Protein Alignment fry and TAO3

DIOPT Version :9

• Sequence 1: NP_001246701.1
• Gene: fry / 39122
• FlyBaseID: FBgn0016081
• Length: 3544
• Species: Drosophila melanogaster
• Sequence 2: NP_012137.3
• Gene: TAO3 / 854677
• SGDID: S000001391
• Length: 2376
• Species: Saccharomyces cerevisiae
• Alignment Length: 3288
• Identity: 586/3288 - (17%)
• Similarity: 1069/3288 - (32%)
• Gaps: 1268/3288 - (38%)

  Fly    73 GVGVVTPTKSPQRNAFQEDAYQANLAGGDSVDNIESAQLDGGNPSGGSPGQRHSINSAEYTSTPK 137
            |:|...|              ..|.|.|.|.:|..|..:|   |||  ......||.|...:.|
Yeast    14 GIGFTFP--------------PTNKAEGSSNNNQISIDID---PSG--QDVLEEINEAPLNTFP- 58

  Fly   138 TTRSGPNGSTTASGTTSPINYQLPG-DDYPYGIEYESQQLLYQQQQQQQ-----------QQQSQ 190
                     ...|.|.:|| ..:|. .|...|....:|.||.|||||..           ::||.
Yeast    59 ---------LHQSVTDAPI-IDIPSPTDMSEGTSLNNQLLLRQQQQQGTGEGQALPPTFVEEQSD 113

  Fly   191 QQ-------QQQQQQQQQQLPVGDVEQSSAVTYQSLPVSRQSYASPPALIIPQRQSLLPWGAHSR 248
            |.       :|:||:.|:..|.....:|.|..|  :...||..|:             .|.:
Yeast   114 QNKISMLLPEQKQQRMQESAPPDITAKSVAEDY--VTTLRQQMAT-------------DWKS--- 160

  Fly   249 SSIINVLPSYTQAEMHALAARVASVETSAPRPGEIVMRNLFSDFTAQAEKKIELVM--LESADKN 311
                                           |.|..:..||:.|...||.|:.:.:  |:.|:..
Yeast   161 -------------------------------PSEYALHILFTKFIRYAENKLNMCLQQLDMAEPP 194

  Fly   312 LSKLLQRGEDQQFDQLLSALGSVAEHCLPSLLHTLLAWHR----------RQLSDMEIKNDLKKP 366
            :.::|..|.|..||:::.:||.:|:.....::..::.|.:          .::..:..:.:.:|.
Yeast   195 IVEILGEGVDPSFDEIIKSLGHIAKKKPKPVIDAMMFWRKTKSEAANSASEEMEKLLKEYEFEKA 259

  Fly   367 APS--------------------------------------------------GSSSQAATNKPT 381
            .||                                                  .||:.:||:.|:
Yeast   260 HPSQAHFLMNRRLSRSSSNTTSKYKHNNNTNNLPGMKRHVSSSFNNKVPLIKASSSNNSATSSPS 324

  Fly   382 VDLDFQLQRREAAVE-----------------FIFCLALIEILKQLPYHPGHEDLVRSIENLAFK 429
            : .:.||:..|..:|                 :|.|..|.||:||...:. .|||...:|.:.|.
Yeast   325 I-ANSQLKSLENTIEVAKEEAFLADRKSLISIYILCRVLNEIVKQASSNE-EEDLSDKLEEIVFT 387

  Fly   430 HFKYKDGLQNNPNALNIHMIA----DLYAEVIGVLAQSRFASVRKRFMSELKELRG---KEVSPT 487
            ..|..|     |.:::..:|.    :.:||::|.:::.:|.||..||:::|:::..   .|:.|:
Yeast   388 QLKTTD-----PLSISTSLIKSSNWNSFAELLGSMSEKKFLSVSDRFIADLEKIPAYIPPELEPS 447

  Fly   488 TTQSIISLLMGMKFFRVKMVPIEEFEASFQFMHECGQYFLEVKDKDIKHALAGLFVEILVPVAAA 552
            |.    .|::||::.:::..|:|:||.|..||....::|.:.::..:..|.|.:..::|:|:|.:
Yeast   448 TH----LLILGMRYLKLRNYPLEKFEESADFMKSLSKFFAKTENFPVCLAYAEVTNQLLLPLAGS 508

