DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SH3PX1 and snx33

DIOPT Version :9

Sequence 1:	NP_648348.1	Gene:	SH3PX1 / 39136	FlyBaseID:	FBgn0040475	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001016368.1	Gene:	snx33 / 549122	XenbaseID:	XB-GENE-955365	Length:	549	Species:	Xenopus tropicalis

Alignment Length:	571	Identity:	194/571 - (33%)
Similarity:	312/571 - (54%)	Gaps:	42/571 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSYVRAMYDFTGEPGSSELSIATGDVLSVTRSDVG-EGWWEGKNARGQIGLFPAAYVEVMSAAE 64
            |....||:|.|.|| ...|::|...:.|.:. |||. :||.:|.|:|||.|||||:|||::....
Frog     1 MALKARALYSFQGE-NKEEINILENEELHLF-SDVSLDGWLQGTNSRGQTGLFPASYVEILRPRS 63

  Fly    65 AQ-KLSASGATSVPQVPDPFASPPLPRYDQTADDDGSNWDDEDDWSDDNDTYSEIGPGGQKSAGQ 128
            .. ::..||.|.  ...|   ||....||...:||    ||.|||.|......|  |.|.....:
Frog    64 GSVQVDYSGHTQ--GYTD---SPHQGSYDDDEEDD----DDWDDWDDGQTVVDE--PSGSNGVSR 117

  Fly   129 SARAGGLSHSTSDYDNKHLPIAPNDDTQSLASVAGGTGAAGTV------KKGMFAKSS-DSYILG 186
            |.......:...:|.::..|.....|  |:||     |..|:|      :...|.:|. ::::||
Frog   118 SQLQHHHHYPRPEYTHRPRPALERQD--SIAS-----GKRGSVVGRNLNRFSSFVRSGVEAFVLG 175

  Fly   187 LSSTKEKIPE---CEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLTPSFN 248
                  .:|:   ...::..::.....||..|..|:|..|..|.|::||||:|::|:|:|||...
Frog   176 ------DVPQFGGVSESHAIEMGPKGPQWKANPRPFSCSVEEPTKQTKFKGIKSYISYRLTPDPC 234

  Fly   249 NISVSRRYKHFDWLHERLVDKFCLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFVDWVCRHPVIS 313
            |..|.|||||||||:.||:.||.:|.||.||:||.:||:||.|::.|:.:|..::|.:..|||:|
Frog   235 NSPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIQKRKRRLVLWMDHMTSHPVLS 299

  Fly   314 KCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLAISPPDKNLLHSKVDAQVELGTQFIHSMD 378
            :.:.:.|||:|:|||.||:|||:||||..:|.::.|.:..|.::.....|:.:|::...|...||
Frog   300 QYDGFQHFLSCQDEKQWKAGKRRAERDELVGASFLLTLQLPTEHQDLQDVEERVDVFKAFSKKMD 364

  Fly   379 VAVRNLNNISNDMAKRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPTRNAVPLSESVGRIGGIF 443
            ..|..|:::.:::|::.:...:|||||:|..|..|:.:..:|    |..::.||..::...|..:
Frog   365 ENVLQLSSVVSELARKHLGGFRKEFQRLGAALQGLSHSFQLD----PPYSSEPLVGAISHTGRTY 425

  Fly   444 IGIGQAFGDQPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCEKLAGEGRMNNPQLHD 508
            ..:|:.|.:|||:|.....|.|.:|:|:|:.||||....|||..|.|:.::::.||||...:...
Frog   426 EAVGEMFAEQPKNDQFRFLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRMEQDEADG 490

  Fly   509 VNRRTDVVSYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQE 559
            :.:|..||.:.:.||:.||...|....|..:::::.|||.||:.|...|::
Frog   491 IRKRCRVVGFALQAEINHFHQRRLQDFKQAIQHYLKEQILFYRRVSQELEK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	26/55 (47%)
		PX_SNX9_18_like	219..343	CDD:132772	64/123 (52%)
		BAR_SNX9_like	362..564	CDD:153310	61/198 (31%)
snx33	NP_001016368.1	SH3	4..58	CDD:388381	26/55 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..137		21/81 (26%)
		PX_domain	205..329	CDD:383026	64/123 (52%)
		BAR	340..546	CDD:386243	62/206 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4306
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2458
OMA	1	1.010	-	-		QHG48621
OrthoDB	1	1.010	-	-		D351108at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48199
Panther	1	1.100	-	-	O	PTHR45827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X731
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.110