DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNMaR and gpr139

DIOPT Version :9

Sequence 1:	NP_001027122.2	Gene:	CNMaR / 39127	FlyBaseID:	FBgn0053696	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001352082.1	Gene:	gpr139 / 798482	ZFINID:	ZDB-GENE-050823-2	Length:	363	Species:	Danio rerio

Alignment Length:	399	Identity:	88/399 - (22%)
Similarity:	140/399 - (35%)	Gaps:	128/399 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 IGHFVHQYYIPVLCCTGSIGNILSVFVFFRTKLRKLSSSF-YLAALAVSDTCFLAGLFAQWLNFL 120
            :|.|...||..:| |.|...|||:|.:..:..||:..||: ||.||||:|...|  |...:::||
Zfish    24 LGQFPVVYYSSLL-CLGLPANILTVIILSQLVLRRQKSSYNYLLALAVADILVL--LLIVFVDFL 85

  Fly   121 NVDI-------YNQNYFCQFFTFFSYLASFCSVWFVVAFTVERFIAVIYPLKRQTMCTVRRAKIV 178
            ..|.       ::.|...|...|.|.   ..|:|..|..|::|:|||.:||:..|:....|.:.|
Zfish    86 LEDFILGAPLPHSLNKAVQVLEFSSI---HTSIWITVPLTIDRYIAVCHPLRYHTVSYPARTRKV 147

  Fly   179 LFCLTLVGCL-HCLPYIVIAKPVFMPKLNTTICDLNSEYKEQLALFNYWDTIVVYAVPFTTIAVL 242
            :..: ..||| ..:||                               ||...:.:.:|
Zfish   148 ILAV-YAGCLISSVPY-------------------------------YWWPELWHGLP------- 173

  Fly   243 NTCTGCTVWKFATVRRTLTMHKMKPQTNSMPSNSSNSSGGASSAVASYRLSASLKRQKSTGTHPS 307
                                              ..|.||.||:                    :
Zfish   174 ----------------------------------GASPGGRSSS--------------------A 184

  Fly   308 GQHNVANRQTDDQEQQQQSQQHQIN-------NCQHHCEITQKPARRKVQNSSQLKVTKMLLIVS 365
            |||.:.............|....:|       .|:..|        .:::..|..|.|.:||.::
Zfish   185 GQHVLVWVHCATVYLLPCSVFFSLNAIIVRKLRCRRSC--------FRLRGYSTGKTTAILLAIT 241

  Fly   366 TVFVCLNLPSCLLRIEAYWETESARNQNSTI--ALQYIFHAFFITNFGINFVLYCVSGQNFRK-- 426
            :||..|..|..|:.:...:..:.|....:.:  .:..:.:...:.|.|:||.|||...:.||:
Zfish   242 SVFAVLWAPRTLMILYHLYTVQPAMPGPARLLHLVTDVANMLALLNTGVNFFLYCFISKRFRRMA 306

  Fly   427 -AVLSIFRR 434
             .||..|.|
Zfish   307 GTVLKAFFR 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNMaR	NP_001027122.2	7tm_4	73..>262	CDD:304433	46/197 (23%)
gpr139	NP_001352082.1	7tmA_GPR139	28..306	CDD:320585	82/384 (21%)
		TM helix 1	28..53	CDD:320585	9/25 (36%)
		TM helix 2	61..86	CDD:320585	11/26 (42%)
		TM helix 3	100..130	CDD:320585	11/32 (34%)
		TM helix 4	142..162	CDD:320585	5/20 (25%)
		TM helix 5	186..211	CDD:320585	4/24 (17%)
		TM helix 6	228..260	CDD:320585	10/31 (32%)
		TM helix 7	274..299	CDD:320585	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593673
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840