DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16711 and brd4

DIOPT Version :9

Sequence 1:	NP_648347.2	Gene:	CG16711 / 39135	FlyBaseID:	FBgn0036032	Length:	1497	Species:	Drosophila melanogaster
Sequence 2:	NP_001104751.1	Gene:	brd4 / 570531	ZFINID:	ZDB-GENE-030131-267	Length:	1444	Species:	Danio rerio

Alignment Length:	1619	Identity:	311/1619 - (19%)
Similarity:	506/1619 - (31%)	Gaps:	546/1619 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 EEQTTRRRGKGARGKATRAKQKFGHLKVANTPRINKNVLRDIKTEPKCSSEAVVPAAAPAITPIP 133
            |..||..:|:|...:......|.|.:....|.......|.::...|:....   |...|.:.|.|
Zfish   155 EISTTAGKGRGRGRRDPDMNMKVGPVLEPLTASPQTRGLSNLTPGPQTRGP---PQGPPTLPPQP 216

  Fly   134 -----ALNPPIPPQIAA-------LNPPLPEEPT-LAKSLPRTAAVKLETKTHVTSTATASNVAA 185
                 ||.|.:||.:..       |.||....|| .....|...||...|:|          ...
Zfish   217 IVQIQALPPRVPPSLPTIPLHAPQLGPPFSLGPTDCNPPAPIITAVPPPTQT----------ALP 271

  Fly   186 PKRISPKPKAPSVQEKEKEVVSAVTPASLPIPKPAAAPATSPTTPSVNPIFLWVKQDDTRIVEVR 250
            |..|......|.:|          ||.|:|..:.:.......|||:.|
Zfish   272 PVHIQQSAAPPILQ----------TPISIPNKRKSQKRKADTTTPTAN----------------- 309

  Fly   251 CEDYDKRNRIRLTKTTNGWRSMPRTDASSTRIVKFFHGSAAPLMKVKREQHLQRLEEEEQQH--- 312
                |:.|.....::.:| :::||.|.:                   |...|.:.|..:.||
Zfish   310 ----DQLNESSPAESKSG-KTLPRRDNT-------------------RPSKLPKKEAPDSQHHWT 350

  Fly   313 ---------QEQELQQAEDHEREQEQSEQ-----------QMPSIGQTLLQDWDD------SATQ 351
                     |:::|:......::....:.           .:.::|   |.|:.|      ..:.
Zfish   351 AAPGTPSPKQQEQLRYCSGIVKDMFAKKHAAYAWPFYKPVDVDTLG---LHDYHDIIKHPMDLST 412

  Fly   352 LPDEIEEQEEEEEGQESDA--------------AQQQNGHLATVLEDVVVMPPAK---EPE--MA 397
            :.|::|.: :..|.||..|              ...:...:|..|:||..|..||   |||  :|
Zfish   413 IKDKLETR-QYREAQEFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEMLA 476

  Fly   398 PTPCFDGLLDSEETNASTKATKTNTPTYQSSTPSPLQMQLCPKTGLFLPKGDLALVQLPEEDVLP 462
            |.|                     .|...   |:|::.|....|.
Zfish   477 PAP---------------------APVLH---PAPVKTQPVMATA-------------------- 497

  Fly   463 EEAEDKPLGGNDAVECFDANTKNLKDLLDDADDLLQNCSSENGSSGADLLDSLVKRSCEDNLVQE 527
                                         .:.|...:.|||:.||..|..:...:|..|   :||
Zfish   498 -----------------------------SSSDTSSDSSSESESSTDDSEEERAQRLAE---LQE 530

  Fly   528 TRPGNGTNPPNSSASGDGLSSFCVPDLDKDLPRILNMDNDDAPKCLSFNEAGEIEGLNGELFLGI 592
                      ...|..:.|::...|...|  |:....:..:..|.....:||.:..|. |:....
Zfish   531 ----------QLKAVHEQLAALSQPQASK--PKKKEKEKKEKKKDKHKKKAGVMPALE-EILEPP 582

