Protein Alignment SH3PX1 and Snx2

DIOPT Version :9

• Sequence 1: NP_648348.1
• Gene: SH3PX1 / 39136
• FlyBaseID: FBgn0040475
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_001344392.1
• Gene: Snx2 / 67804
• MGIID: 1915054
• Length: 523
• Species: Mus musculus
• Alignment Length: 587
• Identity: 116/587 - (19%)
• Similarity: 203/587 - (34%)
• Gaps: 174/587 - (29%)

  Fly    53 PAAYVEVMSAAEAQKLSASGATSVPQVPDPFASPPLPRYDQTADDDGSN-----WDDEDDWSDDN 112
            |..:.|:....:....:.|...|.|..|:|.:   ||..|.:|:.:||.     .||     |..
Mouse    15 PTDFEELEDGEDLFTSTVSTLESSPSSPEPAS---LPAEDISANSNGSKPVEVVLDD-----DRE 71

  Fly   113 DTYSEIGPGGQKSAGQSARAGGLSHSTSDYDNKHLP---IAPNDDTQSLASVAGGTGAAGTVKKG 174
            |.::|...  :.|.....|...||...|.......|   |||..:::|:::..
Mouse    72 DLFAEATE--EVSLDSPERELILSSEPSPAVTPVTPTTLIAPRIESKSISAPV------------ 122

  Fly   175 MFAKSSDSYILGLSSTKEKIPECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFI 239
            :|.:|.|           :|.|.....|..:|              :.|:.|:|..  .||..::
Mouse   123 IFDRSRD-----------EIEEEANGDIFDIE--------------IGVSDPEKVG--DGMNAYM 160

  Fly   240 AYQLTP-------SFNNISVSRRYKHFDWLHERLVDKFCLIP--VPPLPDKQISGRYE------- 288
            ||::|.       |.:..||.||:..|..||.:|..|:..:.  |||.|:|.|.|..:
Mouse   161 AYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKED 225

  Fly   289 ---EQFVEHRRVQLQEFVDWVCRHPVISKCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLA 350
               .:|||.||..|:.::....:||.:
Mouse   226 SSSTEFVEKRRAALERYLQRTVKHPTL-------------------------------------- 252

  Fly   351 ISPPD-KNLLHSK-----VDAQVELGTQFIHSMDVAVRNLNNISNDMAKRS--MSQSKKEFQRIG 407
            :..|| :..|.|.     |:.|...|...:..::.|...:|.::..|.:..  ..:.:::|:.:.
Mouse   253 LQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLD 317

  Fly   408 DGLSDL---AKALAIDERRAPTRNA---------------VPLSESVGRIGGIFIGIGQAFGDQP 454
            ..|..|   .:||....:......|               ..||.::.::..:...|.|...:|.
Mouse   318 QQLRKLHASVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQA 382

  Fly   455 KHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCE-----KLAGEGRM---NNP------- 504
            ..|:...|:.|..|..::.....:|.......||.:|.:     |...|.:|   |.|
Mouse   383 FADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKRETEAKMMVANKPDKIQQAK 447

  Fly   505 ------------QLHDVNRRTDVVSYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARL 557
                        ::....|..:.:|.|:..|:..|:.||       :|:|.|..||:.:.:|...
Mouse   448 NEIREEIEEWEAKVQQGERDFEQISKTIRKEVGRFEKER-------VKDFKAVIIKYLESLVQTQ 505

  Fly   558 QE 559
            |:
Mouse   506 QQ 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	1/5 (20%)
		PX_SNX9_18_like	219..343	CDD:132772	33/142 (23%)
		BAR_SNX9_like	362..564	CDD:153310	44/250 (18%)
Snx2	NP_001344392.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..62		11/34 (32%)
		Sorting_nexin	<49..112	CDD:308990	17/69 (25%)
		PX_SNX2	142..265	CDD:132815	37/176 (21%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000250|UniProtKB:O60749	278..295		3/16 (19%)
		BAR	283..520	CDD:325158	41/232 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940