DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub67C and Tuba3a

DIOPT Version :9

Sequence 1:	NP_524009.2	Gene:	alphaTub67C / 39130	FlyBaseID:	FBgn0087040	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001035097.1	Gene:	Tuba3a / 500319	RGDID:	1565719	Length:	450	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	315/460 - (68%)
Similarity:	380/460 - (82%)	Gaps:	14/460 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFT 65
            |||.:||.:||.|:||||||||||.|||||..||.:.:.:.:.        |.|.|.|   |||:
  Rat     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIG--------GGDDSFN---TFFS 54

  Fly    66 ETGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVT 130
            |||.||.|||::||||||||:|:||.|..|:|:||||||:||||||||||||.|:||||::|.|.
  Rat    55 ETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVL 119

  Fly   131 SRLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEP 195
            .|::|:|:.|..|||||||||.||||||||.|||:||||.||.||.||:||:||:|:||||||||
  Rat   120 DRIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEP 184

  Fly   196 YNALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMN 260
            ||::||||:|::||||.||||||||||||..:|.::||.|.||||||.|||||.||||||.|::|
  Rat   185 YNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALN 249

  Fly   261 VDLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITTLTNACFESSNMMVKCDPRAGKFMA 325
            |||.||||||||:|||||||..|||::|||::.|||.::..:||||||.:|.|||||||.||:||
  Rat   250 VDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMA 314

  Fly   326 CCMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCMLS 390
            |||||||||||||||||::.||:||.||||||||||||:||||:.|..||.|||||..||.||||
  Rat   315 CCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLS 379

  Fly   391 NTTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDFEEVGLDNAE--- 452
            |||||:.|::.|.:|||||:.||||||||||||||||||:||||::|.||:|:||||:|:.|
  Rat   380 NTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEAEA 444

  Fly   453 EGGDE 457
            |.|:|
  Rat   445 EEGEE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	306/443 (69%)
Tuba3a	NP_001035097.1	PTZ00335	1..440	CDD:185562	311/449 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275336at33208
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100108
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720