DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG18180 and PROC

DIOPT Version :9

Sequence 1:NP_648341.1 Gene:CG18180 / 39125 FlyBaseID:FBgn0036024 Length:264 Species:Drosophila melanogaster
Sequence 2:XP_024308770.1 Gene:PROC / 5624 HGNCID:9451 Length:576 Species:Homo sapiens


Alignment Length:257 Identity:70/257 - (27%)
Similarity:113/257 - (43%) Gaps:47/257 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 RIVNGYPAPEGKAPYIVGLFIRTDGSNSGAVGAGTIIANDWILTAAHCL---------TGDYVEI 90
            |:::|.....|.:|:.|.|.   |.....|.|| .:|...|:||||||:         .|:| ::
Human   326 RLIDGKMTRRGDSPWQVVLL---DSKKKLACGA-VLIHPSWVLTAAHCMDESKKLLVRLGEY-DL 385

  Fly    91 HYGSNWGWNGAYRQTVRRDNFISHPDW-PSQGGRDIGLIRTPH-VDFNGLINKIPLP----SMNE 149
            .....|..:...::.     |: ||:: .|....||.|:.... ...:..|..|.||    :..|
Human   386 RRWEKWELDLDIKEV-----FV-HPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERE 444

  Fly   150 QNDRYQDTWCVACGWGGMDN------GNLADWLQCVDVQIISNSECEQAYGSVASTDMCTRH--A 206
            .|...|:|  :..|||...:      .|....|..:.:.::.::||.:...::.|.:|....  .
Human   445 LNQAGQET--LVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILG 507

  Fly   207 DGKSVCGGDSGGPLVT--HDNARLVGVITFASVSC---HDGPSGYTRVSDYLEW----IRDQ 259
            |.:..|.||||||:|.  |....|||::::.. .|   |: ...||:||.||:|    |||:
Human   508 DRQDACEGDSGGPMVASFHGTWFLVGLVSWGE-GCGLLHN-YGVYTKVSRYLDWIHGHIRDK 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18180NP_648341.1 Tryp_SPc 35..256 CDD:214473 67/252 (27%)
Tryp_SPc 36..259 CDD:238113 68/254 (27%)
PROCXP_024308770.1 GLA 117..168 CDD:214503
EGF_CA 182..213 CDD:238011
FXa_inhibition 255..290 CDD:317114
Tryp_SPc 328..563 CDD:238113 66/249 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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