  Fly   553 VKNEVNVPCVKNFVELLYVQTLDASTK-----SKHRLALFPLVTCLLCVSQKTFFLTNWHYFLAM 612
            :..|||.|   .:||.:  .||..:.|     ||:.::.|.|...:||.|....|...|...|..
Yeast   509 LTAEVNHP---TWVEAM--STLLNTAKRLQADSKYWVSGFKLTVSILCASPPDLFSKQWLSLLEA 568

  Fly   613 CLSNLKNRDAKMSRVALESLFRLLWVYMIRIKCESNSATHS---RLQSIVNSL----FPKGSKGV 670
            ..|.:|::......:....|.||:|||:.|.....|:.|.:   .||..:|:.    :..|..|:
Yeast   569 NASKVKSKSLNERIIFAVGLSRLVWVYLYRCPETLNNTTRTLTKLLQLYLNTRKKENWITGDFGL 633

  Fly   671 VPRDTPLNIFVKIIQFIAQERLDFAMREIVYDLL---CVGRSIKLILNPERMSIGLRAF--LVVA 730
            :   .||...:..|.|:   ..:|.|.:.:..|:   ..|.:::.| |.|::.:.:..:  |:|.
Yeast   634 L---NPLTDALISIGFL---HPNFLMEQALIPLIRQSFNGSNLENI-NYEKLILTINTYKGLLVT 691

  Fly   731 DSLQQKAGEPPMPRTVPVLPSGNTLRVKKTFNKMYVL-LTDDTARSIGMSTYFPH--VRRVFVDI 792
            .       |.|              |..:..|::|.| |.:.|...:..::...|  :...|..:
Yeast   692 K-------ERP--------------RFPEDDNRLYELNLNNITVNQVQEASSINHTEISDYFYKL 735

  Fly   793 LRALDVHYGRPLMMTNTQNQNKEP------------DEMLSGERKPRIDLFRTCVAAVP------ 839
            ...||...|..:.....|:|.:..            |...|..:...:.||.|.:.|:|
Yeast   736 FLLLDSSIGSEVWSPENQHQKQSSNAFSPFGFSFSNDNDSSKNKSLYVILFGTIIEAIPCCLSIS 800

  Fly   840 RLIPDTMTPHELVDMLSRLSVHMD--------EELRIL-THQSLTTLVIDFP----DWRQDVVHG 891
            |.||...|    :::|||.:||.:        ..||.| :.::..||:..|.    |:.:.....
Yeast   801 RTIPYKST----IEILSRNAVHSEVIISSSSQNALRALASKKNPYTLITWFAKYSFDFDEKTQSS 861

  Fly   892 YTQFLVRDVTDTYPQLLENCTRILFTFLNIWRC------ATNVNGNNTTSAPSGATNVVNTSQAK 950
            |....:..         :...|:|..::.:..|      ::|...|...:...|
Yeast   862 YNMSYLSS---------KEYNRLLILYVELLECWLEEFQSSNKEENKKETGLDG----------- 906

  Fly   951 MTTATTTTTVVQATVVQVTSAPAKDTASSQLSKQQHLNTASSAASSITTSSGMSSITQHTVLNMA 1015
                           :::....|:...|::..|.:..||
Yeast   907 ---------------IRLLPIDAEQEESNETEKLEWKNT-------------------------- 930

  Fly  1016 SDVGKKNEIPLATTLHFVEGFALVLLCNYRTYLRKLAALILKEVKNLMRALGIPETE-------- 1072
                       .|.:..|||..|..||::...:|:|...||:.:.....|: :.:||
Yeast   931 -----------VTVIEEVEGNGLFFLCSHDAKIRRLGIQILRIIFKFDEAM-MEKTEKLSNGHSR 983

  Fly  1073 ----------PPLIDVMDRCVPGIIEKCLPQLPQTEKTAILNANCIDLQWIAERSSGVWLAGLTD 1127
                      ..|||:::.|               ..|.::|.:...|       |.|.....:.
Yeast   984 SSSHFAADRGTRLIDLLNEC---------------NTTTLINPHKATL-------SAVEKTRFSR 1026

