DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SH3PX1 and snx2

DIOPT Version :9

Sequence 1:	NP_648348.1	Gene:	SH3PX1 / 39136	FlyBaseID:	FBgn0040475	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	XP_012823895.1	Gene:	snx2 / 100492702	XenbaseID:	XB-GENE-5791488	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	109/563 - (19%)
Similarity:	193/563 - (34%)	Gaps:	152/563 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PPLPRYDQTADDDGSNWDDEDDWSDDNDTYS------EIGPGGQKSAGQSARAGGLSHSTSDYDN 144
            |||        .||...:.| |..|..|.::      |..|...:.|...|.    ..||:....
Frog     8 PPL--------GDGRQPECE-DLEDGEDLFTSTVSTLESSPSSPEPASLPAE----DISTNSNGP 59

  Fly   145 KHLPIAPNDDTQSLASVAGGTGAAGTVKKGMFAKSSDS-YILGLSSTKEKIPECEMAYIT----- 203
            |...:...||.:.|.:.|....:..:.::.:...|..| .|..::.|...:|..|...|:
Frog    60 KTTEVLLCDDREDLFAEATDEVSLDSPERDLILSSEPSPAITPVTPTSLIMPRMETISISAPVIY 124

  Fly   204 -----QVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLTP-------SFNNISVSRRY 256
                 ::|:.     .|...:.|.:.....|....||..::||::|.       :.|..||.||:
Frog   125 DRSTDEIEEE-----ANGDAFDVEIGVSDPEKVGDGMNAYMAYKVTTKTSLSMFNKNEFSVRRRF 184

  Fly   257 KHFDWLHERLVDKFCLIP--VPPLPDKQISGRYE----------EQFVEHRRVQLQEFVDWVCRH 309
            ..|..||.:|..|:..|.  |||.|:|.|.|..:          .:|||.||..|:.::....:|
Frog   185 SDFLGLHSKLATKYMHIGYIVPPAPEKSIVGMTKVKVGKEDSSSNEFVEKRRAALERYLQRTVKH 249

  Fly   310 PVISKCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLAISPPD-KNLLHSK-----VDAQVE 368
            |.:                                      :..|| :..|.|.     |..|..
Frog   250 PTL--------------------------------------LQDPDLRQFLESSELPRAVSTQAL 276

  Fly   369 LGTQFIHSMDVAVRNLNNISNDMAKRS--MSQSKKEFQRIGDGLSDL---------------AKA 416
            .|...:..::.|...:|.::..|.:..  ..:.:::|:.:...|..|               |..
Frog   277 SGAGLLRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHGNVESLVCHRKELSANT 341

  Fly   417 LAIDERRAPTRNA---VPLSESVGRIGGIFIGIGQAFGDQPKHDWIPLSDRLHIYRGVLNCFPDI 478
            .|..:..|...|:   ..||.::.::..:...|.|...||...|:...::.|..|..::.....:
Frog   342 AAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQDQAFADFYLFTELLSDYIRLIAAVKGV 406

  Fly   479 FSTHKGAIQKRKDCE-----KLAGEGRM---NNP-------------------QLHDVNRRTDVV 516
            |.......||.:|.:     |...|.::   |.|                   ::....|..|.:
Frog   407 FDQRMKCWQKWQDAQVNLQKKQEAEAKLQISNKPDKLQQAKDEIREEIEEWEAKVQQGERDFDQI 471

  Fly   517 SYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQE 559
            |.|:..|:..|:.||       :::|.:..||:.:.:|...|:
Frog   472 SKTIRKEVGRFEKER-------VRDFKSVIIKYLESLVRTQQQ 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697
		PX_SNX9_18_like	219..343	CDD:132772	33/142 (23%)
		BAR_SNX9_like	362..564	CDD:153310	43/250 (17%)
snx2	XP_012823895.1	Sorting_nexin	2..134	CDD:367612	28/138 (20%)
		PX_SNX2	142..265	CDD:132815	36/160 (23%)
		BAR	283..520	CDD:386243	40/232 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030