DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SH3PX1 and snx33

DIOPT Version :9

Sequence 1:	NP_648348.1	Gene:	SH3PX1 / 39136	FlyBaseID:	FBgn0040475	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001116327.1	Gene:	snx33 / 100001421	ZFINID:	ZDB-GENE-041111-209	Length:	551	Species:	Danio rerio

Alignment Length:	577	Identity:	190/577 - (32%)
Similarity:	314/577 - (54%)	Gaps:	40/577 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSYVRAMYDFTGEPGSSELSIATGDVLSVTRSDVGEGWWEGKNARGQIGLFPAAYVEVMSAAEA 65
            |:...:|:|.|..| ...|::|...:.|.:...:..:||.:|:|:||:.|||||:||.::.:...
Zfish     1 MSLRAKALYTFQSE-NKEEINIQENEELVIFDENSVDGWLQGENSRGERGLFPASYVHIIRSRSG 64

  Fly    66 QKLSASGATSVPQVPDPFASP-------PLPRYDQTADDDGSNWDDEDDWSDDNDTYSEIGPGGQ 123
            ..|:....:|      |.:||       ..|.....:|||    ||.||| |:..|..|
Zfish    65 SNLTDQSFSS------PGSSPGKDLSYIHTPSTTLPSDDD----DDWDDW-DETSTVVE------ 112

  Fly   124 KSAGQSARAGGLSHSTSDYDNK--HLPIAPNDDTQ-SLASVAGGTGAAGTVKK-GMFAKSS-DSY 183
               ....|.|...||.:.|.|.  |....|..|.| |::|...|:.....:.: ..|.:|. :::
Zfish   113 ---DDDHRRGANGHSQNQYSNPNVHYRSKPYMDRQDSMSSNRKGSMVGRNLNRFSSFVRSGVEAF 174

  Fly   184 ILGLSSTKEKIPECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLTPSFN 248
            |||......||.|   :|..::.....||..|..|:|..:..|.|::||||:||:|:|::|||..
Zfish   175 ILGDVPMMAKIAE---SYSIEMGPRGPQWMDNPRPFSCSIEDPTKQTKFKGIKTYISYRVTPSHT 236

  Fly   249 NISVSRRYKHFDWLHERLVDKFCLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFVDWVCRHPVIS 313
            ...|.|||||||||:.||:.||.:|.||.||:||.:||:||.|:|.|:.:|..::|.:..|||:|
Zfish   237 GRPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLS 301

  Fly   314 KCEVWYHFLTCRDEKIWKSGKRKAERDPYMGVNYCLAISPPDKNLLHSKVDAQVELGTQFIHSMD 378
            :.|.:.|||.|.|:|.||.|||:||:|..:|.::.|....|:::.....|:.:::....|...||
Zfish   302 QYEGFEHFLMCGDDKQWKLGKRRAEKDEMVGAHFMLTFQIPNEHQDLQDVEERIDSFKSFAKKMD 366

  Fly   379 VAVRNLNNISNDMAKRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPTRNAVPLSESVGRIGGIF 443
            .:|..|.|:::::.::.:...:|||||:|:|...::::..:|    |..::..||.::...|..:
Zfish   367 DSVMQLTNVASELVRKHLGGFRKEFQRLGNGFQSISQSFLLD----PPYSSDALSNAISHTGRTY 427

  Fly   444 IGIGQAFGDQPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCEKLAGEGRMNNPQLHD 508
            ..||:.|.||||:|...:.|:|.:|:|:|:.||||....|||..|.|:.::::.||:|:..:...
Zfish   428 ENIGEMFADQPKNDLFQMLDKLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGKMDQGEADG 492

  Fly   509 VNRRTDVVSYTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQEASRQIE 565
            :.:|...|.:.:.||:.||...|:...|..::.::.:||.|||.|..:|:...|..:
Zfish   493 IRKRCRTVGFALQAEMNHFHQRREVDFKEMMQAYLRQQIAFYQRVGQQLERTLRMYD 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	20/54 (37%)
		PX_SNX9_18_like	219..343	CDD:132772	63/123 (51%)
		BAR_SNX9_like	362..564	CDD:153310	60/201 (30%)
snx33	NP_001116327.1	SH3_SNX33	4..58	CDD:212829	20/54 (37%)
		PX_domain	207..331	CDD:295365	63/123 (51%)
		BAR_SNX33	342..548	CDD:153353	61/209 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I4139
eggNOG	1	0.900	-	-		E1_KOG2528
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2435
OMA	1	1.010	-	-		QHG48621
OrthoDB	1	1.010	-	-		D351108at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24359
orthoMCL	1	0.900	-	-		OOG6_104281
Panther	1	1.100	-	-	O	PTHR45827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1659
SonicParanoid	1	1.000	-	-		X731
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870