DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub67C and mec-12

DIOPT Version :9

Sequence 1:	NP_524009.2	Gene:	alphaTub67C / 39130	FlyBaseID:	FBgn0087040	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_497663.1	Gene:	mec-12 / 175419	WormBaseID:	WBGene00003175	Length:	450	Species:	Caenorhabditis elegans

Alignment Length:	462	Identity:	308/462 - (66%)
Similarity:	380/462 - (82%)	Gaps:	12/462 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFT 65
            ||||:||.|||.|:||||||||||.|||||..||.:.:.:.|..|..|.|           |||:
Worm     1 MREVISIHIGQAGVQIGNACWELYCLEHGIQPDGQMPSDKSLGGSDDSFS-----------TFFS 54

  Fly    66 ETGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVT 130
            |||:|:.|||::.|||||||||::|.|..|.|:||||||:||||||||||||.|:||||:||...
Worm    55 ETGSGRHVPRAVMVDLEPTVIDEIRTGTYRSLFHPEQLITGKEDAANNYARGHYTIGKEIIDLTL 119

  Fly   131 SRLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEP 195
            .|::::|:.|..|||||:|||.||||||||||||:||||.||.||.||:|::||:|:||||||||
Worm   120 DRIRRLADNCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKAKLEFSIYPAPQVSTAVVEP 184

  Fly   196 YNALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMN 260
            ||::||||:|::||||.||||||||||||..:|.::||:|.||||||.|||||.||||||.|::|
Worm   185 YNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLDIERPSYTNLNRLIGQIVSSITASLRFDGALN 249

  Fly   261 VDLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITTLTNACFESSNMMVKCDPRAGKFMA 325
            |||.||||||||:|||||||..::|::|||::.|||.::..:||.|||..|.|||||||.||:||
Worm   250 VDLTEFQTNLVPYPRIHFPLATFSPVISAEKAYHEQLSVAEITNMCFEPHNQMVKCDPRHGKYMA 314

  Fly   326 CCMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCMLS 390
            .|:|:||||||||||||::.||:||.||||||||||||:||||:.|..||.|||||..||.||||
Worm   315 VCLLFRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVPRAVCMLS 379

  Fly   391 NTTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDFEEVGLDNAEEGG 455
            |||||:.|::.|.:|||||:.||||||||||||||||||:||||::|.||:|:||||:|:.|:.|
Worm   380 NTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSMEDNG 444

  Fly   456 DEDFDEF 462
            :|. ||:
Worm   445 EEG-DEY 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	298/443 (67%)
mec-12	NP_497663.1	PTZ00335	1..448	CDD:185562	306/458 (67%)
mec-12	NP_497663.1	alpha_tubulin	2..435	CDD:276955	298/443 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S25
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275336at33208
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100108
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.670