Protein Alignment SH3PX1 and SNX18

DIOPT Version :9

• Sequence 1: NP_648348.1
• Gene: SH3PX1 / 39136
• FlyBaseID: FBgn0040475
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_443102.2
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 628
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 194/575 - (33%)
• Similarity: 286/575 - (49%)
• Gaps: 125/575 - (21%)

  Fly     1 MTSYVRAMYDFTGE-PGSSELSIATGDVLSVTRSDVGEGWWEGKNARGQIGLFPAAYVEVMSAAE 64
            |....||:|||..| ||  |:|:...:|||:......|||.||.|:||..|||||:||:|:.|.|
Human     1 MALRARALYDFRSENPG--EISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPE 63

  Fly    65 AQKLSASGA------TSVP-----------------------------QVPDP--FASP------ 86
            .......|.      .:||                             |.|.|  |..|
Human    64 PGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPSTFQPPGAGFPY 128

  Fly    87 ------PLPRY-------DQTADDDGSNWDDEDDWSDDNDTYSE----IGPG------GQKSAGQ 128
                  |.|:.       .|.:|||   ||||  | ||:.|.::    :|.|      |..|||.
Human   129 GGGALQPSPQQLYGGYQASQGSDDD---WDDE--W-DDSSTVADEPGALGSGAYPDLDGSSSAGV 187

  Fly   129 SARAGGLSHST-SDYDNKHLPIAPNDDTQSLASVAG---------GTGAAGTVKKGM-----FAK 178
            .| ||....|| ||.              ||.|..|         |..::.||.:.:     |.|
Human   188 GA-AGRYRLSTRSDL--------------SLGSRGGSVPPQHHPSGPKSSATVSRNLNRFSTFVK 237

  Fly   179 S-SDSYILGLSS--TKEKIPECEMAYITQVEDSIY--QWTQNHSPYSVVVASPKKESKFKGMKTF 238
            | .::::||.:|  .|:....|       |....|  :|.:|..|:...:..|.|::||||||::
Human   238 SGGEAFVLGEASGFVKDGDKLC-------VVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSY 295

  Fly   239 IAYQLTPSFNNISVSRRYKHFDWLHERLVDKFCLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFV 303
            |:|:|.|:...:.|.|||||||||:.||.:||.:|.||.||:||.:||:||.|:..||..|..::
Human   296 ISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWM 360

  Fly   304 DWVCRHPVISKCEVWYHFLTC---RDEKIWKSGKRKAERDPYMGVNYCLAIS-PPDKNLLHSKVD 364
            :.:..|||:::|:|:.|||||   .|||.||.||||||:|..:|.|:.|.:| ||...|...:|:
Human   361 NHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVE 425

  Fly   365 AQVELGTQFIHSMDVAVRNLNNISNDMAKRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPTRNA 429
            ::::....|...||.:...||:.:|:.|::.::..|||:|::|.....|::|..:|::..    :
Human   426 SKIDGFKCFTKKMDDSALQLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAF----S 486

  Fly   430 VPLSESVGRIGGIFIGIGQAFGDQPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKG 484
            |.|::::...|..:..||:.|.:||:.|..|:.|.|.:|:|.|..||||....||
Human   487 VGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKG 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	28/55 (51%)
		PX_SNX9_18_like	219..343	CDD:132772	63/126 (50%)
		BAR_SNX9_like	362..564	CDD:153310	37/123 (30%)
SNX18	NP_443102.2	SH3_SNX18	4..58	CDD:212830	28/55 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..188		29/131 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..224		6/37 (16%)
		PX_SNX18	276..403	CDD:132819	63/126 (50%)
		BAR	415..>541	CDD:299863	37/129 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4413
eggNOG	1	0.900	-	-		E1_KOG2528
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14164
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48621
OrthoDB	1	1.010	-	-		D351108at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104281
Panther	1	1.100	-	-	LDO	PTHR45827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X731
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.820