DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub67C and tuba4l

DIOPT Version :9

Sequence 1:	NP_524009.2	Gene:	alphaTub67C / 39130	FlyBaseID:	FBgn0087040	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_956089.1	Gene:	tuba4l / 327377	ZFINID:	ZDB-GENE-030131-5588	Length:	449	Species:	Danio rerio

Alignment Length:	462	Identity:	316/462 - (68%)
Similarity:	385/462 - (83%)	Gaps:	13/462 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFT 65
            |||.:||.|||.|||:||:|||||.||||...||        |...||.|:. |:|..   |||:
Zfish     1 MRECISIHIGQAGIQMGNSCWELYCLEHGFQPDG--------TIVDSSRSLA-DSSFG---TFFS 53

  Fly    66 ETGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVT 130
            |||.||.|||::|:||||||:|::|||..|:|||||||||||||||||||||.|:||||::|.|.
Zfish    54 ETGAGKYVPRAVFIDLEPTVVDEIRNGHYRQLYHPEQLISGKEDAANNYARGHYTIGKEIVDSVL 118

  Fly   131 SRLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEP 195
            .|::|:|:||..|||||||||.||||||||||||:||||.||.||.||:|:|||:|:||||||||
Zfish   119 DRMRKMADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSVYPAPQVSTAVVEP 183

  Fly   196 YNALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMN 260
            ||::||||:|::||||.||||||||:|||..:|.::||:|.||||||||||||.||||||.|::|
Zfish   184 YNSILTTHTTLEHSDCSFMVDNEAIFDICKRNLDIERPSYTNLNRLIAQIVSSITASLRFDGALN 248

  Fly   261 VDLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITTLTNACFESSNMMVKCDPRAGKFMA 325
            |||.||||||||:||||||||.|:|::|||::.|||.::..:||||||.:|.|||||||.||:||
Zfish   249 VDLTEFQTNLVPYPRIHFPLVTYSPIISAEKAYHEQLSVPEITNACFEPANQMVKCDPRRGKYMA 313

  Fly   326 CCMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCMLS 390
            ||:||||||||||||||::.||::|.||||||||||||:||||:.|..||.|||||..||.||||
Zfish   314 CCLLYRGDVVPKDVNAAIANIKTRRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLS 378

  Fly   391 NTTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDFEEVGLDNAEEGG 455
            |||||:.|:..|.:|||||:.||||||||||||||||||:||||::|.||:|:|||..|:.::.|
Zfish   379 NTTAIAEAWGRLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVAADSTDDCG 443

  Fly   456 DEDFDEF 462
             ||.:|:
Zfish   444 -EDEEEY 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	308/443 (70%)
tuba4l	NP_956089.1	PTZ00335	1..449	CDD:185562	315/460 (68%)
tuba4l	NP_956089.1	alpha_tubulin	2..434	CDD:276955	308/443 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275336at33208
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100108
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.770