DRSC/TRiP Functional Genomics Resources

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Protein Alignment alphaTub67C and TUBB2B

DIOPT Version :9

Sequence 1:NP_524009.2 Gene:alphaTub67C / 39130 FlyBaseID:FBgn0087040 Length:462 Species:Drosophila melanogaster
Sequence 2:NP_821080.1 Gene:TUBB2B / 347733 HGNCID:30829 Length:445 Species:Homo sapiens


Alignment Length:467 Identity:185/467 - (39%)
Similarity:268/467 - (57%) Gaps:33/467 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MREVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFT 65
            |||:|.||.||||.|||...||:...||||:..||.        .|.|     |........::.
Human     1 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSY--------HGDS-----DLQLERINVYYN 52

  Fly    66 ETGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVT 130
            |....|.|||:|.|||||..:|.||:|...:::.|:..:.|:..|.||:|:|.|:.|.|::|.|.
Human    53 EATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVL 117

  Fly   131 SRLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEP 195
            ..::|.:|.||.||||.:.||||||||||..:||:.::..:|..:....|:|.||||||..||||
Human   118 DVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEP 182

  Fly   196 YNALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMN 260
            |||.|:.|..::::|..:.:||||:||||..:|.:..|.|.:||.|::..:|..|..|||.|.:|
Human   183 YNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLN 247

  Fly   261 VDLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITT--LTNACFESSNMMVKCDPRAGKF 323
            .||.:...|:|||||:||.:..:|||.|  |.:.:..|:|.  ||...|:|.|||..||||.|::
Human   248 ADLRKLAVNMVPFPRLHFFMPGFAPLTS--RGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRY 310

  Fly   324 MACCMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCM 388
            :....::||.:..|:|:..:..:::|....||:|.|...|..:     ..:|...|   ..:...
Human   311 LTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAV-----CDIPPRGL---KMSATF 367

  Fly   389 LSNTTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDF--------EE 445
            :.|:|||...|..:|.:|..||:::||:|||.||||:|.|||||..|:..|..::        :|
Human   368 IGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADE 432

  Fly   446 VGLDNAEEGGDE 457
            .|....|||.||
Human   433 QGEFEEEEGEDE 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alphaTub67CNP_524009.2 alpha_tubulin 2..446 CDD:276955 177/453 (39%)
TUBB2BNP_821080.1 PLN00220 1..430 CDD:215107 178/451 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..445 7/23 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5023
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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