DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub67C and Tubb1

DIOPT Version :9

Sequence 1:	NP_524009.2	Gene:	alphaTub67C / 39130	FlyBaseID:	FBgn0087040	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	XP_003749686.1	Gene:	Tubb1 / 679312	RGDID:	1589557	Length:	452	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	181/463 - (39%)
Similarity:	271/463 - (58%)	Gaps:	26/463 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFT 65
            |||:|.|||||||.|||...||:...||||:..||.        .|:||     ........::.
  Rat     1 MREIVHIQIGQCGNQIGAKFWEVIGEEHGIDCAGSY--------CGTSA-----LQLERISVYYN 52

  Fly    66 ETGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVT 130
            |....|.|||::.|||||..:|.:|:..:..|:.|:..:.|...|.||:|:|.|:.|.|:|:.|.
  Rat    53 EAYGKKYVPRAVLVDLEPGTMDSIRSSRLGILFQPDSFVHGNSGAGNNWAKGHYTEGAELIETVM 117

  Fly   131 SRLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEP 195
            ..:::.:|.||.||||.|.||||||||||..:||:.::..:|..:....|:|.||||||..||||
  Rat   118 DVVRRESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRILNSFSVMPSPKVSDTVVEP 182

  Fly   196 YNALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMN 260
            |||:|:.|..::::|..|.:||||:||||..:|.:..|.|.:||.|::..:|..|.||||.|.:|
  Rat   183 YNAVLSIHQLIENTDACFCIDNEALYDICFRTLRLTTPTYGDLNHLVSLTMSGITTSLRFPGQLN 247

  Fly   261 VDLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITTLTNACFESSNMMVKCDPRAGKFMA 325
            .||.:...|:|||||:||.:..:|||.:.....:...::..||...|::.|:|..||||.|:::.
  Rat   248 ADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNIMAACDPRRGRYLT 312

  Fly   326 CCMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCMLS 390
            ...::||.:..|:|:..:.:|:::....||:|.|...|:.:     ..:|...|   :.|...|.
  Rat   313 VACIFRGKMSTKEVDQQLLSIQTRNSNCFVEWIPNNVKVAV-----CDIPPRGL---NMAATFLG 369

  Fly   391 NTTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDFEE-----VGLDN 450
            |.|||...|:.:|..|..||::|||||||..|||:..||.||..:|..|..::::     .||::
  Rat   370 NNTAIQELFTRVSEHFSAMFRRRAFVHWYTSEGMDISEFGEAEADILDLVSEYQQFQDVRAGLED 434

  Fly   451 AEEGGDED 458
            .||||:|:
  Rat   435 IEEGGEEE 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	173/448 (39%)
Tubb1	XP_003749686.1	PTZ00010	1..428	CDD:240228	174/447 (39%)
Tubb1	XP_003749686.1	beta_tubulin	2..426	CDD:276956	173/444 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900