DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LAMB2 and lamb2

DIOPT Version :9

Sequence 1:	NP_002283.3	Gene:	LAMB2 / 3913	HGNCID:	6487	Length:	1798	Species:	Homo sapiens
Sequence 2:	XP_005162102.1	Gene:	lamb2 / 337767	ZFINID:	ZDB-GENE-081030-4	Length:	1794	Species:	Danio rerio

Alignment Length:	1797	Identity:	1068/1797 - (59%)
Similarity:	1337/1797 - (74%)	Gaps:	19/1797 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    18 LRLGLLLSVLAATLAQAPAPDVP-GCSRGSCYPATGDLLVGRADRLTASSTCGLNGPQPYCIVSH 81
            :|..||||:...:...|..||.. ||:.||||||||||||||...|.|||||||...:|||||||
Zfish     1 MRALLLLSICVLSAVSAQEPDAAHGCTHGSCYPATGDLLVGREANLKASSTCGLRRREPYCIVSH 65

Human    82 LQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRRAAWWQSENGIPAVTIQLDLEAEFHFT 146
            ||:|||||.||||||:..:.||.||||:||:|:|.|.|:.:|||||||...|.:|||||||||||
Zfish    66 LQEEKKCFQCDSRRPYDPQSNPVSHRIENVITTFKPHRKKSWWQSENGKSDVYLQLDLEAEFHFT 130

Human   147 HLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCGADFPGVPLAPPRHWDDVVCESRYSEIEP 211
            |||||||||||||||:||||||||:|.|||||:.||.:.|||:.....|..|||:||||||:|||
Zfish   131 HLIMTFKTFRPAAMLIERSADFGRSWQVYRYFANDCESIFPGISQDSLRKVDDVICESRYSDIEP 195

Human   212 STEGEVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYE 276
            |||||||:|||||||.|.||||.||||.|||||||:|||:||||||||||.|.||:||||||:||
Zfish   196 STEGEVIFRVLDPAIRIEDPYSPRIQNQLKITNLRLNLTKLHTLGDNLLDSRPEIKEKYYYAMYE 260

Human   277 LVVRGNCFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHS 341
            ||||||||||||||||||..|.....||||||.|:|||||:|||||||.|||.||||||||..::
Zfish   261 LVVRGNCFCYGHASECAPIEGIRDDIEGMVHGRCVCKHNTKGLNCEQCDDFYNDLPWRPAEGRNT 325

Human   342 HACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAV 406
            :||:||.|:||::.||||||||||:||:||||||.|.|||.|.:||.|:||:|:|||:|:|||.|
Zfish   326 NACKKCNCNGHSNQCHFDMAVYLATGNISGGVCDNCLHNTMGSNCESCKPFYYQDPTRDIRDPGV 390

Human   407 CRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQ 471
            |.:|||||.||::||.||.||||:||:::||||||::|.|:||.:|:.||||||.||..||:.|:
Zfish   391 CVACDCDPDGSKNGGVCDGHDDPSLGMIAGQCRCKDNVEGSRCDKCKPGFFGLSASDPRGCQPCK 455

Human   472 CNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDE 536
            |:.||||.||:.|||.||.|:|||||||..|::|||.||.||||..|||.||||||||.:.||..
Zfish   456 CDPRGTVSGSSQCDPVSGDCFCKRLVTGHSCNQCLPEHWALSHDTSGCRGCDCDVGGATENQCSM 520

Human   537 GTGQCHCRQHMVGRRCEQVQPGYFRPFLDHLIWEAEDTR---GQVLDVVERLVTPGETPSWTGSG 598
            .||||.||.||:||:|.||:.|||...|||.|:|||..:   |.|.:  ||...||...||||:|
Zfish   521 ETGQCQCRSHMIGRQCNQVESGYFFMALDHYIYEAETAKLGQGSVFE--EREYQPGRPISWTGTG 583

Human   599 FVRLQEGQTLEFLVASVPKAMDYDLLLRLEPQVPEQWAELELIVQRPGPVPAHSLCGHLVPKDDR 663
            |.|..||.||||.:.::|.:|:||:|:|.|.|:|..|.|:.::|.||||:|..|.||:.:|.||.
Zfish   584 FARAPEGGTLEFAINNIPYSMEYDVLIRYELQMPRDWEEVRVVVIRPGPIPTSSPCGNTIPADDL 648

Human   664 IQGTLQPHARYLIFPNPVCLEPGISYKLHLKLVRTGGSAQPETPYSGPGLLIDSLVLLPRVLVLE 728
            :..:|...||:::.|.|||||.|:||||.::|:|........|. :...:|:||:.||||.|.||
Zfish   649 LTVSLSSGARFVVLPQPVCLESGVSYKLRVELIRYADRNSIITS-TNAFVLVDSIALLPRYLSLE 712

