Protein Alignment CG18180 and KLK1

DIOPT Version :10

• Sequence 1: NP_648341.1
• Gene: CG18180 / 39125
• FlyBaseID: FBgn0036024
• Length: 264
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 79/287 - (27%)
• Similarity: 126/287 - (43%)
• Gaps: 62/287 - (21%)

  Fly     3 LFLLTLSAALAL--VAASPTGLNRTTLLSQGAEGRIVNGYPAPEGKAPYIVGLFIRTDGSNSGAV 65
            ::.|.|..||:|  ..|:|.           .:.|||.|:...:...|:...|:     ..|...
Human     1 MWFLVLCLALSLGGTGAAPP-----------IQSRIVGGWECEQHSQPWQAALY-----HFSTFQ 49

  Fly    66 GAGTIIANDWILTAAHCLTGDY----------------VEIHYGSNW---GWNGAY--RQTVRRD 109
            ..|.::...|:||||||::.:|                ..:|...::   |:|.:.  ..|.:.|
Human    50 CGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQAD 114

  Fly   110 NFISHPDWPSQGGRDIGLIR--TPHVDFNGLINKIPLPSMNEQNDRYQDTWCVACGWGGM--DNG 170
            ...||         |:.|:|  .|.......:..:.||:...:    ..:.|:|.|||.:  :|.
Human   115 EDYSH---------DLMLLRLTEPADTITDAVKVVELPTEEPE----VGSTCLASGWGSIEPENF 166

  Fly   171 NLADWLQCVDVQIISNSECEQAY-GSVASTDMCTRHAD-GKSVCGGDSGGPLVTHDNARLVGVIT 233
            :..|.|||||::|:.|.||::|: ..|....:|..|.: ||..|.|||||||:.  :..|.||.:
Human   167 SFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMC--DGVLQGVTS 229

  Fly   234 FASVSC--HDGPSGYTRVSDYLEWIRD 258
            :..|.|  .:.||...||..|::||.|
Human   230 WGYVPCGTPNKPSVAVRVLSYVKWIED 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18180	NP_648341.1	Tryp_SPc	36..259	CDD:238113	71/252 (28%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	71/252 (28%)