  Fly  1128 DNSKSSTSTL-NLSQSSSTPNASATAASSPQLPFDPWATCLFGLLERQNVLQQCPSAVAQAWPIC 1191
            .|||.....| .|::|....:|:....:.|:         |..|     |.:.||.|:|....|.
Yeast  1027 LNSKYKRGLLIKLAESEYGVDAALWQRAFPK---------LLAL-----VFKTCPMAMALCRSIV 1077

  Fly  1192 FTRLNALYSVIDPTPVSDNRASLLRSSAPTKKVPTESQKDSYLRLWRNQVACAMRLVPQIPSVAV 1256
            ..||..::.:|  ..|:::....|::..|          ::.:..|:..:..|
Yeast  1078 CIRLVQVHEII--LRVANDVDFKLKNVLP----------ETIVNQWKLYLIAA------------ 1118

  Fly  1257 RCASPDLSLSLQDQSDSRSLSDSLD---NIPSNVFGPEGIVTRFTLPLSYGRKEARQ------KR 1312
             |.               ||:.:.|   :||||:  |:           :|||:::|      ::
Yeast  1119 -CT---------------SLTSTFDQKLHIPSNI--PQ-----------HGRKKSQQIFTVQHQK 1154

  Fly  1313 LGSSPDSLNADRSDKSAMGSASPQALYKLVVPLLRCEVVDVRDAAVNALGLINHDALKDLMEELV 1377
            :             |||      ::::|:|:|||..:.:.:|||.:..|..:|.:..|..:|.:.
Yeast  1155 I-------------KSA------KSIFKMVLPLLNAKYIMIRDAIITGLSSMNINIFKAYVEAID 1200

  Fly  1378 VYIREAVDCKQENMRRRRRRDALRLQVVRVLEKIAENGTFGVSTCVLERDTMSLHPTFVL----- 1437
            |::   |..|:.:...:     :|:::..:|.         :.:..|:.| |..:..::|
Yeast  1201 VFL---VAWKEGSSNNQ-----IRVEMFHILT---------ILSPYLKSD-MIFNDEWILRKLSE 1247

  Fly  1438 YISGAMGYLTSETDKDNLSIREVKAHFCNFI---------RKMIKN-FPLEACATLLSRVLKRNL 1492
            ::.....:|..::.:.:...:.::::|...|         ..:|.. ||.:|         :.:.
Yeast  1248 FLQKTKQFLEKDSVQISYEYQSLRSYFAGLILSYYMAVREHPLIDELFPFQA---------RASC 1303

  Fly  1493 FNLFAAWCG-SFSKPLG---YTMQSDHT--------------LEEEKLQFSALQAMSALLCCGQI 1539
            ||....||| ...:|:.   |.:...:|              .::.:||...|:.| .:||...|
Yeast  1304 FNFLKEWCGYGEYEPISEERYAIMIKNTESGRDRTAITTGIEFQKNRLQMIVLETM-VVLCSDPI 1367

  Fly  1540 FNPSYLQDD-----------SIIYKWLDMLLTSKNEKIYQLARDTVVLLLESNPDIGQLLEWVID 1593
              ...|.||           ..:..|::.|..|.|..:..|....:..||:.|.:..:|...|..
Yeast  1368 --TQTLDDDLELPIVISFDTEDLLAWIEALFDSDNTTVKNLGVRALENLLDKNRENFKLFRDVAF 1430

  Fly  1594 RCYTSTPREADACFLALASIFSAKEYPCDHYTSVITVTLLMTGCPRVEVHATALQLLQILDKRFF 1658
            :|.:.....:.|..               :||::....|.:......|....:|.|        :
Yeast  1431 QCVSHHSHPSVAVL---------------YYTTLCKSVLKLDNLVLDEDELVSLGL--------Y 1472

  Fly  1659 GSVVGTLHSDSDKEDDKVGTLDVLL-------SSAYCR--------SQRFLSKQLAQ-------- 1700
            |.|       :||||.:...:|:|.       :|:|.:        |.:.:.|..|:
Yeast  1473 GLV-------ADKEDTRTFAVDLLSAVETKLHNSSYTKVFKERLANSSKTVYKSTAKEISSIFAE 1530

