DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNMaR and Gpr142

DIOPT Version :9

Sequence 1:	NP_001027122.2	Gene:	CNMaR / 39127	FlyBaseID:	FBgn0053696	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_038943713.1	Gene:	Gpr142 / 501735	RGDID:	1559926	Length:	348	Species:	Rattus norvegicus

Alignment Length:	406	Identity:	75/406 - (18%)
Similarity:	122/406 - (30%)	Gaps:	138/406 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YIPVLCCTGSIGNILSVFVFFRTKLR-KLSSSFYLAALAVSDTCFLAGLFAQWLNFL-------- 120
            |..||...|...|:|:..|..|..:| |..|..||.||..||  .:..:...::.||
  Rat    52 YYSVLLSLGLPVNVLTTVVLARLAVRTKKPSYHYLLALTASD--IVTQVVIVFIGFLLQGAVLAR 114

  Fly   121 ---NVDIYNQNYFCQFFTFFSYLASFCSVWFVVAFTVERFIAVIYPLKRQTMCTVRRAKIVLFCL 182
               ...:...|       ...:.|:..|||..|.|||:|:.|:..||:.:...:..|....:..:
  Rat   115 QVPQAVVRTAN-------ILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAV 172

  Fly   183 TLVGCLHCLPYI-------VIAKPVFMPKLNTTICDLNSEYKEQLALFNYWDTIVVYAVPFTTIA 240
            ..|..|..:|:.       ....|..|.|                 |..:...::||.:|.....
  Rat   173 LSVTLLTGIPFYWWLDVWRDADPPSTMDK-----------------LLKWAHCLIVYFIPCNVFL 220

  Fly   241 VLNTCTGCTVWKFATVRRTLTMHKMKPQTNSMPSNSSNSSGGASSAVASYRLSASLKRQKSTGTH 305
            |.|:         |.:.|                                     |:::...|..
  Rat   221 VTNS---------AIILR-------------------------------------LRKRGQRGLQ 239

  Fly   306 PSGQHNVANRQTDDQEQQQQSQQHQINNCQHHCEITQKPARRKVQNSSQLKVTKMLLIVSTVFVC 370
            |                                              ...|.|.:||.|:::|..
  Rat   240 P----------------------------------------------WMSKSTAILLGVTSLFAL 258

  Fly   371 LNLPSCLLRIEAYWETESARNQNSTIALQYIFHAFFITNFGINFVLYCVSGQNFRKAVLSIFRRV 435
            |..|...:.:...:.....|:....:||. |.:...:.|..:||.|||...:.||..|..:.:.|
  Rat   259 LWAPRISVMLYHLYVAPVHRDWRVHLALD-IANMLAMLNTAVNFGLYCFISKTFRATVRQVIQDV 322

  Fly   436 SSAQREAGNTQVTVSE 451
            ..:.......:.||:|
  Rat   323 HMSCALKSQPKGTVTE 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNMaR	NP_001027122.2	7tm_4	73..>262	CDD:304433	44/207 (21%)
Gpr142	XP_038943713.1	7tm_GPCRs	47..315	CDD:421689	70/381 (18%)
		TM helix 1	48..74	CDD:410628	7/21 (33%)
		TM helix 2	82..107	CDD:410628	8/26 (31%)
		TM helix 3	121..151	CDD:410628	11/36 (31%)
		TM helix 4	163..183	CDD:410628	3/19 (16%)
		TM helix 5	200..225	CDD:410628	7/50 (14%)
		TM helix 6	240..272	CDD:410628	9/77 (12%)
		TM helix 7	283..308	CDD:410628	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421120at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920