Protein Alignment Prps and PRPSAP1

DIOPT Version :10

• Sequence 1: NP_729528.2
• Gene: Prps / 39132
• FlyBaseID: FBgn0036030
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_002757.2
• Gene: PRPSAP1 / 5635
• HGNCID: 9466
• Length: 385
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 156/370 - (42%)
• Similarity: 213/370 - (57%)
• Gaps: 61/370 - (16%)

  Fly    52 KVFSGTSH---PDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDN 113
            :|||..|.   .:||:||.:|||.:|||.|..:.:|.||.|||.|||||:|::|:|:...::|..
Human    38 RVFSANSTAACTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTA 102

  Fly   114 LMELLIMINACKIASASRVTAVIPCFPYARQDKKDKLAGSEDNAESKKLAKKNYDWKFRSRAPIS 178
            :||||||..|.|.|.|..:..|||.|||::|.                        |.|.|..|.
Human   103 VMELLIMAYALKTACARNIIGVIPYFPYSKQS------------------------KMRKRGSIV 143

  Fly   179 AKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIPEWKNSIIV--SPD 241
            .||:|:||:.||..||||||||..:|||||..|||||.|.|.:|::|:|.||.::|::||  |||
Human   144 CKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVAKSPD 208

  Fly   242 AGGAKRVTSIADRLNVEFALIHKERK------------------------------KANEVASMV 276
            |  |||..|.|:||.:..|:||.|.:                              .|.|...:.
Human   209 A--AKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPIT 271

  Fly   277 LVGDVKDKIAILVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVV 341
            :||||..:|||:|||:.|...:.|.||:.|.|.||.|:|.:.||||.|..|...|..:..:.|||
Human   272 VVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVV 336

  Fly   342 TNTIPQDGHMRDCPKIQCIDVSMMFAEAVRRTHNGESVSYLFSNV 386
            |||:|.:.....||||:.:|:|::.:||:||.|||||::|||.|:
Human   337 TNTVPHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFRNI 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prps	NP_729528.2	PrsA	48..384	CDD:440230	154/366 (42%)
PRPSAP1	NP_002757.2	Pribosyltran_N	38..155	CDD:433483	56/140 (40%)
		Pribosyl_synth	196..379	CDD:434046	71/184 (39%)