  Fly  1701 -LRPELTMSIFSEITHRFQSAREDVRALLLQCLLPWLQNMELVATSVPPATPLSYIMYFPDSGTR 1764
             |..:|.:.|||.:.........:::..||..::||:....|
Yeast  1531 LLSQDLCLRIFSSLVRILDLFPFEIKRDLLVLMVPWVNKFTL----------------------- 1572

  Fly  1765 GRREGTGSTEA--TEMILNNLFYITAKFSDAHPRDIEELWGTLCQ---FWPNNLKVILRYLV--I 1822
                  .|.|.  |.|:||||||||...:|:.|.::|:||.:|.:   |  .|:.|.|.|::  .
Yeast  1573 ------KSLEELDTFMVLNNLFYITIDLNDSLPNEVEQLWISLGKGNSF--QNIHVSLEYIINSS 1629

  Fly  1823 MSGMAPTELLPYAKRVALYLVRSCPD--RLLDELMAELQTVETLNCLIERTETPPFYRLTSMRKA 1885
            |:...|. .:.||:.:.|||. :.|.  .|||.|:..|:               |.|
Yeast  1630 MNHCNPL-FVQYARDIVLYLA-NIPGGIGLLDTLLNNLE---------------PKY-------- 1669

  Fly  1886 SSHSADGQAAGGINDSRIQDLAVEKGTIHTKRHSGEDPMKIGTCKSDSGIRAYTQAAAAAAAAAV 1950
                                      .:...:|:..:||
Yeast  1670 --------------------------MVPLAKHTFNEPM-------------------------- 1682

  Fly  1951 TPGSSGNRPPRGADKIRAASGPSILPRPEDILINDPELRQEENVELRGTSDAAPNGHPHPLPMPE 2015
                                                                  |.:.:
Yeast  1683 ------------------------------------------------------NNNKY------ 1687

  Fly  2016 YGGYFAPLTEFLPDV--SLPISG----FHRCNVAVMLLTDIVVDGIPGIDWTLHLPLMLHILFLG 2074
                     .||.::  .|..:|    |.:..::::.|.:::.:....:  ...:||:||:....
Yeast  1688 ---------SFLGNIWERLNYNGKRIIFSKAQLSIIFLVNLLTNLSESV--KAKIPLLLHMSICL 1741

  Fly  2075 LDHTRIIVREHCKQLCVNLLIVLAEHNDHLTVARILLNSETSKLDLGLTVPALPVIDNNFTELHQ 2139
            |||...::.|...::...|:..||
Yeast  1742 LDHYVPLIHESACKIASTLIFGLA----------------------------------------- 1765

  Fly  2140 QFDSYLLHVSPQAAAYALQHNLSSSTIIAAHHQNLSQTPQSQQQTGSQNGQTTTPPGLTATPAAL 2204
                                                                             
Yeast  1766 ----------------------------------------------------------------- 1765

  Fly  2205 QINPNNSENSEVPLIHPDEHAPPQPGPSMPIAHVIKSLLKFLAQDTCQPLWNYEDITAKVWAVKS 2269
               |::.::.|...:..::||                            ||:|:::..|  ..:|
Yeast  1766 ---PSHEKSEETVKLLRNKHA----------------------------LWSYDNLMKK--GARS 1797

  Fly  2270 AEQLSCFLKHMVKVFAD----SYPQARIAERWAQTALQLGLSCSSRHYAGRCLQIFRALNVPINS 2330
            .:.:...:::::.:|:|    .....|||.:||.|       ||.||.|.|..||||:|...::.
Yeast  1798 PKTMDLLIRNIISIFSDLDEFQVTWQRIALKWATT-------CSVRHIACRSFQIFRSLLTFLDQ 1855

  Fly  2331 RMLSDILSRLVETVAEQGEDMQGYVTELLLTLEAAVDSLDSDFRPLDVMKDIFKSTPNLNNKDGG 2395
            .||.|:|.||..|:::...|:||:..::|:||.|.:..||
Yeast  1856 EMLRDMLHRLSNTISDGNVDIQGFAMQILMTLNAIMAELD------------------------- 1895

