DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LAMB2 and Lamb2

DIOPT Version :9

Sequence 1:	NP_002283.3	Gene:	LAMB2 / 3913	HGNCID:	6487	Length:	1798	Species:	Homo sapiens
Sequence 2:	NP_037106.1	Gene:	Lamb2 / 25473	RGDID:	2988	Length:	1801	Species:	Rattus norvegicus

Alignment Length:	1801	Identity:	1584/1801 - (87%)
Similarity:	1673/1801 - (92%)	Gaps:	3/1801 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MELTSRERGR---GQPLPWELRLGLLLSVLAATLAQAPAPDVPGCSRGSCYPATGDLLVGRADRL 62
            ||..|.:.||   |||:|||||||||||||||||||.|:.|||||||||||||||||||||||||
  Rat     1 MEWASGKPGRGRQGQPVPWELRLGLLLSVLAATLAQVPSLDVPGCSRGSCYPATGDLLVGRADRL 65

Human    63 TASSTCGLNGPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRRAAWWQSE 127
            ||||||||:.|||||||||||||||||||||||||||||||:||||||||||||||||.||||||
  Rat    66 TASSTCGLHSPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPNSHRIQNVVTSFAPQRRTAWWQSE 130

Human   128 NGIPAVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCGADFPGVPLA 192
            ||:|.||||||||||||||||||||||||||||||||||||||||.|||||||||||||||:|||
  Rat   131 NGVPMVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWRVYRYFSYDCGADFPGIPLA 195

Human   193 PPRHWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGD 257
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 PPRRWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGD 260

Human   258 NLLDPRREIREKYYYALYELVVRGNCFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCE 322
            |||||||||||||||||||||:|||||||||||:|||||||||||||||||||||||||||||||
  Rat   261 NLLDPRREIREKYYYALYELVIRGNCFCYGHASQCAPAPGAPAHAEGMVHGACICKHNTRGLNCE 325

Human   323 QCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCE 387
            ||||||:||||.||||||:||||||||:||:||||||||||||||||||||||||||||||||||
  Rat   326 QCQDFYQDLPWHPAEDGHTHACRKCECNGHSHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCE 390

Human   388 LCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQC 452
            |||||||||||||:||||.||.||||||||||||||||||||.||||||||||||||||||||||
  Rat   391 LCRPFFYRDPTKDMRDPAACRPCDCDPMGSQDGGRCDSHDDPVLGLVSGQCRCKEHVVGTRCQQC 455

Human   453 RDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLL 517
            ||||||||.|:..||:|||||:||||||.||||.:||:|:|||||||.|||||||||||||||||
  Rat   456 RDGFFGLSASNPRGCQRCQCNSRGTVPGGTPCDSSSGTCFCKRLVTGDGCDRCLPGHWGLSHDLL 520

Human   518 GCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGYFRPFLDHLIWEAEDTRGQVLDVV 582
            |||||||||||||||||||.||||.||.||:|||||||||||||||||||.||||...||||:||
  Rat   521 GCRPCDCDVGGALDPQCDEATGQCPCRPHMIGRRCEQVQPGYFRPFLDHLTWEAEGAHGQVLEVV 585

Human   583 ERLVTPGETPSWTGSGFVRLQEGQTLEFLVASVPKAMDYDLLLRLEPQVPEQWAELELIVQRPGP 647
            |||||..|||||||.|||||:|||.:||||.|:|:|||||||||.|||||||||||||:||||||
  Rat   586 ERLVTNRETPSWTGVGFVRLREGQEVEFLVTSLPRAMDYDLLLRWEPQVPEQWAELELVVQRPGP 650

Human   648 VPAHSLCGHLVPKDDRIQGTLQPHARYLIFPNPVCLEPGISYKLHLKLVRTGGSAQPETPYSGPG 712
            |.|||.|||::|:||||||.|.|:.|.|:||.|||||||:||||.|||..|||.|.|||||||.|
  Rat   651 VSAHSPCGHVLPRDDRIQGMLHPNTRVLVFPRPVCLEPGLSYKLKLKLTGTGGRAHPETPYSGSG 715

Human   713 LLIDSLVLLPRVLVLEMFSGGDAAALERQATFERYQCHEEGLVPSKTSPSEACAPLLISLSTLIY 777
            :|||||||.|.||:||||||||||||||:.|||||:||||||:||||..||||.|||||.|:|:|
  Rat   716 ILIDSLVLQPHVLMLEMFSGGDAAALERRTTFERYRCHEEGLMPSKTPLSEACVPLLISASSLVY 780

