Protein Alignment SH3PX1 and Snx2

DIOPT Version :10

• Sequence 1: NP_648348.1
• Gene: SH3PX1 / 39136
• FlyBaseID: FBgn0040475
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_001099605.2
• Gene: Snx2 / 291464
• RGDID: 1310291
• Length: 519
• Species: Rattus norvegicus
• Alignment Length: 580
• Identity: 111/580 - (19%)
• Similarity: 205/580 - (35%)
• Gaps: 164/580 - (28%)

  Fly    53 PAAYVEVMSAAEAQKLSASGATSVPQVPDPFASPPLPRYDQTADDDGS-----NWDDEDDWSDDN 112
            |..:.|:....:....:.|...|.|..|:|.:   ||..|.:|:.:||     ..||     |..
  Rat    15 PTDFEELEDGEDLFTSTVSTLESSPSSPEPAS---LPAEDISANSNGSRPVEVTLDD-----DRE 71

  Fly   113 DTYSEIGPGGQKSAGQSARAGGLSHSTSDYDNKHLPIAPNDDTQSLASVAGGTGAAGTVKKGMFA 177
            |.::|                 .:...|....:..||..::.:.::..:...|..|..::    :
  Rat    72 DLFAE-----------------ATEEVSLDSPEREPIMSSEPSPAVTPITPTTLIAPRIE----S 115

  Fly   178 KSSDSYILGLSSTKEKIPECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQ 242
            ||..:.:: ...::|:|.|.....|..:|              :.|:.|:|..  .||..::||:
  Rat   116 KSISAPVI-FDRSREEIEEEANGDIFDIE--------------IGVSDPEKVG--DGMNAYMAYR 163

  Fly   243 LTP-------SFNNISVSRRYKHFDWLHERLVDKFCLIP--VPPLPDKQISGRYE---------- 288
            :|.       |.:..||.||:..|..||.:|..|:..:.  |||.|:|.|.|..:
  Rat   164 VTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSS 228

  Fly   289 EQFVEHRRVQLQEFVDWVCRHPVISKCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLAISP 353
            .:|||.||..|:.::....:||.:                                      :..
  Rat   229 TEFVEKRRAALERYLQRTVKHPTL--------------------------------------LQD 255

  Fly   354 PD-KNLLHSK-----VDAQVELGTQFIHSMDVAVRNLNNISNDMAKRS--MSQSKKEFQRIGDGL 410
            || :..|.|.     |:.|...|...:..::.|...:|.::..|.:..  ..:.:::|:.:...|
  Rat   256 PDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQL 320

  Fly   411 SDL---AKALAIDERRAPTRNA---------------VPLSESVGRIGGIFIGIGQAFGDQPKHD 457
            ..|   .:||....:......|               ..||.::.::..:...|.|...:|...|
  Rat   321 RKLHASVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFAD 385

  Fly   458 WIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCE-----KLAGEGRM---NNP---------- 504
            :...|:.|..|..::.....:|.......||.:|.:     |...|.:|   |.|
  Rat   386 FYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKRETEAKMMVANKPDKIQQAKNEI 450

  Fly   505 -----QLHDVNRRTDVVSYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQE 559
                 ::....|..:.:|.|:..|:..|:.||       :|:|.|..||:.:.:|...|:
  Rat   451 REWEAKVQQGERDFEQISKTIRKEVGRFEKER-------VKDFKAVIIKYLESLVQTQQQ 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	1/5 (20%)
		PX_SNX9_18_like	219..343	CDD:132772	33/142 (23%)
		BAR_SNX9_like	362..564	CDD:153310	44/246 (18%)
Snx2	NP_001099605.2	Sorting_nexin	3..75	CDD:461016	17/67 (25%)
		PX_SNX2	142..265	CDD:132815	37/176 (21%)
		BAR	283..516	CDD:472257	41/228 (18%)