DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LAMB2 and lam-1

DIOPT Version :9

Sequence 1:	NP_002283.3	Gene:	LAMB2 / 3913	HGNCID:	6487	Length:	1798	Species:	Homo sapiens
Sequence 2:	NP_500734.3	Gene:	lam-1 / 177292	WormBaseID:	WBGene00002247	Length:	1790	Species:	Caenorhabditis elegans

Alignment Length:	1844	Identity:	731/1844 - (39%)
Similarity:	1036/1844 - (56%)	Gaps:	115/1844 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    12 QPLPWELRLGLLLSVLAATL-AQAP-APDVPGCSRGSCYPATGDLLVGRADRLTASSTCGLNGPQ 74
            :|..|   ||||||:|...: ||.| ..:...|...||||.||:||:||..:|.|:||||..|.|
Worm     3 RPPFW---LGLLLSLLLVFIEAQHPLQQNEDRCQDRSCYPITGNLLIGRKSQLKATSTCGSQGRQ 64

Human    75 PYCIVSHLQDEKKCFLCDSRRPFSARDNPH--SHRIQNVVTSFAPQRRAAWWQSENGIPAVTIQL 137
            .:||||||:::.|||.||||..:..:..|:  ||||:||||.....:...|:|||||...|:|..
Worm    65 RFCIVSHLEEQTKCFYCDSRTEWKPQREPYRLSHRIENVVTEVMDDKNRNWYQSENGAQNVSISF 129

Human   138 DLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCGADFPGVPLAPPRHWDDVVC 202
            ||||||||||||||||:||||||::|||||||:||.|||||:|||.:.|||:|..||:...||:|
Worm   130 DLEAEFHFTHLIMTFKSFRPAAMIIERSADFGKTWQVYRYFAYDCDSSFPGIPEGPPKKHTDVIC 194

Human   203 ESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGDNLLDPRREIR 267
            .|:||::.|||.||::|:|:.|.|...:||:..|..||||||||.|.|:||||||:|||.|.||.
Worm   195 TSQYSDVAPSTGGEIVYKVISPHIVTENPYADEISTLLKITNLRFNFTKLHTLGDDLLDYRPEID 259

Human   268 EKYYYALYELVVRGNCFCYGHASECAP-----APGAPAHAEGMVHGACICKHNTRGLNCEQCQDF 327
            ||||||:||:||||:|.||||||.|.|     :|........:|||.|.|.|||.|||||:|:.|
Worm   260 EKYYYAIYEIVVRGSCSCYGHASRCIPIDPHVSPNTVMERADIVHGRCECMHNTEGLNCEKCKAF 324

Human   328 YRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPF 392
            |.|||||||.....:.||:|.|:.|...||||.|||.:||.|||||||.|.|||.|::||.|:||
Worm   325 YNDLPWRPAIGDEKNECRQCNCNRHALRCHFDRAVYESSGFVSGGVCDDCMHNTQGKNCEQCKPF 389

Human   393 FYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFF 457
            |||||.:.:.||.||..|:||..|||:.|.|:..:|...|||:|:|.||.:|.|.||.:|::|::
Worm   390 FYRDPRRTIDDPHVCLPCECDKAGSQNKGICEGEEDAERGLVAGKCYCKTNVDGNRCDRCKNGYW 454

Human   458 GLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPC 522
            .|:.::..||..|.||..||. .:..||..:|.|.|||||||..||:|||.|:|||..:.||:.|
Worm   455 NLTETNVDGCVACTCNLLGTY-NNEGCDKYTGMCTCKRLVTGENCDQCLPEHYGLSEHVDGCKAC 518

Human   523 DCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGYFRPFLDHLIWEAED---TRGQVLDVVER 584
            |||:||:.|..|:..||||.||:...|||||.....::...:.|.::|||.   |||:|
Worm   519 DCDIGGSYDNTCEITTGQCKCREGFSGRRCETADSSFYCADITHYVYEAEYANLTRGEV------ 577

Human   585 LVTPGETPSW---------TGSGFVRLQEGQTLEFLVASVPKAMDYDLLLRLE-PQVPEQWAELE 639
                 :|..|         ||.||.:..|| |:..:...|..:..|::::|.: .:.|..|..::
Worm   578 -----KTREWPSQPHEQTFTGEGFAQAVEG-TIITVNPIVEVSQKYNVIIRHDGARDPVGWENIQ 636

Human   640 LIVQRPGPVPAHSLCGHLVPKDDRIQGTLQPHARYLIFPNPVCLEPGISYKLHLKLVRTGGSAQP 704
            :.|.|| .......|....|.||.:...:.|.:||:.....:|||.|:.|:|.::.....|::.|
Worm   637 ITVVRP-EAEGDGSCSDAPPSDDFLIARIYPGSRYIEVQPAICLEAGVQYELRIQFNEKRGNSHP 700

