DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SH3PX1 and Snx9

DIOPT Version :9

Sequence 1:	NP_648348.1	Gene:	SH3PX1 / 39136	FlyBaseID:	FBgn0040475	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_079940.2	Gene:	Snx9 / 66616	MGIID:	1913866	Length:	595	Species:	Mus musculus

Alignment Length:	623	Identity:	207/623 - (33%)
Similarity:	314/623 - (50%)	Gaps:	98/623 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSYVRAMYDFTGEPGSSELSIATGDVLSVTRSDVGEGWWEGKNARGQIGLFPAAYVEVM----- 60
            |.:..|.||||..|||::||::..|::::||..:||.||.||||.:|:.||.|..|||::
Mouse     1 MATKARVMYDFAAEPGNNELTVTEGEIITVTNPNVGGGWLEGKNNKGEQGLVPTDYVEILPNDGK 65

  Fly    61 --------------------SAAEAQKLSASGATSVPQVPDPFA--SPPLP-----------RYD 92
                                |.|:....||:....|....||:.  :.|.|           |.|
Mouse    66 DPFSCGNSVADQAFLDSLTASTAQTNSSSANSNNQVGGGNDPWTAWNAPKPGNWDSSDAWGSRTD 130

  Fly    93 QTA---DDDGSNWD---------------DEDDWSDDNDTYSEIGPGGQKSAGQSARAGGL--SH 137
            .|:   :...:|||               |:|:|.:|.|......|..:.|  :.|.|||:  .:
Mouse   131 GTSAQRNSSANNWDTGFGHPQAYQGPATGDDDEWDEDWDDPKSSSPYFKDS--EPAEAGGIQRGN 193

  Fly   138 STSDYDNKHLPIAPNDDTQSLASVAGGTGAAGTVKKGMFAKSSDSYILG--LSSTKEKIPECEMA 200
            |.:...:..||:               ....|..|.||     :.|:|.  |:..||||     |
Mouse   194 SRAGASSMKLPL---------------NKFPGFAKPGM-----EQYLLAKQLAKPKEKI-----A 233

  Fly   201 YITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLTPSFNNISVSRRYKHFDWLHER 265
            .|  |.|....|....|.:..|||.|:|.||..|:|::|.|||||:..|.||:.||||||||:||
Mouse   234 II--VGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYER 296

  Fly   266 LVDKF-CLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFVDWVCRHPVISKCEVWYHFLTCRDEKI 329
            |:.|| ..||:|.|||||::||:||:|::.|..:||.::..:|||||:|:.||:..||..||||.
Mouse   297 LLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVVSESEVFQQFLNFRDEKE 361

  Fly   330 WKSGKRKAERDPYMGVNYCLAISP--PDKNLLHSKVDAQVELGTQFIHSMDVAVRNLNNISNDMA 392
            ||:||||||:|..:||.....:.|  ||.:|:  :::.:.:...:|..:||..|:.|..:..:..
Mouse   362 WKTGKRKAEKDELVGVMIFSTMEPEAPDLDLI--EIEQKCDAVGKFTKAMDDGVKELLTVGQEHW 424

  Fly   393 KRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPTRNAVPLSESVGRIGGIFIGIGQAFGDQPKHD 457
            ||......||:|:||..|..||...:....:..|    .|::::...|..:..|.....:|||.|
Mouse   425 KRCTGPLPKEYQKIGKALQSLAAVFSSSGYQGET----DLNDAITEAGKTYEEIASLVAEQPKKD 485

  Fly   458 WIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCEKLAGEGRMNNPQLHDVNRRTDVVSYTVLA 522
            ...|.:..|.|:|.|.|||||...|||||:|.|:.:||....::.......:.:|...:||.:.|
Mouse   486 LHFLMECNHEYKGFLGCFPDIIGAHKGAIEKVKESDKLVATSKITPQDKQTMVKRVGTMSYALQA 550

  Fly   523 ELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQEA 560
            |:.||.|.|.......::.::.:|::||:.:..:|::|
Mouse   551 EMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQA 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	27/54 (50%)
		PX_SNX9_18_like	219..343	CDD:132772	70/124 (56%)
		BAR_SNX9_like	362..564	CDD:153310	56/199 (28%)
Snx9	NP_079940.2	SH3_SNX9	4..60	CDD:212831	28/55 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..199		25/111 (23%)
		Critical for tubulation activity. /evidence=ECO:0000250	201..213		3/26 (12%)
		PX_SNX9	250..375	CDD:132818	70/124 (56%)
		BAR_SNX9	386..595	CDD:153352	59/209 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4335
eggNOG	1	0.900	-	-		E1_KOG2528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351108at33208
OrthoFinder	1	1.000	-	-		FOG0006163
OrthoInspector	1	1.000	-	-		otm43070
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X731
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.910