DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18179 and PRSS54

DIOPT Version :9

Sequence 1:	NP_648340.1	Gene:	CG18179 / 39124	FlyBaseID:	FBgn0036023	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_001073961.1	Gene:	PRSS54 / 221191	HGNCID:	26336	Length:	395	Species:	Homo sapiens

Alignment Length:	297	Identity:	65/297 - (21%)
Similarity:	103/297 - (34%)	Gaps:	82/297 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLFLLTLSVALAVVAASPGFNRTSLLPQVTISEGAEGRIVNGYPAPEGKAPYIVGLLIRTDGSN 65
            |:..||.| :.|...:.|.|..:.|:.......||....:         :.|::|.|    ..|.
Human    13 MRGVLLVL-LGLLYSSTSCGVQKASVFYGPDPKEGLVSSM---------EFPWVVSL----QDSQ 63

  Fly    66 SAAVGAGTIIASDWILTAAHCLTT--DYVEIHYGSNWGWNGAFRQSVRRDNFISHPNWPAEG--- 125
            ...:..|.|::..|:|:.|..:..  |.|.|...||..           .:.|:|..:|...
Human    64 YTHLAFGCILSEFWVLSIASAIQNRKDIVVIVGISNMD-----------PSKIAHTEYPVNTIII 117

  Fly   126 ---------GRDIGLIRT-PSVGFTDLINKVALPSFSEESDRFVDT-----WCVACGWGGMD-NG 174
                     ..:|.|::| .::.|.:|:..:..      ..|.:.|     .|...||.... .|
Human   118 HEDFDNNSMSNNIALLKTDTAMHFGNLVQSICF------LGRMLHTPPVLQNCWVSGWNPTSATG 176

  Fly   175 NLADWLQCMDVQIISNSECEQSYGTVASTDMCT------------RRTDGKSSCGGDSGGPLVTH 227
            |      .|.:.::...       .|...|||.            .:.:.|::|.||.|.|::..
Human   177 N------HMTMSVLRKI-------FVKDLDMCPLYKLQKTECGSHTKEETKTACLGDPGSPMMCQ 228

  Fly   228 ----DNARLVGVITFGSVDCHSGPSGYTRVTDYLGWI 260
                |...|.||:.||...| .|...||:|.||..||
Human   229 LQQFDLWVLRGVLNFGGETC-PGLFLYTKVEDYSKWI 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18179	NP_648340.1	Tryp_SPc	39..260	CDD:214473	53/257 (21%)
CG18179	NP_648340.1	Tryp_SPc	40..263	CDD:238113	55/258 (21%)
PRSS54	NP_001073961.1	Tryp_SPc	52..264	CDD:214473	53/246 (22%)
		Tryp_SPc	52..264	CDD:238113	53/246 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910