DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub67C and tuba8l2

DIOPT Version :9

Sequence 1:	NP_524009.2	Gene:	alphaTub67C / 39130	FlyBaseID:	FBgn0087040	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_956985.1	Gene:	tuba8l2 / 393664	ZFINID:	ZDB-GENE-040426-1646	Length:	449	Species:	Danio rerio

Alignment Length:	462	Identity:	317/462 - (68%)
Similarity:	386/462 - (83%)	Gaps:	13/462 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFT 65
            |||.:|:.:||.|:|:||.|||||.|||||..||.:.:.:.:.        |||.|..   |||:
Zfish     1 MRECISVHVGQAGVQMGNTCWELYCLEHGIQPDGQMPSHKPVG--------GHDDSFT---TFFS 54

  Fly    66 ETGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVT 130
            |||.||.|||:|||||||||||:||.|..|:|:|||||||||||||||||||.|:||||:||.|.
Zfish    55 ETGAGKYVPRAIFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIIDSVL 119

  Fly   131 SRLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEP 195
            .|::|:|:||..|||||:|||.||||||||||||:||||.|:.||.||:||:||:|:||||||||
Zfish   120 DRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDFGKKSKLEFAIYPAPQVSTAVVEP 184

  Fly   196 YNALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMN 260
            ||::||||:|::||||.||||||||||||..:|.::||:|.||||||:|||||.||||||.|::|
Zfish   185 YNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPSYTNLNRLISQIVSSITASLRFDGALN 249

  Fly   261 VDLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITTLTNACFESSNMMVKCDPRAGKFMA 325
            |||.||||||||:|||||||..|||::|||::.|||.::..:||:|||.||.|||||||.||:||
Zfish   250 VDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNSCFEPSNQMVKCDPRHGKYMA 314

  Fly   326 CCMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCMLS 390
            ||:||||||||||||.|::|||:||.||||||||||||:||||:.|..||.|||||..||.||||
Zfish   315 CCLLYRGDVVPKDVNVAIAAIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLS 379

  Fly   391 NTTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDFEEVGLDNAEEGG 455
            |||||:.|::.|.:|||||:.||||||||||||||||||:||||::|.||:|:||||:|:.||
Zfish   380 NTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGIDSFEE-- 442

  Fly   456 DEDFDEF 462
            ||:.:||
Zfish   443 DEEGEEF 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	306/443 (69%)
tuba8l2	NP_956985.1	PTZ00335	1..439	CDD:185562	310/448 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275336at33208
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100108
Panther	1	1.100	-	-	O	PTHR11588
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820