Protein Alignment SH3PX1 and SNX33

DIOPT Version :9

• Sequence 1: NP_648348.1
• Gene: SH3PX1 / 39136
• FlyBaseID: FBgn0040475
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_695003.1
• Gene: SNX33 / 257364
• HGNCID: 28468
• Length: 574
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 194/585 - (33%)
• Similarity: 318/585 - (54%)
• Gaps: 43/585 - (7%)

  Fly     6 RAMYDFTGEPGSSELSIATGDVLSVTRSDVGEGWWEGKNARGQIGLFPAAYVEV----MSAAEAQ 66
            ||:|||..| ...|:||...:.|.:......:||.:|:|:||:.|||||:|||:    :|...|.
Human     6 RALYDFHSE-NKEEISIQQDEDLVIFSETSLDGWLQGQNSRGETGLFPASYVEIVRSGISTNHAD 69

  Fly    67 KLSASGATSVPQVPDPFASPPLPRYDQTADDDG--SNW-----DDEDDWSDDNDTYSEIGPGGQK 124
            ..|:...:...|| ..:.||.:....::....|  ||.     ||:|||.|.:|..:.:
Human    70 YSSSPAGSPGAQV-SLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDWDDGCTVV------ 127

  Fly   125 SAGQSARAGGLSHS---------TSDYDNKHL---PIAPNDDTQSLASVAGGTGAAGTVKK-GMF 176
               :..|||||..:         ...|.::|:   |..|.:...||||...|:.....:.: ..|
Human   128 ---EEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVGRNLNRFSCF 189

  Fly   177 AKSS-DSYILGLSSTKEKIPECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIA 240
            .:|. :::|||......||.|   .|..::.....||..|..|::..|..|.|::||||:|::|:
Human   190 VRSGVEAFILGDVPMMAKIAE---TYSIEMGPRGPQWKANPHPFACSVEDPTKQTKFKGIKSYIS 251

  Fly   241 YQLTPSFNNISVSRRYKHFDWLHERLVDKFCLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFVDW 305
            |:|||:.....|.|||||||||:.||:.||.:|.||.||:||.:||:||.|:|.|:.:|..::|.
Human   252 YKLTPTHAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDH 316

  Fly   306 VCRHPVISKCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLAISPPDKNLLHSKVDAQVELG 370
            :..|||:|:.|.:.|||:|.|:|.||.|||:||:|..:|.::.|....|.::.....|:.:|:..
Human   317 MTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTF 381

  Fly   371 TQFIHSMDVAVRNLNNISNDMAKRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPTRNAVPLSES 435
            ..|...||.:|..|:.:::::.::.:...:||||::|.....::.:..:|    |...:..|:.:
Human   382 KAFSKKMDDSVLQLSTVASELVRKHVGGFRKEFQKLGSAFQAISHSFQMD----PPFCSEALNSA 442

  Fly   436 VGRIGGIFIGIGQAFGDQPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCEKLAGEGR 500
            :...|..:..||:.|.:|||:|...:.|.|.:|:|:|:.||||....|||..|.|:.::::.|||
Human   443 ISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGR 507

  Fly   501 MNNPQLHDVNRRTDVVSYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQEASRQIE 565
            |...:...:.||..||.:.:.||:.||...|:...||.::|::.:||.|||.|..:|::..|..:
Human   508 MVQDEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQNYLRQQILFYQRVGQQLEKTLRMYD 572

  Fly   566  565
            Human   573  572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	23/52 (44%)
		PX_SNX9_18_like	219..343	CDD:132772	62/123 (50%)
		BAR_SNX9_like	362..564	CDD:153310	61/201 (30%)
SNX33	NP_695003.1	SH3_SNX33	4..58	CDD:212829	23/52 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..119		14/51 (27%)
		PX_domain	230..354	CDD:295365	62/123 (50%)
		BAR_SNX33	365..571	CDD:153353	62/209 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4413
eggNOG	1	0.900	-	-		E1_KOG2528
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48621
OrthoDB	1	1.010	-	-		D351108at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40999
orthoMCL	1	0.900	-	-		OOG6_104281
Panther	1	1.100	-	-	O	PTHR45827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X731
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.820