Human   729 MFSGGDAAALERQATFERYQCHEEGLVPSKTSPSEACAPLLISLSTLIYNGALPCQCNPQGSLSS 793
            ||:.||.|::.|:.:||||:|||.....|:...||.||.|:.|:|.||.:|||.|:|:|||||||
Zfish   713 MFTAGDPASVARKQSFERYRCHETAKSVSRPQMSEVCAKLITSMSALINDGALACECDPQGSLSS 777

Human   794 ECNPHGGQCLCKPGVVGRRCDLCAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTGAFG 858
            ||:..||||.|:|.:.||||:.||||.|||||:||:.|:||.||:.|..|:..||||.||.||:|
Zfish   778 ECDVRGGQCRCRPNISGRRCEKCAPGAYGFGPSGCKLCECSLEGSQSRFCDLYSGQCPCRPGAYG 842

Human   859 LRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQ 923
            .|||.||.|.||||:||||.||||||||:..|||||.||.:|.|:.||||..|::|:|.|..|.|
Zfish   843 QRCDGCQAGHWGFPNCRPCQCNGHADECHQRTGACLNCRSNTAGDKCERCANGYYGNPVLGLGSQ 907

Human   924 CRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGL------------RCEACAPGHFGDP 976
            ||||||||||.|.||||.||:||..|||:||:|..||||.            ||:.||||:||||
Zfish   908 CRPCPCPEGPNSGRHFAASCYQDNRSQQVVCNCNQGYTGTVKRSAGAVLNRPRCDECAPGYFGDP 972

Human   977 SRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHRCTCN 1041
            |:|||:||.|.||.|||..||::||..|||||:||::||||.|:.|:.|::|.|:|::|.:||||
Zfish   973 SKPGGQCQPCRCSNNIDLSDPESCDKRTGQCLKCLYNTEGPDCSVCRSGYYGDASRRNCRKCTCN 1037

Human  1042 LLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPT 1106
            .|||...||.|.|.|.|..::|||.|||||.|.:||.||||.|||.||.||:||||.|:.|....
Zfish  1038 FLGTERSQCLSRDDCVCQRATGQCQCLPNVIGQTCDHCAPNSWNLASGQGCEPCACDPNNAYTSA 1102

Human  1107 CNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVSGV 1171
            ||||||||.||.||||:||::|||.|||||.:.|.|||||.|||::.||:|.||||.|:.|||||
Zfish  1103 CNEFTGQCQCRVGFGGKTCTDCQENHWGDPRVLCRACDCDPRGIESSQCNRMTGHCVCQQGVSGV 1167

Human  1172 RCDQCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQQTGVLGAFESSFWHMQE 1236
            |||||||||||.||.|.|||.|||||||:|||||.||:.|..||:|||.||:..|||..|..:::
Zfish  1168 RCDQCARGFSGTFPDCKPCHQCFGDWDRIVQDLATRTKALTDRAKELQTTGLTRAFERRFKELED 1232

Human  1237 KLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQDENFNANHALSGLE 1301
            .|...:.||.|||.:|.:...|:...|.||.:|||.|:.|.|.|.|||.|||.|:.|::|||.||
Zfish  1233 MLAQARDIVNARNATAEAVTTLMGMIEVLRAQIGETTDTLNQQEGDLTAVQDSNYEASNALSTLE 1297

Human  1302 RDRLALNLTLRQLDQHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPSPVSNSASARH 1366
            |:...|||...||::.||:||:|||||||||||.::::|.:||.|:|.|....||.||.||..|.
Zfish  1298 REAKELNLNADQLNRQLDILKNSNFLGAYDSIRASYNKSRDAEHRSNRSTTDTPSTVSQSADTRK 1362

Human  1367 RTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCGAPGDAPCATSPCGGAGCRDE 1431
            :||.|:..:::|||.|:.||:|.|..|:|....|.|..|||.||||||||.|..||||||||||:
Zfish  1363 KTERLIGQKRDDFNRKNAANKRTLTDLNAKVQNLDLKKINEKVCGAPGDAQCVDSPCGGAGCRDD 1427

Human  1432 DGQPRCGGLSCNGAAATADLALGRARHTQAELQRALAEGGSILSRVAETRRQASEAQQRAQAALD 1496
            :|:.|||||:||||.|.||.||.|::|.:.||.:|:.....:..:||:.:.:|.||:.||||||:
Zfish  1428 EGKRRCGGLNCNGAVAVADTALDRSKHAEKELDKAMGVVEELFKQVADAKTKAQEAKDRAQAALE 1492

Human  1497 KANASRGQVEQANQELQELIQSVKDFLNQEGADPDSIEMVATRVLELSIPASAEQIQHLAGAIAE 1561
            ||:.::.:|:.:|.:|::||:.::.||.||||||||||.||.||||||||||.:||:|||..|.:
Zfish  1493 KASDTKNKVDHSNNDLRDLIKQIRQFLMQEGADPDSIEAVANRVLELSIPASPKQIRHLADEIKD 1557