Human   705 ETPYSGPGLLIDSLVLLPRVLVLEMFSGGDAAALERQATFERYQCHEEGLVPS--KTSPSEACAP 767
            : ..:...:||||::|.|....|.:|. |.|.|.:....:.||||....|..|  |...:|.|..
Worm   701 Q-ERAAANILIDSILLAPPTSELHIFQ-GSARAEQHLTEYNRYQCRHLALSLSLFKDQRNEVCER 763

Human   768 LLISLSTLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDLCAPGYYGFGPTGCQACQ 832
            .:..::..:.|....|.|:..||:|..||..||||.|||.|||||||.||.|.|||||:||:.|.
Worm   764 YVCPIAAALLNKTSECNCDATGSVSGICNVQGGQCECKPNVVGRRCDQCAIGTYGFGPSGCKKCD 828

Human   833 CSHEGALSSLCEKTSGQCLCR-TGAFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLGC 896
            |...|:|.:.|:|.||||:|| .|.:|.:|::||.|.||||.||.|.||.||:.|:..:|||:.|
Worm   829 CDAVGSLGNDCDKQSGQCVCREKGIYGRQCNQCQPGFWGFPECRTCQCNDHANICDQSSGACIEC 893

Human   897 RDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCH---QDEYSQQIVCHCRA 958
            ||.|.|.:|:||..|::|||||..|..|:|||||.||.|....|.:|:   ....:|.|||:|::
Worm   894 RDLTTGHYCDRCQDGYYGDPRLGVGIPCKPCPCPGGPTSGYQHADTCYLRNSGNNTQDIVCNCKS 958

Human   959 GYTGLRCEACAPGHFGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCAHCK 1023
            ||.|.||..||..|:|.|...||.|:.|:|:||||.....:||..||:||:|||||||..|.||.
Worm   959 GYQGERCGECAQNHWGSPREVGGTCERCDCNGNIDMAMEGSCDAATGECLKCLHHTEGAQCEHCV 1023

Human  1024 PGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTS 1088
            .|::|.|..::|.||.||.||||..:..      ||..||||||..|:.|..||:||.|.:||.|
Worm  1024 DGYYGDAKLKTCQRCVCNELGTNSTKGA------CDRVSGQCPCHDNIIGMQCDQCAENHFNLAS 1082

Human  1089 GHGCQPCACHPSRARGPT----------CNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQ--CH 1141
            |.||:.|.|.   :.|..          ||.|.|||.|:.|.|||.|.:|::|:||||...  ||
Worm  1083 GAGCEACGCD---SNGVVLNHEGVPHLQCNIFDGQCQCKPGRGGRKCDQCEDLYWGDPTTPDGCH 1144

Human  1142 ACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQCARGFSGIFPACHPCHACFGDWDRVVQDLAA 1206
            .|:|:..|..:.||||..|.|.|:.|..|..|::||||::|.:|.|:||..||..||.::|.|..
Worm  1145 RCECNPTGSKSLQCHRNNGTCECQAGSGGALCNECARGYTGQWPYCNPCGECFHQWDNIMQKLQK 1209

Human  1207 RTQRLEQRAQELQQTGVLGAFESSFWHMQEKLGIVQGIVGARNTSAASTAQLVEATEELRREIGE 1271
            :...|...|..::.|||..|:::.|..|:|.|...:..:...|.|.....::.:....|::::..
Worm  1210 QVHALIDTANNIEDTGVASAYDADFEKMEETLKETKKALSDANISKEDIEEMSKKLALLKKQVIA 1274

Human  1272 ATEHLTQLEADLTDVQDENFNANHALSGLERDRLALNLTLRQLDQHLDLLKHSNFLGAYDSIRHA 1336
            ..|.|..:|..::::......|...|..|:::...:.....:|:.....:|.::.|||::..|.:
Worm  1275 GREKLGAIETRISNITQAVDFAQKDLEHLQKEVDKVTKATIELEDKASKIKEADVLGAFNITRES 1339

Human  1337 HSQSAEAERRANTSALAVPSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLS 1401
            .|:|.:|:||.: :|:...:...|.|.   |...|::..|.||..:::.|:.||.:.......|.
Worm  1340 ASKSLDAQRRTD-AAIGKLAAAENQAL---RASELLEKNKNDFEKQYVENEEALNEAETLLGGLE 1400

Human  1402 --LTDINELVCGAPGDAPCATSPCGGAG-CRDEDGQPRCGGLSC-NGAAATADLALGRARHTQAE 1462
              |..:||.|||| ..||| .:.|||.| |      ..|||.|| .||.:.|:.|...|......
Worm  1401 SVLPKLNEQVCGA-SSAPC-DALCGGPGSC------GFCGGQSCMEGAVSKANQAKSFATEADTR 1457

Human  1463 LQRALAEGGSILSRVAETRRQASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQEG 1527
            |.....|...:||.|.:...:.::|:.:|:.|.:.|..:..:...:..||.::.:.:.:||..:.
Worm  1458 LDEKQKEAEEVLSIVRDVLTETTKAKAKAEKAYEVAKNTAQRANSSRAELDKIAEEIGEFLTAQK 1522

