DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SH3PX1 and snx30

DIOPT Version :9

Sequence 1:	NP_648348.1	Gene:	SH3PX1 / 39136	FlyBaseID:	FBgn0040475	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001016905.1	Gene:	snx30 / 549659	XenbaseID:	XB-GENE-944717	Length:	446	Species:	Xenopus tropicalis

Alignment Length:	547	Identity:	116/547 - (21%)
Similarity:	203/547 - (37%)	Gaps:	153/547 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 MSAAEAQK-LSASGATSVPQVPDPFASPPLPRYDQTADDDGSNWDDEDDWSDDNDTYSEIGPGGQ 123
            ||.:...| |..||..|:..:..|.:..|      :|:||
Frog     1 MSGSSTPKSLPTSGQQSLHDIKHPLSCSP------SAEDD------------------------- 34

  Fly   124 KSAGQSARAGGLSHSTSDYDNKHLPIAPNDDTQSLA----SVAGGTGAAGTVKKGMFAKSSDSYI 184
             :||::...  :..|.|       |..||.:..|||    |:..||.|..:      :.:|.|.:
Frog    35 -AAGENGAV--IIESPS-------PDLPNTEPSSLADKDLSLPNGTPADTS------SPASSSSL 83

  Fly   185 LGLSSTKEKIPECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLT----- 244
            |..               .|::|.:...|::   ..|.|..|||.  ...|:|:|.|:::
Frog    84 LNR---------------LQLDDDLDGETRD---LFVTVDDPKKH--VCTMETYITYRVSTKTTR 128

  Fly   245 -----PSFNNISVSRRYKHFDWLHERLVDKFCLIPVPPLPD----KQISGRYEEQFVEHRRVQLQ 300
                 |.:   |:.|||:.||||..:|.:......:||||:    |.:..|:.|:|||.||..|.
Frog   129 TEFDLPEY---SIRRRYQDFDWLRNKLEETQPTHFIPPLPEKFVVKGVVDRFSEEFVETRRKALD 190

  Fly   301 EFVDWVCRHPVISKCEVWYHFLTCRDEKIWKSG-----KRKAERDPYMGVNYCLAISPPDKNLLH 360
            :|:..:..|||:|..|.:..|||.:|....|..     .:..|...|:...|.|...|.:...:.
Frog   191 KFLKRIADHPVLSFNEHFNVFLTAKDLNSHKKQGITLLSKMGESVRYVTSGYKLRNRPVEFATIT 255

  Fly   361 SKVDA-QVELGTQFIHSMDVAVRNLNNISNDMAKRSMS--QSKKEFQRIGDGLSDLAKALAIDER 422
            ..:|. |::|||            ::.|:..:.|..:.  ...:|:..:....|.|.:.|  :|
Frog   256 DYLDTFQLKLGT------------IDRIAQRIIKEEVEYLMELREYGPVYSTWSGLEREL--NE- 305

  Fly   423 RAPTRNAVPLSESVGRIGGIFIGIGQAFGDQPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQ 487
                    ||......:|.....:.:...|. ..|::|:.....:|.          .:.|..::
Frog   306 --------PLEGVSACVGNCSTALEELTEDM-SEDFLPVIREYMLYS----------ESMKTVLK 351

  Fly   488 KR----------KDCEKLAGEGRMNNPQLHDVNRRTDVV---SYTVLAELTHFKSERDTHLKHTL 539
            ||          .:...|..|.|...|.  ||.:..|.|   :..:.|::..:::.:....:..|
Frog   352 KRDQVQAEYEAKAEAAALKREERSTVPT--DVEKCQDKVECFNADLKADMDRWQNNKRQDFRQLL 414

  Fly   540 KNFIAEQIKFY-------QGVVARLQE 559
            .....:.|::|       :.::..||:
Frog   415 MGMADKNIQYYEKCLTAWESIIPLLQD 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697
		PX_SNX9_18_like	219..343	CDD:132772	44/142 (31%)
		BAR_SNX9_like	362..564	CDD:153310	36/221 (16%)
snx30	NP_001016905.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84		28/129 (22%)
		PX_SNX7_30_like	100..215	CDD:132770	41/119 (34%)
		BAR	199..438	CDD:386243	49/274 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940