Human  1562 RVRSLADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQGAIR 1626
            ||:||::|||||.:|..|||:|||||.||::||:.||..|..||:|:.||.:|.|||..|:.||:
Zfish  1558 RVKSLSNVDAILEQTQNDVRKAEQLLLDAKKARNKAEGVKNTAESVKKALNDASRAQAAAEKAIQ 1622

Human  1627 GAVADTRDTEQTLYQVQERMAGAERALSSAGERARQLDALLEALKLKRAGNSLAASTAEETAGSA 1691
            .|..|...|:..|.|:|...:.:||.|:.|.:|...|:..:||||.|||.|||.|:.|||||..|
Zfish  1623 KAKNDIGLTQNQLAQIQSETSASERDLNDAVDRLGDLERQIEALKTKRANNSLDAARAEETATMA 1687

Human  1692 QGRAQEAEQLLRGPLGDQYQTVKALAERKAQGVLAAQARAEQLRDEARDLLQAAQDKLQRLQELE 1756
            :.:|.||:::|.|.|.|:|:||:.|.:.||:.:..|:.:||||||||:.||:.||||||||.|||
Zfish  1688 RDKANEAKEILDGELSDKYRTVQGLMDNKAKTMQDAKHKAEQLRDEAKGLLKDAQDKLQRLAELE 1752

Human  1757 GTYEENERALESKAAQLDGLEARMRSVLQAINLQVQIYNTCQ 1798
            ..||||::.||.||.||||||.:|:::|.|||.|:|||||||
Zfish  1753 KDYEENQKVLEGKARQLDGLEDKMKAILNAINRQIQIYNTCQ 1794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LAMB2	NP_002283.3	Laminin_N	57..281	CDD:278484	165/223 (74%)
		EGF_Lam	283..335	CDD:238012	39/51 (76%)
		EGF_Lam	347..399	CDD:238012	35/51 (69%)
		Laminin_EGF	410..467	CDD:278482	36/56 (64%)
		EGF_Lam	469..520	CDD:238012	32/50 (64%)
		EGF_Lam	521..562	CDD:238012	26/40 (65%)
		Laminin_EGF	783..831	CDD:278482	32/47 (68%)
		Laminin_EGF	831..879	CDD:278482	30/47 (64%)
		EGF_Lam	876..921	CDD:238012	27/44 (61%)
		EGF_Lam	926..984	CDD:238012	41/69 (59%)
		Laminin_EGF	986..>1028	CDD:278482	24/41 (59%)
		EGF_Lam	1037..1093	CDD:238012	34/55 (62%)
		Laminin_EGF	1095..1143	CDD:278482	30/47 (64%)
		Laminin_EGF	1143..>1182	CDD:278482	29/38 (76%)
		Domain II	1190..1409		111/218 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1338..1364		12/25 (48%)
		Domain alpha	1410..1442		24/31 (77%)
		Domain I	1443..1798		187/354 (53%)
		MA	1445..1701	CDD:214599	128/255 (50%)
		ATP-synt_B	<1453..1541	CDD:304375	39/87 (45%)
		HrpJ	1483..1670	CDD:301626	96/186 (52%)
		V-ATPase_G_2	1648..1755	CDD:293604	55/106 (52%)
		ATP-synt_B	<1680..1792	CDD:304375	62/111 (56%)
lamb2	XP_005162102.1	Laminin_N	41..265	CDD:278484	165/223 (74%)
		EGF_Lam	267..319	CDD:238012	39/51 (76%)
		EGF_Lam	331..383	CDD:238012	35/51 (69%)
		Laminin_EGF	394..451	CDD:278482	36/56 (64%)
		EGF_Lam	453..504	CDD:238012	32/50 (64%)
		EGF_Lam	506..544	CDD:214543	24/37 (65%)
		EGF_Lam	767..812	CDD:214543	30/44 (68%)
		Laminin_EGF	815..863	CDD:278482	30/47 (64%)
		EGF_Lam	860..905	CDD:238012	27/44 (61%)
		EGF_Lam	910..980	CDD:238012	41/69 (59%)
		Laminin_EGF	982..1027	CDD:278482	25/44 (57%)
		Laminin_EGF	1034..1088	CDD:278482	33/53 (62%)
		Laminin_EGF	1091..1139	CDD:278482	30/47 (64%)
		Laminin_EGF	1139..>1178	CDD:278482	29/38 (76%)
		FlgN	1228..1336	CDD:298847	52/107 (49%)
		MscS_porin	1471..1694	CDD:289559	115/222 (52%)
		DUF4795	1472..1620	CDD:292662	83/147 (56%)
		ApoLp-III_like	1571..1748	CDD:304399	87/176 (49%)
		PspA_IM30	1603..1786	CDD:281941	93/182 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332586
Domainoid	1	1.000	634	1.000	Domainoid score	I1473
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1723
Inparanoid	1	1.050	2306	1.000	Inparanoid score	I316
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D13713at7742
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		oto44482
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3531
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.340