Human  1528 ADPDSIEMVATRVLELSIPASAEQIQHLAGAIAERVRSLADVDAILARTVGDVRRAEQLLQDARR 1592
            :.|:.|..:|..||...|..:.:||..|.|.|.|.:..:.::|.||..|.|:...|..|...|.:
Worm  1523 SSPEQIRNLAEEVLGKEISLTPDQITDLTGKIKESLAKINNIDEILNETRGNKSIAANLESRAVK 1587

Human  1593 ARSWAEDEKQKAETVQAALEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQERMAGAERALSSAG 1657
            |       .::||.:|.|:||.:.|..:|..|.....:...:.:....|.:|.:..|..:..:..
Worm  1588 A-------NKEAELLQKAMEEIREALQLADQAYNNVTSVLEEIDTMQVQARELIDKARNSTEAVE 1645

Human  1658 ERAR-------QLDALLEALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLRGPLGDQYQT--- 1712
            .:|:       :|:.::..:|::....|.:|..|..|..:|...|..|||     ...|.||
Worm  1646 GKAQAANTTLAELEGVMSGVKVEYLQISESAKNALTTVDAALAAATNAEQ-----KNKQIQTDLE 1705

Human  1713 -VKALAERKAQGVLAAQARAEQLRDEARDLLQAAQ---DKLQRLQELEGTYEENERALESKAAQL 1773
             ...|.|::.:|.:|.|.|||:||:.|..||..||   |.:..|.:     :..|..|:.....|
Worm  1706 RATELLEKRMEGNVAPQQRAEKLRERAAKLLYQAQRHNDDIDNLSK-----DSTEMRLDDYETIL 1765

Human  1774 DGLEARMRSVLQAINLQVQIYNTC 1797
            ..|.:|:..|.:.|:.:...:.||
Worm  1766 ADLNSRLERVTRDIHEKTDFHATC 1789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LAMB2	NP_002283.3	Laminin_N	57..281	CDD:278484	135/225 (60%)
		EGF_Lam	283..335	CDD:238012	30/56 (54%)
		EGF_Lam	347..399	CDD:238012	34/51 (67%)
		Laminin_EGF	410..467	CDD:278482	23/56 (41%)
		EGF_Lam	469..520	CDD:238012	26/50 (52%)
		EGF_Lam	521..562	CDD:238012	19/40 (48%)
		Laminin_EGF	783..831	CDD:278482	31/47 (66%)
		Laminin_EGF	831..879	CDD:278482	25/48 (52%)
		EGF_Lam	876..921	CDD:238012	23/44 (52%)
		EGF_Lam	926..984	CDD:238012	27/60 (45%)
		Laminin_EGF	986..>1028	CDD:278482	23/41 (56%)
		EGF_Lam	1037..1093	CDD:238012	28/55 (51%)
		Laminin_EGF	1095..1143	CDD:278482	23/59 (39%)
		Laminin_EGF	1143..>1182	CDD:278482	17/38 (45%)
		Domain II	1190..1409		52/220 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1338..1364		8/25 (32%)
		Domain alpha	1410..1442		14/32 (44%)
		Domain I	1443..1798		92/369 (25%)
		MA	1445..1701	CDD:214599	61/262 (23%)
		ATP-synt_B	<1453..1541	CDD:304375	17/87 (20%)
		HrpJ	1483..1670	CDD:301626	43/193 (22%)
		V-ATPase_G_2	1648..1755	CDD:293604	33/120 (28%)
		ATP-synt_B	<1680..1792	CDD:304375	35/118 (30%)
lam-1	NP_500734.3	LamNT	31..273	CDD:214532	144/241 (60%)
		EGF_Lam	274..332	CDD:238012	30/57 (53%)
		EGF_Lam	344..396	CDD:238012	34/51 (67%)
		Laminin_EGF	407..464	CDD:278482	23/56 (41%)
		EGF_Lam	466..516	CDD:238012	26/50 (52%)
		EGF_Lam	517..>556	CDD:238012	19/38 (50%)
		EGF_Lam	779..824	CDD:214543	29/44 (66%)
		Laminin_EGF	827..876	CDD:278482	25/48 (52%)
		Laminin_EGF	874..913	CDD:278482	19/38 (50%)
		Laminin_EGF	924..983	CDD:278482	26/58 (45%)
		EGF_Lam	985..1030	CDD:238012	24/44 (55%)
		Laminin_EGF	1038..1086	CDD:278482	26/53 (49%)
		EGF_Lam	1088..1144	CDD:238012	21/58 (36%)
		EGF_Lam	1145..1193	CDD:238012	20/47 (43%)
		BAR	1197..>1327	CDD:299863	26/129 (20%)
		DUF1002	<1448..1565	CDD:303039	26/116 (22%)
		BAR	1581..1788	CDD:299863	54/223 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	315	1.000	Domainoid score	I764
eggNOG	1	0.900	-	-		E1_KOG0994
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1723
Inparanoid	1	1.050	1422	1.000	Inparanoid score	I55
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D42471at33208
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		otm16253
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3531
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870