DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubc4 and UBE2K

DIOPT Version :9

Sequence 1:	NP_001287013.1	Gene:	Ubc4 / 39133	FlyBaseID:	FBgn0015321	Length:	199	Species:	Drosophila melanogaster
Sequence 2:	NP_005330.1	Gene:	UBE2K / 3093	HGNCID:	4914	Length:	200	Species:	Homo sapiens

Alignment Length:	199	Identity:	136/199 - (68%)
Similarity:	163/199 - (81%)	Gaps:	0/199 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANMAVSRIKREFKEVMRSEEIVQCSIKIELVNDSWTELRGEIAGPPDTPYEGGKFVLEIKVPET 65
            |||:||.|||||||||::|||..:..||::||::::||||||||||||||||||::.||||:|||
Human     1 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPET 65

  Fly    66 YPFNPPKVRFITRIWHPNISSVTGAICLDILKDNWAAAMTLRTVLLSLQALLAAAEPDDPQDAVV 130
            ||||||||||||:||||||||||||||||||||.|||||||||||||||||||||||||||||||
Human    66 YPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVV 130

  Fly   131 AYQFKDKYDLFLLTAKHWTNAYAGGPHTFPDCDSKIQRLRDMGIDEHEARAVLSKENWNLEKATE 195
            |.|:|...::|..||:.|.:.|||.|.:.|:...||:.|..||.|.:.....||.::|::|.|||
Human   131 ANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETATE 195

  Fly   196 GLFS 199
            .|.|
Human   196 LLLS 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubc4	NP_001287013.1	COG5078	1..153	CDD:227410	116/151 (77%)
		UQ_con	8..149	CDD:278603	110/140 (79%)
		UBA_II_E2_UBCD4	163..198	CDD:270574	13/34 (38%)
UBE2K	NP_005330.1	UBCc	6..149	CDD:238117	111/142 (78%)
UBE2K	NP_005330.1	UBA_II_E2_UBE2K	163..200	CDD:270573	15/37 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160465
Domainoid	1	1.000	228	1.000	Domainoid score	I2501
eggNOG	1	0.900	-	-		E2759_KOG0418
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3903
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2925
Isobase	1	0.950	-	0	Normalized mean entropy	S653
OMA	1	1.010	-	-		QHG57104
OrthoDB	1	1.010	-	-		D1418652at2759
OrthoFinder	1	1.000	-	-		FOG0003491
OrthoInspector	1	1.000	-	-		oto90641
orthoMCL	1	0.900	-	-		OOG6_103192
Panther	1	1.100	-	-	LDO	PTHR24068
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4349
SonicParanoid	1	1.000	-	-		X2383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750