Human   778 NGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDLCAPGYYGFGPTGCQACQCSHEGALSSL 842
            ||||||||:||||||||||||||||.|||||||||||.||.|||||||.||||||||.:||||:|
  Rat   781 NGALPCQCDPQGSLSSECNPHGGQCRCKPGVVGRRCDACATGYYGFGPAGCQACQCSPDGALSAL 845

Human   843 CEKTSGQCLCRTGAFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLGCRDHTGGEHCER 907
            ||.|||||||||||||||||.|||||||||:||||||||.||||:.||||||||||:||||||||
  Rat   846 CEGTSGQCLCRTGAFGLRCDHCQRGQWGFPNCRPCVCNGRADECDAHTGACLGCRDYTGGEHCER 910

Human   908 CIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGH 972
            |||||||||||||||||||||||||||||||||||||:|.|||||||||||||||||||||||||
  Rat   911 CIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHRDGYSQQIVCHCRAGYTGLRCEACAPGH 975

Human   973 FGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHR 1037
            |||||:||||||||||||||||.||.|||||||||||||||||||||.|||||||||||||||||
  Rat   976 FGDPSKPGGRCQLCECSGNIDPTDPGACDPHTGQCLRCLHHTEGPHCGHCKPGFHGQAARQSCHR 1040

Human  1038 CTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRA 1102
            ||||||||:||:|||.|.||||||:|||||||:|||.|||||||||||.|||.||||||||||||
  Rat  1041 CTCNLLGTDPQRCPSTDLCHCDPSTGQCPCLPHVQGLSCDRCAPNFWNFTSGRGCQPCACHPSRA 1105

Human  1103 RGPTCNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPG 1167
            ||||||||||||||.|||||||||||||||||||||||.|||||.||||.|||||.|||||||||
  Rat  1106 RGPTCNEFTGQCHCHAGFGGRTCSECQELHWGDPGLQCRACDCDPRGIDKPQCHRSTGHCSCRPG 1170

Human  1168 VSGVRCDQCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQQTGVLGAFESSFW 1232
            |||||||||||||||:|||||||||||||||||||||||||:||||.|||||||||||||||||.
  Rat  1171 VSGVRCDQCARGFSGVFPACHPCHACFGDWDRVVQDLAARTRRLEQWAQELQQTGVLGAFESSFL 1235

Human  1233 HMQEKLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQDENFNANHAL 1297
            ::|.|||:||.||.||||||||||:||||||.||.|||:.||.||||||:|||||||||||||||
  Rat  1236 NLQGKLGMVQAIVAARNTSAASTAKLVEATEGLRHEIGKTTERLTQLEAELTDVQDENFNANHAL 1300

Human  1298 SGLERDRLALNLTLRQLDQHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPSPVSNSA 1362
            ||||||.|||||||||||||||:||||||||||||||||||||.|||||||.|..|:||||||||
  Rat  1301 SGLERDGLALNLTLRQLDQHLDILKHSNFLGAYDSIRHAHSQSTEAERRANASTFAIPSPVSNSA 1365

Human  1363 SARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCGAPGDAPCATSPCGGAG 1427
            ..|.|.|.||.||:|:||.:|:|||:|||:||.||||||||.:||||||||||||||||||||||
  Rat  1366 DTRRRAEVLMGAQRENFNRQHLANQQALGRLSTHTHTLSLTGVNELVCGAPGDAPCATSPCGGAG 1430

Human  1428 CRDEDGQPRCGGLSCNGAAATADLALGRARHTQAELQRALAEGGSILSRVAETRRQASEAQQRAQ 1492
            |||||||||||||.|:||||||||||||||||||||||||.|||.|||||:||||||.|||||||
  Rat  1431 CRDEDGQPRCGGLGCSGAAATADLALGRARHTQAELQRALVEGGGILSRVSETRRQAEEAQQRAQ 1495

Human  1493 AALDKANASRGQVEQANQELQELIQSVKDFLNQEGADPDSIEMVATRVLELSIPASAEQIQHLAG 1557
            ||||||||||||||||||||:||||:|||||:|||||||||||||||||::|||||.||||.||.
  Rat  1496 AALDKANASRGQVEQANQELRELIQNVKDFLSQEGADPDSIEMVATRVLDISIPASPEQIQRLAS 1560

Human  1558 AIAERVRSLADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQ 1622
            .||||||||||||.|||.|:|||||||||||||:||||.||.|:||||||||||||||||||.||
  Rat  1561 EIAERVRSLADVDTILAHTMGDVRRAEQLLQDAQRARSRAEGERQKAETVQAALEEAQRAQGAAQ 1625

