DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LAMB2 and lamb2

DIOPT Version :9

Sequence 1:	NP_002283.3	Gene:	LAMB2 / 3913	HGNCID:	6487	Length:	1798	Species:	Homo sapiens
Sequence 2:	XP_004914156.1	Gene:	lamb2 / 100485566	XenbaseID:	XB-GENE-5935962	Length:	1793	Species:	Xenopus tropicalis

Alignment Length:	1798	Identity:	1074/1798 - (59%)
Similarity:	1373/1798 - (76%)	Gaps:	19/1798 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    13 PLPWELRLGLLLSVL-AATLAQAPAPDVPGCSRGSCYPATGDLLVGRADRLTASSTCGLNGPQPY 76
            |..|.  .|::::.| ..:|:|.| ....|||:||||||||||||||||:|.|:|||||...|||
Frog     3 PSLWP--FGIVITALVTGSLSQIP-DQQHGCSQGSCYPATGDLLVGRADKLKATSTCGLRRAQPY 64

Human    77 CIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRRAAWWQSENGIPAVTIQLDLEA 141
            |||||||||||||:||||:|::...||.||||:||:|:|||.|:.||||||||:.||||||||||
Frog    65 CIVSHLQDEKKCFVCDSRKPYNPLYNPISHRIENVITTFAPHRKKAWWQSENGVSAVTIQLDLEA 129

Human   142 EFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCGADFPGVPLAPPRHWDDVVCESRY 206
            |||||||||||||||||||||||||||||||..||||.:||.:.||.|..:..|..|:|:|||||
Frog   130 EFHFTHLIMTFKTFRPAAMLVERSADFGRTWQAYRYFGHDCASSFPNVSRSALRKVDEVICESRY 194

Human   207 SEIEPSTEGEVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYY 271
            |:||||||||||||||||||||.|||...|||||||||||:|.|:||||||||||.|.||:||||
Frog   195 SDIEPSTEGEVIYRVLDPAIPIRDPYGPNIQNLLKITNLRINFTKLHTLGDNLLDSRVEIKEKYY 259

Human   272 YALYELVVRGNCFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPA 336
            |||||||||||||||||||||||..|.....||||||.|:|||||:|||||||...:.|||||||
Frog   260 YALYELVVRGNCFCYGHASECAPIQGVSRDVEGMVHGRCVCKHNTKGLNCEQCDSSFNDLPWRPA 324

Human   337 EDGHSHACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDL 401
            |...::||:||.|:.|:..|||||||||::|||||||||.|.|||.||:||||:||||:||:|||
Frog   325 EGRSTNACKKCNCNNHSRKCHFDMAVYLSTGNVSGGVCDDCVHNTMGRNCELCKPFFYKDPSKDL 389

Human   402 RDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLG 466
            ||.|||::|||||.||.|||.|||.|:|||||::||||||::|.|.||.:|:.||||||.::..|
Frog   390 RDSAVCKACDCDPDGSLDGGLCDSLDNPALGLIAGQCRCKDYVEGPRCDRCKTGFFGLSTNNFQG 454

Human   467 CRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALD 531
            |:||||:.|||:.....|||.||.|:|||.||||.|::|||..|.|||||.|||.||||:|||.|
Frog   455 CQRCQCDPRGTISDGAQCDPISGDCFCKRFVTGRTCNQCLPEFWALSHDLHGCRSCDCDIGGAWD 519

Human   532 PQCDEGTGQCHCRQHMVGRRCEQVQPGYFRPFLDHLIWEAEDT-RGQVLDVVERLVTPGETPSWT 595
            ..|...||||.||.|||||:|.||:.||:|..|||..:|||.. ..|...|:||....|...:||
Frog   520 NHCATETGQCRCRSHMVGRQCNQVKSGYYRIHLDHYTYEAESALHRQGCSVLERERLIGRPATWT 584

Human   596 GSGFVRLQEGQTLEFLVASVPKAMDYDLLLRLEPQVPEQWAELELIVQRPGPVPAHSLCGHLVPK 660
            |.||..:.||..|||.::::|.:|:||:::|.|||:|..|.::::.|.||||:|..|.||:.:|.
Frog   585 GPGFALVPEGGILEFQISNIPYSMEYDVIIRYEPQLPATWEQVKISVIRPGPIPTSSPCGNTIPA 649

Human   661 DDRIQGTLQPHARYLIFPNPVCLEPGISYKLHLKLVRTGGSAQPETPYSGPGLLIDSLVLLPRVL 725
            ||.:..:|.|..|:::.|.|||||.|:||.:.|:..|.  |.:.:.|  ...:|||||||:||..
Frog   650 DDLMVASLPPGTRHVVLPQPVCLERGVSYTIRLEFSRY--SLREKIP--SANILIDSLVLVPRYS 710

