Protein Alignment SH3PX1 and SNX2

DIOPT Version :10

• Sequence 1: NP_648348.1
• Gene: SH3PX1 / 39136
• FlyBaseID: FBgn0040475
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_003091.2
• Gene: SNX2 / 6643
• HGNCID: 11173
• Length: 519
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 109/577 - (18%)
• Similarity: 204/577 - (35%)
• Gaps: 158/577 - (27%)

  Fly    53 PAAYVEVMSAAEAQKLSASGATSVPQVPDPFASPPLPRYDQTADDDGSNWDDE--DDWSDDNDTY 115
            |..:.::....:....:.|...|.|..|:|.:   ||..|.:|:.:|....:.  ||  |..|.:
Human    15 PTDFEDLEDGEDLFTSTVSTLESSPSSPEPAS---LPAEDISANSNGPKPTEVVLDD--DREDLF 74

  Fly   116 SEIGPGGQKSAGQSARAGGLSHSTSDYDNKHLPIAPNDDTQSLASVAGGTGAAGTVKKGMFAKSS 180
            :|                 .:...|....:..||..::.:.::..|...|..|..::    :||.
Human    75 AE-----------------ATEEVSLDSPEREPILSSEPSPAVTPVTPTTLIAPRIE----SKSM 118

  Fly   181 DSYILGLSSTKEKIPECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLTP 245
            .:.:: ...::|:|.|.....|..:|              :.|:.|:|..  .||..::||::|.
Human   119 SAPVI-FDRSREEIEEEANGDIFDIE--------------IGVSDPEKVG--DGMNAYMAYRVTT 166

  Fly   246 -------SFNNISVSRRYKHFDWLHERLVDKFCLIP--VPPLPDKQISGRYE----------EQF 291
                   |.:..||.||:..|..||.:|..|:..:.  |||.|:|.|.|..:          .:|
Human   167 KTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEF 231

  Fly   292 VEHRRVQLQEFVDWVCRHPVISKCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLAISPPD- 355
            ||.||..|:.::....:||.:                                      :..||
Human   232 VEKRRAALERYLQRTVKHPTL--------------------------------------LQDPDL 258

  Fly   356 KNLLHSK-----VDAQVELGTQFIHSMDVAVRNLNNISNDMAKRS--MSQSKKEFQRIGDGLSDL 413
            :..|.|.     |:.|...|...:..::.|...:|.::..|.:..  ..:.:::|:.:...|..|
Human   259 RQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKL 323

  Fly   414 ---AKALAIDERRAPTRNA---------------VPLSESVGRIGGIFIGIGQAFGDQPKHDWIP 460
               .:||....:......|               ..||.::.::..:...|.|...:|...|:..
Human   324 HVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYM 388

  Fly   461 LSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCE-----KLAGEGRM---NNP------------- 504
            .|:.|..|..::.....:|.......||.:|.:     |...|.:|   |.|
Human   389 FSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREW 453

  Fly   505 --QLHDVNRRTDVVSYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQE 559
              ::....|..:.:|.|:..|:..|:.||       :|:|....||:.:.:|...|:
Human   454 EAKVQQGERDFEQISKTIRKEVGRFEKER-------VKDFKTVIIKYLESLVQTQQQ 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	1/5 (20%)
		PX_SNX9_18_like	219..343	CDD:132772	33/142 (23%)
		BAR_SNX9_like	362..564	CDD:153310	43/246 (17%)
SNX2	NP_003091.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..104		19/110 (17%)
		Sorting_nexin	3..75	CDD:461016	15/64 (23%)
		PX_SNX2	142..265	CDD:132815	37/176 (21%)
		Interaction with RhoG. /evidence=ECO:0000269|PubMed:20604901	260..519		45/251 (18%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000303|PubMed:19816406	278..295		3/16 (19%)
		BAR	283..516	CDD:472257	40/228 (18%)