DRSC/TRiP Functional Genomics Resources

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Protein Alignment LAMB2 and VPS36

DIOPT Version :9

Sequence 1:NP_002283.3 Gene:LAMB2 / 3913 HGNCID:6487 Length:1798 Species:Homo sapiens
Sequence 2:NP_013521.3 Gene:VPS36 / 851135 SGDID:S000004409 Length:566 Species:Saccharomyces cerevisiae


Alignment Length:338 Identity:68/338 - (20%)
Similarity:107/338 - (31%) Gaps:128/338 - (37%)


- Green bases have known domain annotations that are detailed below.


Human  1150 IDTPQCHRFTGHCSCRPGV--------SGVRC-----------DQCARGFSGIFPAC----HP-- 1189
            :.||.|      .:|  ||        |.:.|           :|.......|.|||    ||  
Yeast   138 LPTPIC------INC--GVPADYELTKSSINCSNAIDPNANPQNQFGVNSENICPACTFANHPQI 194

Human  1190 --CHACFGDWDRVVQDLAARTQRLEQRAQELQQTGVLGAFESSFWHMQ-EKLGIVQGIVGARN-- 1249
              |..|              ..||...::...:...|. |..|..|:: ||..:      |||  
Yeast   195 GNCEIC--------------GHRLPNASKVRSKLNRLN-FHDSRVHIELEKNSL------ARNKS 238

Human  1250 -----TSAASTAQLVEATE-ELRREIG----EATEHLTQLEADLTDVQDENFNAN---------- 1294
                 :|::||....|..: ..|:..|    :|||.  .||..||:.....||.|          
Yeast   239 SHSALSSSSSTGSSTEFVQLSFRKSDGVLFSQATER--ALENILTEKNKHIFNQNVVSVNGVDMR 301

Human  1295 -----H----------------ALSGLERDR--------LALNLTLRQLDQHLDLLKHSNFLGAY 1330
                 |                .:|.||:.|        :..|..|..|::.:.|.         
Yeast   302 KGASSHEYNNEVPFIETKLSRIGISSLEKSRENQLLNNDILFNNALTDLNKLMSLA--------- 357

Human  1331 DSIRHAHSQSAEAERRANTSALAVPSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSA 1395
            .||...:..| ....:..|..|...|.|:...:.|    .|:...:|.|.:|.:    .|.:::.
Yeast   358 TSIERLYKNS-NITMKTKTLNLQDESTVNEPKTRR----PLLILDREKFLNKEL----FLDEIAR 413

Human  1396 HTHTLSLTDINEL 1408
            ..:..:|::..:|
Yeast   414 EIYEFTLSEFKDL 426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMB2NP_002283.3 Laminin_N 57..281 CDD:278484
EGF_Lam 283..335 CDD:238012
EGF_Lam 347..399 CDD:238012
Laminin_EGF 410..467 CDD:278482
EGF_Lam 469..520 CDD:238012
EGF_Lam 521..562 CDD:238012
Laminin_EGF 783..831 CDD:278482
Laminin_EGF 831..879 CDD:278482
EGF_Lam 876..921 CDD:238012
EGF_Lam 926..984 CDD:238012
Laminin_EGF 986..>1028 CDD:278482
EGF_Lam 1037..1093 CDD:238012
Laminin_EGF 1095..1143 CDD:278482
Laminin_EGF 1143..>1182 CDD:278482 9/50 (18%)
Domain II 1190..1409 53/271 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1338..1364 5/25 (20%)
Domain alpha 1410..1442
Domain I 1443..1798
MA 1445..1701 CDD:214599
ATP-synt_B <1453..1541 CDD:304375
HrpJ 1483..1670 CDD:301626
V-ATPase_G_2 1648..1755 CDD:293604
ATP-synt_B <1680..1792 CDD:304375
VPS36NP_013521.3 PH-GRAM-like_Vps36 4..122 CDD:275409
Vps36-NZF-N 109..164 CDD:407195 8/33 (24%)
RanBP2-type Zn finger 118..146 CDD:275376 3/13 (23%)
ZnF_RBZ 179..203 CDD:197784 8/37 (22%)
RanBP2-type Zn finger 181..200 CDD:275376 7/18 (39%)
EAP30 323..549 CDD:398021 23/122 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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