Human  1623 GAIRGAVADTRDTEQTLYQVQERMAGAERALSSAGERARQLDALLEALKLKRAGNSLAASTAEET 1687
            |||||||.||::|||||.||||||||.|::|:||.||||||.|||||||||||||||||||||||
  Rat  1626 GAIRGAVVDTKNTEQTLQQVQERMAGTEQSLNSASERARQLHALLEALKLKRAGNSLAASTAEET 1690

Human  1688 AGSAQGRAQEAEQLLRGPLGDQYQTVKALAERKAQGVLAAQARAEQLRDEARDLLQAAQDKLQRL 1752
            |||||.||:|||:.||..:|||||||:|||||||:|||||||||||||||||.||||||||||||
  Rat  1691 AGSAQSRAREAEKQLREQVGDQYQTVRALAERKAEGVLAAQARAEQLRDEARGLLQAAQDKLQRL 1755

Human  1753 QELEGTYEENERALESKAAQLDGLEARMRSVLQAINLQVQIYNTCQ 1798
            ||||||||||||.||.||||||||||||||||||||||||||||||
  Rat  1756 QELEGTYEENERELEVKAAQLDGLEARMRSVLQAINLQVQIYNTCQ 1801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LAMB2	NP_002283.3	Laminin_N	57..281	CDD:278484	213/223 (96%)
		EGF_Lam	283..335	CDD:238012	49/51 (96%)
		EGF_Lam	347..399	CDD:238012	49/51 (96%)
		Laminin_EGF	410..467	CDD:278482	51/56 (91%)
		EGF_Lam	469..520	CDD:238012	43/50 (86%)
		EGF_Lam	521..562	CDD:238012	36/40 (90%)
		Laminin_EGF	783..831	CDD:278482	42/47 (89%)
		Laminin_EGF	831..879	CDD:278482	41/47 (87%)
		EGF_Lam	876..921	CDD:238012	40/44 (91%)
		EGF_Lam	926..984	CDD:238012	54/57 (95%)
		Laminin_EGF	986..>1028	CDD:278482	38/41 (93%)
		EGF_Lam	1037..1093	CDD:238012	46/55 (84%)
		Laminin_EGF	1095..1143	CDD:278482	45/47 (96%)
		Laminin_EGF	1143..>1182	CDD:278482	35/38 (92%)
		Domain II	1190..1409		179/218 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1338..1364		20/25 (80%)
		Domain alpha	1410..1442		31/31 (100%)
		Domain I	1443..1798		310/354 (88%)
		MA	1445..1701	CDD:214599	222/255 (87%)
		ATP-synt_B	<1453..1541	CDD:304375	80/87 (92%)
		HrpJ	1483..1670	CDD:301626	158/186 (85%)
		V-ATPase_G_2	1648..1755	CDD:293604	90/106 (85%)
		ATP-synt_B	<1680..1792	CDD:304375	99/111 (89%)
Lamb2	NP_037106.1	Laminin_N	60..284	CDD:278484	213/223 (96%)
		EGF_Lam	286..338	CDD:238012	49/51 (96%)
		EGF_Lam	350..402	CDD:238012	49/51 (96%)
		Laminin_EGF	413..470	CDD:278482	51/56 (91%)
		EGF_Lam	472..523	CDD:238012	43/50 (86%)
		EGF_Lam	524..565	CDD:238012	36/40 (90%)
		EGF_Lam	786..831	CDD:214543	39/44 (89%)
		Laminin_EGF	834..882	CDD:278482	41/47 (87%)
		Laminin_EGF	880..927	CDD:278482	42/46 (91%)
		EGF_Lam	929..987	CDD:238012	54/57 (95%)
		Laminin_EGF	989..>1031	CDD:278482	38/41 (93%)
		Laminin_EGF	1041..1095	CDD:278482	44/53 (83%)
		Laminin_EGF	1098..1146	CDD:278482	45/47 (96%)
		Laminin_EGF	1146..>1185	CDD:278482	35/38 (92%)
		Domain II	1193..1412		179/218 (82%)
		Domain alpha	1413..1445		31/31 (100%)
		Domain I	1446..1801		310/354 (88%)
		DUF4398	<1446..1516	CDD:291044	64/69 (93%)
		flagell_FliJ	1477..1617	CDD:131526	121/139 (87%)
		HrpJ	1485..1673	CDD:301626	159/187 (85%)
		MscS_porin	1582..1776	CDD:289559	166/193 (86%)
		ATP-synt_B	<1684..1795	CDD:304375	98/110 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1684..1703		16/18 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83686057
Domainoid	1	1.000	1024	1.000	Domainoid score	I1448
eggNOG	1	0.900	-	-		E1_KOG0994
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1723
Inparanoid	1	1.050	3385	1.000	Inparanoid score	I375
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D10059at32523
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		oto134718
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310