Protein Alignment Prps and PRPSAP1

DIOPT Version :9

• Sequence 1: NP_729528.2
• Gene: Prps / 39132
• FlyBaseID: FBgn0036030
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_002757.2
• Gene: PRPSAP1 / 5635
• HGNCID: 9466
• Length: 385
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 156/370 - (42%)
• Similarity: 213/370 - (57%)
• Gaps: 61/370 - (16%)

  Fly    52 KVFSGTSH---PDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDN 113
            :|||..|.   .:||:||.:|||.:|||.|..:.:|.||.|||.|||||:|::|:|:...::|..
Human    38 RVFSANSTAACTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTA 102

  Fly   114 LMELLIMINACKIASASRVTAVIPCFPYARQDKKDKLAGSEDNAESKKLAKKNYDWKFRSRAPIS 178
            :||||||..|.|.|.|..:..|||.|||::|.                        |.|.|..|.
Human   103 VMELLIMAYALKTACARNIIGVIPYFPYSKQS------------------------KMRKRGSIV 143

  Fly   179 AKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIPEWKNSIIV--SPD 241
            .||:|:||:.||..||||||||..:|||||..|||||.|.|.:|::|:|.||.::|::||  |||
Human   144 CKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVAKSPD 208

  Fly   242 AGGAKRVTSIADRLNVEFALIHKERK------------------------------KANEVASMV 276
            |  |||..|.|:||.:..|:||.|.:                              .|.|...:.
Human   209 A--AKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPIT 271

  Fly   277 LVGDVKDKIAILVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVV 341
            :||||..:|||:|||:.|...:.|.||:.|.|.||.|:|.:.||||.|..|...|..:..:.|||
Human   272 VVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVV 336

  Fly   342 TNTIPQDGHMRDCPKIQCIDVSMMFAEAVRRTHNGESVSYLFSNV 386
            |||:|.:.....||||:.:|:|::.:||:||.|||||::|||.|:
Human   337 TNTVPHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFRNI 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prps	NP_729528.2	PrsA	48..383	CDD:223538	153/365 (42%)
PRPSAP1	NP_002757.2	PrsA	37..379	CDD:223538	154/366 (42%)
		Pribosyltran_N	38..155	CDD:290508	56/140 (40%)
		Pribosyl_synth	196..379	CDD:291252	71/184 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60704
OrthoDB	1	1.010	-	-		D1043963at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830