DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaTub67C and tuba8l5

DIOPT Version :9

Sequence 1:	NP_524009.2	Gene:	alphaTub67C / 39130	FlyBaseID:	FBgn0087040	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001161759.1	Gene:	tuba8l5 / 792024	ZFINID:	ZDB-GENE-100921-8	Length:	477	Species:	Danio rerio

Alignment Length:	461	Identity:	317/461 - (68%)
Similarity:	380/461 - (82%)	Gaps:	13/461 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 REVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFTE 66
            ||.:|:.:||.|.||||||||||.|||||..||.:.:...:.        |.|.|.|   |||:|
Zfish    30 RECISVHVGQAGAQIGNACWELYCLEHGIQPDGQMPSDRSIG--------GGDDSFN---TFFSE 83

  Fly    67 TGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVTS 131
            |.:||.|||:|||||||||||:||.|..|:|:||||||:||||||||||||.|:||||:||.|..
Zfish    84 TASGKHVPRAIFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDSVLD 148

  Fly   132 RLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEPY 196
            |::|:::||..|||||:|||.||||||||||||:||||.||.||.||:||:||:|:|||||||||
Zfish   149 RIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPY 213

  Fly   197 NALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMNV 261
            |::||||:|::||||.||||||||||||..:|.::||.|.||||||.|||||.||||||.|::||
Zfish   214 NSILTTHTTLEHSDCAFMVDNEAIYDICRKNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNV 278

  Fly   262 DLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITTLTNACFESSNMMVKCDPRAGKFMAC 326
            ||.||||||||:|||||||..|||::|||::.|||.::..:||||||.||.|||||||.||:|||
Zfish   279 DLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVADITNACFEPSNQMVKCDPRHGKYMAC 343

  Fly   327 CMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCMLSN 391
            |:||||||||||||:|::|||:||.||||||||||||:||||:.|..||.|||||..||.|||||
Zfish   344 CLLYRGDVVPKDVNSAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSN 408

  Fly   392 TTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDFEEVGLDNAEEGGD 456
            ||||:.|::.|.:|||||:.||||||||||||||||||:||||::|.||:|:||||.|:.  |.|
Zfish   409 TTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSI--GDD 471

  Fly   457 EDFDEF 462
            ||..||
Zfish   472 EDGVEF 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	307/443 (69%)
tuba8l5	NP_001161759.1	PTZ00335	30..474	CDD:185562	314/456 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275336at33208
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100108
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720