DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SH3PX1 and Snx18

DIOPT Version :9

Sequence 1:	NP_648348.1	Gene:	SH3PX1 / 39136	FlyBaseID:	FBgn0040475	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001101122.1	Gene:	Snx18 / 310097	RGDID:	1310367	Length:	615	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	215/633 - (33%)
Similarity:	327/633 - (51%)	Gaps:	98/633 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSYVRAMYDFTGE-PGSSELSIATGDVLSVTRSDVGEGWWEGKNARGQIGLFPAAYVEVMSAAE 64
            |....||:|||..| ||  |:|:...:|||:......|||.||.|:||..|||||:||:|:.|.|
  Rat     1 MALRARALYDFRSENPG--EISLREHEVLSLCSEQDIEGWLEGINSRGDRGLFPASYVQVIRAPE 63

  Fly    65 A--------------QKLSASGATSVPQVP--------DPFASP----------------PLPRY 91
            .              ..:...|...:|..|        .|.|||                |.|..
  Rat    64 PGPPADGGPGAPARYANVPPGGFEPLPAAPPAAFQPLLQPQASPGSFQSPGAGFTYGGGAPQPSP 128

  Fly    92 DQT---------ADDDGSNWDDEDDWSDDNDTYSE----IGPG------GQKSAGQSARAGGLSH 137
            .|.         :|||   ||||  | ||:.|.::    :|.|      |..|||..| ||....
  Rat   129 QQLYGAYQASLGSDDD---WDDE--W-DDSSTVADEPGALGSGAYPDLDGSSSAGGGA-AGRYRL 186

  Fly   138 ST-SDYDNKHLPIAPNDDTQSLASVAGGTGAAGTVKKGM-----FAKS-SDSYILGLSS--TKEK 193
            || ||     |.:.....:......|.|..::.||.:.:     |.|| .::::||.:|  .|:.
  Rat   187 STRSD-----LSLGSRGVSAPPPHQASGAKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDG 246

  Fly   194 IPECEMAYITQVEDSIY--QWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLTPSFNNISVSRRY 256
            ...|       |....|  :|.:|..|:...:..|.|::||||||::|:|:|.|:...:.|.|||
  Rat   247 DKLC-------VVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRY 304

  Fly   257 KHFDWLHERLVDKFCLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFVDWVCRHPVISKCEVWYHF 321
            ||||||:.||.:||.:|.||.||:||.:||:||.|:..||..|..:::.:..|||:::|:|:.||
  Rat   305 KHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHF 369

  Fly   322 LTC---RDEKIWKSGKRKAERDPYMGVNYCLAIS-PPDKNLLHSKVDAQVELGTQFIHSMDVAVR 382
            |||   .|||.||.||||||:|..:|.|:.|.:| ||...|...:|:::::....|...||.:..
  Rat   370 LTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSAL 434

  Fly   383 NLNNISNDMAKRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPTRNAVPLSESVGRIGGIFIGIG 447
            .||:.:|:.|::.::..|||:|::|.....|::|..:|::..    :|.|::::...|..:..||
  Rat   435 QLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAF----SVGLNQAIAFTGDAYDAIG 495

  Fly   448 QAFGDQPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCEKLAGEGRMNNPQLHDVNRR 512
            :.|.:||:.|..|:.|.|.:|:|.|..||||....|||:.|.|:..:...||:|...:...:..|
  Rat   496 ELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGALTKVKESRRHVEEGKMEVQKADGIQDR 560

  Fly   513 TDVVSYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQEA 560
            .:.:|:..|||:.||...|....|..:::|:.:||.|:|.|..:|:||
  Rat   561 CNTISFATLAEIHHFHQIRVRDFKSQMQHFLQQQIIFFQKVTQKLEEA 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	28/55 (51%)
		PX_SNX9_18_like	219..343	CDD:132772	63/126 (50%)
		BAR_SNX9_like	362..564	CDD:153310	61/199 (31%)
Snx18	NP_001101122.1	SH3_SNX18	4..58	CDD:212830	28/55 (51%)
		PX_SNX18	267..394	CDD:132819	63/126 (50%)
		BAR_SNX18	406..612	CDD:153354	63/207 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4247
eggNOG	1	0.900	-	-		E1_KOG2528
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14164
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2394
OMA	1	1.010	-	-		QHG48621
OrthoDB	1	1.010	-	-		D351108at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45135
orthoMCL	1	0.900	-	-		OOG6_104281
Panther	1	1.100	-	-	LDO	PTHR45827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X731
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840