  Fly   593 EAFEKQHEAVATEPEPQ------------------PPTPATVEMTQTPTPTPTPEKEMEK----- 634
            .|.:.|.:....:|.|:                  ||..|      .||..|.|..:.|:
Zfish   583 PALKPQGKPKNKDPLPKKSKKLSKKEGGKSNRSMAPPGAA------PPTLQPVPGLDTEEDLGLT 641

  Fly   635 ------SVVVEETPKDLSYKKREEVCPPSESRSQCAVTSSSDILKSP------------ERELQL 681
                  .:...|..|.:||:::.::              |.||.|.|            .||..|
Zfish   642 GGAAMAGMAAGEKCKPMSYEEKRQL--------------SLDINKLPGDKLGRVVHIIQSREPSL 692

  Fly   682 PANSIPAEVETTSETIKNLILEQF-------LKLNNNPQQAE--------------PMDLGKAGR 725
             .||.|.|:|...||:|...|.:.       |:....|...|              ..|.|.:..
Zfish   693 -KNSNPDEIEIDFETLKPSTLRELERYVSSCLRKKKKPAVPEKSMEAISAVKTKGTSSDSGSSSE 756

  Fly   726 DGKLETVVIDDEEEEDSSQPLKKR-----PKASIKMDKDPDPLTQLKMLISNPQWKVPDPILVPK 785
            ....|:   :|.|...:|:| |||     .||..:......||.|:.:   .||    .|.|.|.
Zfish   757 SSSSES---EDSETGMASKP-KKRGRGEGKKAHHQTTAPGMPLPQVPL---QPQ----TPALQPS 810

  Fly   786 DRLGAVL---ASPAREIPLLLTTRPELRLPEAFAYPEIIQNPNILVVTMEQLEAILKTESEHAAK 847
            .:|....   .|||..:|..:|         |....::::||      .:.|...:  ...|.|.
Zfish   811 IQLKQQQPQHPSPAAYMPPPVT---------ALEPSQLLENP------FDPLAHFM--HLPHHAN 858

  Fly   848 VTKDPDPVIVVPSKARSP-SPK--------QIQPKP-----VPVQPKPPAVAPVAPTPPSPADSS 898
            .:..|.|..:.......| ||:        .|.|.|     :|.||..|: ...||.||.|...|
Zfish   859 DSSSPAPPHLNAHPPGGPVSPETHPFLNQHPILPSPALHNALPQQPSRPS-NRAAPLPPKPLQQS 922

  Fly   899 LSTDLNATTLALLQQMLWLPYFGQLSQEFFKTIKDPLGLQRKFMSNLLPLYNNQFGLQHLDELYK 963
            .|......     ||.|..|...|..|:      .|...|:                |||.....
Zfish   923 TSQQQPPP-----QQTLVPPQQLQPQQQ------QPAPPQQ----------------QHLPHHPL 960

  Fly   964 HCMKQKSTEEQPQPKVTTPVPPPAAAPPPPLPQSTASGPNSFNGFTNPVELALMQKLLQPQLPQF 1028
            |.         ||.....|:.||...|                           |.||..|.||.
Zfish   961 HA---------PQQMRPRPLSPPTLTP---------------------------QGLLSSQPPQM 989

  Fly  1029 LNWEAAKEASSTSSAAATSNHHHHQEHKRPRRDTET-ESISNFTKSKPS-SGAPTTTAA------ 1085
            |..:..:...|.|...       :.:|.:|.|...| .|:....:|:|. .|.|:...:
Zfish   990 LLEDDEEPVPSKSLPM-------YLQHLQPHRLQATPTSLMQSLQSRPQPPGQPSLLQSVQVQSH 1047

