Protein Alignment Prps and PRPS1L1

DIOPT Version :10

• Sequence 1: NP_729528.2
• Gene: Prps / 39132
• FlyBaseID: FBgn0036030
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_787082.1
• Gene: PRPS1L1 / 221823
• HGNCID: 9463
• Length: 318
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 272/340 - (80%)
• Similarity: 296/340 - (87%)
• Gaps: 23/340 - (6%)

  Fly    48 MPNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEIND 112
            |||||:|||:||.||:|:|.||||::|||||||||||.||||||.||||||||||||||.|||||
Human     1 MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQSGCGEIND 65

  Fly   113 NLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKLAGSEDNAESKKLAKKNYDWKFRSRAPI 177
            :||||||||||||||||||||||||||||||||||||                       ||:||
Human    66 SLMELLIMINACKIASASRVTAVIPCFPYARQDKKDK-----------------------SRSPI 107

  Fly   178 SAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIPEWKNSIIVSPDA 242
            ||||||||||:|||||||||||||||||||||||||||||||.|||||:||||||||.|||||||
Human   108 SAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDA 172

  Fly   243 GGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAILVDDMADTCGTIVHAADRLV 307
            |||||||||||:|||:||||||||||||||..:||||||.|::|||||||||||.||..|||:|:
Human   173 GGAKRVTSIADQLNVDFALIHKERKKANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLL 237

  Fly   308 EAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDCPKIQCIDVSMMFAEAVRR 372
            .||||:|||||||||||||||||||.|||||||||||||||..|:.|.||:.||:||:.|||:||
Human   238 SAGATRVYAILTHGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILAEAIRR 302

  Fly   373 THNGESVSYLFSNVP 387
            ||||||||||||:||
Human   303 THNGESVSYLFSHVP 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prps	NP_729528.2	PrsA	48..384	CDD:440230	268/335 (80%)
PRPS1L1	NP_787082.1	PrsA	1..314	CDD:440230	268/335 (80%)
		Binding of phosphoribosylpyrophosphate. /evidence=ECO:0000255	212..227		11/14 (79%)