Human   726 VLEMFSGGDAAALERQATFERYQCHEEGLVPSKTSPSEACAPLLISLSTLIYNGALPCQCNPQGS 790
            .:|||..||.|:::|:.|||||:||.......|:|.:|.|:.|:.|:|.:|:.|||||.|:||||
Frog   711 SMEMFIAGDPASIQRKETFERYRCHSNSGNVIKSSTTEVCSGLITSMSAIIHEGALPCSCDPQGS 775

Human   791 LSSECNPHGGQCLCKPGVVGRRCDLCAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTG 855
            |||||:|:||||.||..|:|:|||.||||.:|||||||:||:|:.||:..:.|::.:|||.||.|
Frog   776 LSSECDPNGGQCQCKANVIGQRCDRCAPGTHGFGPTGCKACECNMEGSTHNFCDQRTGQCPCRPG 840

Human   856 AFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLGCRDHTGGEHCERCIAGFHGDPRLPY 920
            |||.||||||.|.||||:||.|.||||::||:..|||||.||||:.|:.||||.|||:|:|.|..
Frog   841 AFGSRCDRCQPGHWGFPNCRQCQCNGHSEECDQRTGACLNCRDHSTGDRCERCTAGFYGNPILGS 905

Human   921 GGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGL----------RCEACAPGHFGD 975
            |..||||||||||.|.||:|.|||||..|:|::|:|:.|||||          |||.|:||.||:
Frog   906 GDHCRPCPCPEGPNSGRHYAASCHQDPRSRQVICNCKQGYTGLVKRAMGLRRPRCEECSPGFFGN 970

Human   976 PSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHRCTC 1040
            |.:.||||.||:|:.|||..|...||..:||||:|.::|||..|.||:.||:|.|:|::|.:|||
Frog   971 PFQTGGRCLLCQCNNNIDMTDIGGCDRRSGQCLKCKYNTEGRFCEHCRIGFYGDASRRNCRKCTC 1035

Human  1041 NLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGP 1105
            |.|||.|.||||.:.|.||.:||||.|||||:|.:||||:|:||||.||.|||||.|.|:.:...
Frog  1036 NYLGTEPSQCPSREDCMCDRTSGQCLCLPNVRGQNCDRCSPHFWNLASGKGCQPCNCDPNHSFSL 1100

Human  1106 TCNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVSG 1170
            :||||||:|.||.||||.||::|||.:||:|.:||.|||||.|||..|||:|.:|||.||.||||
Frog  1101 SCNEFTGKCQCRPGFGGLTCTDCQENYWGNPNIQCRACDCDRRGIKAPQCNRASGHCDCRAGVSG 1165

Human  1171 VRCDQCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQQTGVLGAFESSFWHMQ 1235
            ||||||||||||.||.|.|||.|||||||:|||||.||:.|.||.:::||:||.|.::.:|..::
Frog  1166 VRCDQCARGFSGQFPDCQPCHQCFGDWDRIVQDLATRTKSLVQRGKDIQQSGVAGVYQKNFREIE 1230

Human  1236 EKLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQDENFNANHALSGL 1300
            :||...||||.|||.:|.|..:|::..::||.:|.|:||.|||||.:||.||||||:|||.|:.|
Frog  1231 KKLAKAQGIVNARNATAESVTKLMKIMDDLRNKINESTEALTQLEGELTAVQDENFDANHDLAEL 1295

Human  1301 ERDRLALNLTLRQLDQHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPSPVSNSASAR 1365
            |||..:||:|.::....||:||:||||||||||:.:|::|.:||::||.:...||||||:||..|
Frog  1296 ERDARSLNMTAKERSHQLDVLKNSNFLGAYDSIQQSHAKSRQAEKQANNATTNVPSPVSDSARTR 1360

Human  1366 HRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCGAPGDAPCATSPCGGAGCRD 1430
            .:|:.|:..:::|||.|:.||:|||..|:|.|.||.:..|||.||||||||||:.||||||||||
Frog  1361 EKTQQLITHKRDDFNRKNAANRRALNDLAAKTDTLDMKKINEKVCGAPGDAPCSESPCGGAGCRD 1425

Human  1431 EDGQPRCGGLSCNGAAATADLALGRARHTQAELQRALAEGGSILSRVAETRRQASEAQQRAQAAL 1495
            ::|:..||||:||||.||||.|||||||.:.|||:||.|...:..:|||.:.:|..|:|||||.|
Frog  1426 DEGKRHCGGLNCNGAVATADNALGRARHAEEELQKALGEVEVLFQKVAEAKVKADRAKQRAQATL 1490