  Fly  1086 -PPPAAAAPVPVAT-AAPPAPAPAEHKPRLT---IKSLSNLLEPEANVVPLLNVPFDGMRGRPSM 1145
             |||    .:||.| ..|..|||.:..|:|:   .:.:..|..|:.        |....:.:|..
Zfish  1048 LPPP----QLPVQTQVQPQQPAPHQPSPQLSQHQARHMQQLGFPQG--------PLQTAQTQPGQ 1100

  Fly  1146 HKAVPDQAKGDAGTGRTLRSSKACVTYNPLEQAKQQMHPAAAAQQQRKRGNMLAQDVQQQQHQQN 1210
            ||.             ::.|:||           ||:     .|||        |..|....:|:
Zfish  1101 HKV-------------SMPSTKA-----------QQI-----IQQQ--------QATQHHSPRQH 1128

  Fly  1211 LADAAAAAGMDANSALWHPLFGSNPKQGYNSPWQWTTVTASGEXQSSRAQKEPAPGSGTR----- 1270
            .||:..:|.:..|.:   ||...:|:    .| |::.|..|........|:.|:...|.:
Zfish  1129 KADSYNSAHLRDNPS---PLMMHSPQ----IP-QYSLVHQSPSQDKKEPQRGPSALGGIKEEKLP 1185

  Fly  1271 -----------TASYEEQHQQQD-------YSNYHASAKQQQQQQPQLPAANNQNHSNNSSNKFC 1317
                       .|...|.|:..|       :|...|..|..:..:|.:.::.......:..:|..
Zfish  1186 PSPVMRGEPFSPAMRPESHKHPDSKPTMPGHSQQRADMKPLEMSRPVIRSSEQSGPPPSMQDKEK 1250

  Fly  1318 Y------PTA--AAMENMFQNNQMAAAAAARESLLNSYLYQKDSDAGNYMAEQSYWQQHQQHHHQ 1374
            :      |:|  ...:..|:|....|:.|.:.|...|...:..||:         ::|.::...:
Zfish  1251 FKQEPKTPSAPKKVQDVKFKNMGSWASLAQKSSTTPSSGLKSSSDS---------FEQFRRAARE 1306

  Fly  1375 QQQQQQHQQQQQQQHQQQQHQQQQQ--------------HQQQQHQQQQQQQKQLQQQQQQHQWS 1425
            ::::::..:.|.:|.::.:.:::|:              .:..:..:::|:.:|:|...||||..
Zfish  1307 KEEREKALKAQVEQAEKDRLRKEQEKLRGRDEEDSIEPPRRPLEEPRRRQEPQQVQPPPQQHQTQ 1371

  Fly  1426 ANNGSSNQRSNNYANNYAAAAAASMYMQHFNPYMQQKAALLAEKAAQAAAAAAAVQSSN 1484
            |...:.|...:..|:....|...|..........|::.|...|:..:...|.||....|
Zfish  1372 AQAQTLNPAQSPSASQPTQAPPQSPASSQSALDQQREMARRREQERRRREAMAATIDMN 1430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16711	NP_648347.2	None
brd4	NP_001104751.1	bromodomain 1; BD1	40..152
		Bromo_Brdt_I_like	43..149	CDD:99929
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..217		13/64 (20%)
		bromodomain 2; BD2	356..473		21/120 (18%)
		Bromo_Brdt_II_like	363..464	CDD:99930	16/104 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..523		8/79 (10%)
		NPS region. /evidence=ECO:0000250	498..517		6/18 (33%)
		BID region. /evidence=ECO:0000250	538..610		13/74 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..645		20/113 (18%)
		ET domain	654..729		21/89 (24%)
		BET	657..721	CDD:293640	19/78 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1020..1422		86/467 (18%)
		C-terminal (CTD) region. /evidence=ECO:0000250	1126..1444		57/322 (18%)
		BRD4_CDT	<1419..1444	CDD:293710	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000