDD:238012 26/53 (49%)
Laminin_EGF 379..428 CDD:278482 27/415 (7%)
Laminin_EGF 431..478 CDD:278482 29/253 (11%)
Laminin_EGF 481..534 CDD:278482 22/52 (42%)
EGF_Lam 534..576 CDD:214543 16/41 (39%)
Domain II 579..785 51/229 (22%)
Domain alpha 786..816 7/30 (23%)
Domain I 817..1170 71/365 (19%)
MA 844..1071 CDD:214599 42/229 (18%)
MCP_signal 862..1076 CDD:304920 37/213 (17%)
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 74/233 (32%)
EGF_Lam 287..343 CDD:238012 26/55 (47%)
Laminin_EGF 355..415 CDD:278482 26/59 (44%)
Laminin_EGF 418..475 CDD:278482 9/56 (16%)
EGF_Lam 477..526 CDD:238012 12/48 (25%)
EGF_Lam 529..567 CDD:214543 0/37 (0%)
EGF_Lam 789..834 CDD:214543 3/44 (7%)
Laminin_EGF 837..885 CDD:278482 7/47 (15%)
Laminin_EGF 883..930 CDD:278482 0/46 (0%)
Laminin_EGF 933..988 CDD:278482 0/54 (0%)
Laminin_EGF 991..1043 CDD:278482 5/51 (10%)
Laminin_EGF 1043..1091 CDD:278482 17/47 (36%)
Laminin_EGF 1094..1142 CDD:278482 22/52 (42%)
Laminin_EGF 1142..1190 CDD:278482 18/47 (38%)
COG6 1212..>1398 CDD:303003 41/192 (21%)
TelA 1439..1782 CDD:226371 65/347 (19%)
ApoLp-III_like 1545..1702 CDD:304399 27/156 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10659
eggNOG 1 0.900 - - E1_KOG0994
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.910

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