Human  1496 DKANASRGQVEQANQELQELIQSVKDFLNQEGADPDSIEMVATRVLELSIPASAEQIQHLAGAIA 1560
            |:||.::.:|||:|:||:||||.:||||||||||||||||||:|||:|:|||:.:|||.||..|.
Frog  1491 DRANETKARVEQSNKELRELIQQIKDFLNQEGADPDSIEMVASRVLDLTIPATPKQIQRLAEEIK 1555

Human  1561 ERVRSLADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQGAI 1625
            :||::||:|||||.:|..|||:|||||.:|:||::.||:.|..||:|:.||::|:|||..|:|||
Frog  1556 DRVKTLANVDAILDQTAADVRKAEQLLHEAKRAKNRAENVKNTAESVKRALDDARRAQNAAEGAI 1620

Human  1626 RGAVADTRDTEQTLYQVQERMAGAERALSSAGERARQLDALLEALKLKRAGNSLAASTAEETAGS 1690
            :.|..|.:|||:.|..:|...:.||..|:.|.:|...||..::.||:|||.||||||.|||:|.:
Frog  1621 QSANDDIKDTERKLTAIQTATSSAENQLNDAMDRVGNLDKQIDGLKMKRANNSLAASRAEESATA 1685

Human  1691 AQGRAQEAEQLLRGPLGDQYQTVKALAERKAQGVLAAQARAEQLRDEARDLLQAAQDKLQRLQEL 1755
            |..:|.:|:::|.|.|.|:|:||:.:.:|||:.:..|:.:|:||:|||:.||:.|||||:|||:|
Frog  1686 ALDKANDAKKILEGQLADKYKTVQNVVDRKAKNIKEAKTKADQLQDEAKKLLENAQDKLKRLQDL 1750

Human  1756 EGTYEENERALESKAAQLDGLEARMRSVLQAINLQVQIYNTCQ 1798
            |..|.:||:.|:.||.:|:|||.:|:.:|.|||.|:|||||||
Frog  1751 EVEYTKNEKLLQDKAKRLNGLEDKMKEILHAINQQIQIYNTCQ 1793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LAMB2	NP_002283.3	Laminin_N	57..281	CDD:278484	173/223 (78%)
		EGF_Lam	283..335	CDD:238012	36/51 (71%)
		EGF_Lam	347..399	CDD:238012	37/51 (73%)
		Laminin_EGF	410..467	CDD:278482	36/56 (64%)
		EGF_Lam	469..520	CDD:238012	31/50 (62%)
		EGF_Lam	521..562	CDD:238012	25/40 (63%)
		Laminin_EGF	783..831	CDD:278482	34/47 (72%)
		Laminin_EGF	831..879	CDD:278482	28/47 (60%)
		EGF_Lam	876..921	CDD:238012	27/44 (61%)
		EGF_Lam	926..984	CDD:238012	38/67 (57%)
		Laminin_EGF	986..>1028	CDD:278482	21/41 (51%)
		EGF_Lam	1037..1093	CDD:238012	37/55 (67%)
		Laminin_EGF	1095..1143	CDD:278482	26/47 (55%)
		Laminin_EGF	1143..>1182	CDD:278482	30/38 (79%)
		Domain II	1190..1409		115/218 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1338..1364		13/25 (52%)
		Domain alpha	1410..1442		24/31 (77%)
		Domain I	1443..1798		194/354 (55%)
		MA	1445..1701	CDD:214599	142/255 (56%)
		ATP-synt_B	<1453..1541	CDD:304375	55/87 (63%)
		HrpJ	1483..1670	CDD:301626	103/186 (55%)
		V-ATPase_G_2	1648..1755	CDD:293604	52/106 (49%)
		ATP-synt_B	<1680..1792	CDD:304375	55/111 (50%)
lamb2	XP_004914156.1	Laminin_N	49..269	CDD:365840	169/219 (77%)
		EGF_Lam	271..323	CDD:238012	36/51 (71%)
		Laminin_EGF	335..391	CDD:365839	40/55 (73%)
		Laminin_EGF	398..455	CDD:365839	36/56 (64%)
		EGF_Lam	457..508	CDD:238012	31/50 (62%)
		EGF_Lam	509..549	CDD:238012	25/39 (64%)
		EGF_Lam	768..813	CDD:214543	32/44 (73%)
		Laminin_EGF	816..864	CDD:365839	28/47 (60%)
		EGF_Lam	862..906	CDD:238012	27/43 (63%)
		EGF_Lam	911..976	CDD:238012	35/64 (55%)
		EGF_Lam	981..1029	CDD:238012	24/47 (51%)
		Laminin_EGF	1033..1088	CDD:365839	37/54 (69%)
		Laminin_EGF	1090..1138	CDD:365839	26/47 (55%)
		EGF_Lam	1138..1182	CDD:214543	34/43 (79%)
		Smc	1219..>1791	CDD:224117	310/571 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	524	1.000	Domainoid score	I3349
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1723
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D10059at32523
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.030