Protein Alignment SH3PX1 and SNX9

DIOPT Version :10

• Sequence 1: NP_648348.1
• Gene: SH3PX1 / 39136
• FlyBaseID: FBgn0040475
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_057308.1
• Gene: SNX9 / 51429
• HGNCID: 14973
• Length: 595
• Species: Homo sapiens
• Alignment Length: 628
• Identity: 209/628 - (33%)
• Similarity: 313/628 - (49%)
• Gaps: 108/628 - (17%)

  Fly     1 MTSYVRAMYDFTGEPGSSELSIATGDVLSVTRSDVGEGWWEGKNARGQIGLFPAAYVEVM----- 60
            |.:..|.||||..|||::||::..|:::::|..|||.||.||:|.:|:.||.|..|||::
Human     1 MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEILPSDGK 65

  Fly    61 --------------------SAAEAQKLSASGATSVPQVPDPFASPPLPRYDQTADDDG------ 99
                                |.|:|...:||....|....||:::....:.......:|
Human    66 DQFSCGNSVADQAFLDSLSASTAQASSSAASNNHQVGSGNDPWSAWSASKSGNWESSEGWGAQPE 130

  Fly   100 -----------SNWD---------------DEDDWSDDNDTYSEIGPGGQKSA-----GQSARAG 133
                       :|||               |:|||.:|.|        |.||:     .:||.||
Human   131 GAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWD--------GPKSSSYFKDSESADAG 187

  Fly   134 GLSHSTSDYDNKHLPIAPNDDTQSLASVAGGTGAAGTVKKGMFAK-SSDSYILG--LSSTKEKIP 195
            |.....|...:..:.|..|                   |...||| .::.|:|.  |:..|||||
Human   188 GAQRGNSRASSSSMKIPLN-------------------KFPGFAKPGTEQYLLAKQLAKPKEKIP 233

  Fly   196 ECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLTPSFNNISVSRRYKHFD 260
                   ..|.|....|....|.:..|||.|:|.||..|:|::|.|||||:..|.||:.||||||
Human   234 -------IIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFD 291

  Fly   261 WLHERLVDKF-CLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFVDWVCRHPVISKCEVWYHFLTC 324
            ||:|||:.|| ..||:|.|||||::||:||:|::.|..:||.::..:|||||||:.||:..||..
Human   292 WLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNF 356

  Fly   325 RDEKIWKSGKRKAERDPYMGVNYCLAISP--PDKNLLHSKVDAQVELGTQFIHSMDVAVRNLNNI 387
            ||||.||:||||||||...||.....:.|  ||.:|:  :::.:.|...:|..:||..|:.|..:
Human   357 RDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLV--EIEQKCEAVGKFTKAMDDGVKELLTV 419

  Fly   388 SNDMAKRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPTRNAVPLSESVGRIGGIFIGIGQAFGD 452
            ..:..||......||:|:||..|..||...:....:..|    .|::::...|..:..|.....:
Human   420 GQEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGET----DLNDAITEAGKTYEEIASLVAE 480

  Fly   453 QPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCEKLAGEGRMNNPQLHDVNRRTDVVS 517
            |||.|...|.:..|.|:|.|.|||||..||||||:|.|:.:||....::......::.:|..::|
Human   481 QPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKRVSIMS 545

  Fly   518 YTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQEA 560
            |.:.||:.||.|.|.......::.::.:|::||:.:..:|::|
Human   546 YALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQA 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	26/54 (48%)
		PX_SNX9_18_like	219..343	CDD:132772	72/124 (58%)
		BAR_SNX9_like	362..564	CDD:153310	58/199 (29%)
SNX9	NP_057308.1	SH3_SNX9	4..60	CDD:212831	27/55 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..201		24/117 (21%)
		Critical for tubulation activity	201..213		4/30 (13%)
		PX_SNX9	250..375	CDD:132818	72/124 (58%)
		BAR_SNX9	386..595	CDD:153352	61/209 (29%)