DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNMaR and GPR139

DIOPT Version :9

Sequence 1:	NP_001027122.2	Gene:	CNMaR / 39127	FlyBaseID:	FBgn0053696	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001002911.1	Gene:	GPR139 / 124274	HGNCID:	19995	Length:	353	Species:	Homo sapiens

Alignment Length:	422	Identity:	85/422 - (20%)
Similarity:	150/422 - (35%)	Gaps:	119/422 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 FVHQYYIPVLCCTGSIGNILSVFVFFRTKLRKLSSSF-YLAALAVSDTCFLAGLFAQWLNFLNVD 123
            ||...|..:|.|.|...|||:|.:..:...|:..||: ||.|||.:|...|  .|..:::||..|
Human    27 FVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVL--FFIVFVDFLLED 89

  Fly   124 IYNQNYFCQ----FFTFFSYLASFCSVWFVVAFTVERFIAVIYPLKRQTMCTVRRAKIVLFCLTL 184
            ........|    ......:.:...|:|..|..|::|:|||.:|||..|:....|.:.|:..:.:
Human    90 FILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYI 154

  Fly   185 VGCLHCLPYIVIAKPVFMPKLNTTICDLNSEYKEQLALFNYWDTIVVYAVPFTTIAVLNTCTGCT 249
            ...|..:||      .:.|.:.|.  |..|.....:.::.:..|  ||.||.:...:||
Human   155 TCFLTSIPY------YWWPNIWTE--DYISTSVHHVLIWIHCFT--VYLVPCSIFFILN------ 203

  Fly   250 VWKFATVRRTLTMHKMKPQTNSMPSNSSNSSGGASSAVASYRLSASLKRQKSTGTHPSGQHNVAN 314
                     ::.::|::.::|                   :||     |..|||
Human   204 ---------SIIVYKLRRKSN-------------------FRL-----RGYSTG----------- 224

  Fly   315 RQTDDQEQQQQSQQHQINNCQHHCEITQKPARRKVQNSSQLKVTKMLLIVSTVFVCLNLPSCLLR 379
                                                     |.|.:|..::::|..|..|..::.
Human   225 -----------------------------------------KTTAILFTITSIFATLWAPRIIMI 248

  Fly   380 IEAYWETESARNQNSTIA--LQYIFHAFFITNFGINFVLYCVSGQNFRKAVLSIFRRVSSAQREA 442
            :   :....|..||..:.  :..|.:...:.|..|||.|||...:.||....:..:.....|::.
Human   249 L---YHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQP 310

  Fly   443 ------GNTQVTVSEYCRNTGTSTRRRMMTQH 468
                  .|..:|.|.:.....:...:.::.|:
Human   311 VQFYTNHNFSITSSPWISPANSHCIKMLVYQY 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNMaR	NP_001027122.2	7tm_4	73..>262	CDD:304433	48/193 (25%)
GPR139	NP_001002911.1	7tmA_GPR139	27..296	CDD:320585	80/374 (21%)
		TM helix 1	29..53	CDD:320585	8/23 (35%)
		TM helix 2	63..85	CDD:320585	8/23 (35%)
		TM helix 3	102..124	CDD:320585	3/21 (14%)
		TM helix 4	147..163	CDD:320585	2/15 (13%)
		TM helix 5	181..204	CDD:320585	7/39 (18%)
		TM helix 6	227..249	CDD:320585	5/21 (24%)
		TM helix 7	264..289	CDD:320585	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840