  Fly  2396 PNSILPGKKSPSGMTPQSSNYSIPSHGRSTSYSVSYCGRKANNSPCDKQVELRNRSSGIDLERSV 2460
            |.:::                |.|
Yeast  1896 PTNLI----------------SFP----------------------------------------- 1903

  Fly  2461 VCKFGVGGGGAGSALSRSRSAQSLKMLGDTATQDDKMTILAQLFWLSVSLLESDYEHEFMLALRL 2525
                                                     ||||...:.|.|.:|.||:..|..
Yeast  1904 -----------------------------------------QLFWSITACLSSIHEQEFIEVLSC 1927

  Fly  2526 LTRVLHRLPLDRPDARDKVEKLQQQLKWTA-YPGVHALLLKGCTHSATYEPTITLLSQFAPLLTL 2589
            |::.:.::.||.||....:..:... .|.. :.|:..:::.|...:.:.|.|...|.:...|...
Yeast  1928 LSKFISKIDLDSPDTVQCLVAIFPS-NWEGRFDGLQQIVMTGLRSANSLEITWKFLDKLNLLKDS 1991

  Fly  2590 PVCDPTQSCAFPMNVIALLPYML--LHYEDANEICIRSAENIAQVSTELGAKLENLGTVMTLYSR 2652
            .:...|:| .....:||.||..|  :..:|...|.: :|:::.:::.  ..|..:|..::...::
Yeast  1992 RIIANTES-RLLFALIANLPRFLNAMDRKDFTGIQV-AADSLIELAN--AYKQPSLSRLIDSLAK 2052

  Fly  2653 KTF-CKESFQWTKCVVKYLHDTY-AHMGLHMVAFLIEVLEKGPQQVQVPVLNVIHCMLHYVDLSA 2715
            ..| .|:.|.  ..||.::...| .......:.||:.:|......::|..|.::..:...:||..
Yeast  2053 NKFRSKKDFM--SQVVSFISRNYFPSYSAQTLVFLLGLLFNKIGWIRVQTLEILKYVFPLIDLRR 2115

  Fly  2716 PQAQSINADLLRAIGKYLDTAYWKDSLKILKLIVTRSSSLQVVPPSDGSSAGLSFSFYGAYPDSD 2780
            |:...:.|||:..:.:.|.|.|...:|::          |..||...||..           |.|
Yeast  2116 PEFIGVGADLISPLLRLLFTEYEAKALEV----------LDCVPNVSGSKM-----------DKD 2159

  Fly  2781 MFCKKELAGRTMEFTFDVSQTPLIGRRILLKTEEPVAGGAVSTTGSSSLNSTLTNATTVTVAPSA 2845
            :.                        ||.:..::...|               .||||
Yeast  2160 VL------------------------RITMGNKDVKDG---------------DNATT------- 2178

  Fly  2846 AQQQTNVQMQQQRANTNVAALAAAAAAQHQQQQHAIGAGSSVVGTPNSPRRSASLSPADTVPLSG 2910
                                                    ::.|.|..               ||
Yeast  2179 ----------------------------------------TLFGLPED---------------SG 2188

  Fly  2911 WK--RPWMSQCRVRECLVNLLTTCGQRVGLPKSPSSLSTSLLTGSIATRQSVIFSQSSDLMERQS 2973
            |.  .|.|:....|..:..:..|||                 ||    :...:.:..||.|:...
Yeast  2189 WSVPMPTMTAATTRHNVHAVFMTCG-----------------TG----KSDEVSAHGSDDMDAVI 2232

  Fly  2974 SAASSTEETSGPQGDLSSGSRRDDGQPDFTVFKDFDF--LEYEDSIA-GESTD---NFNWGV--R 3030
            ...:        .||...|  |.|...:|....|:|.  ::..|||: .|..|   :..|..  .
Yeast  2233 EFHA--------DGDYELG--RMDTIVEFHADGDYDLGRMDTNDSISVAEEKDASLSHMWAELDN 2287

  Fly  3031 RHQLFEGDEDRLNCGSGIGGSIKGGHSSAFEDSFSDKT 3068
            ....|..|.:..|..|.:|..|..|.|.:.|.:.:|:|
Yeast  2288 LDSFFTKDTNVPNISSKMGMGIPHGRSDSIETTRTDQT 2325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fry	NP_001246701.1	MOR2-PAG1_N	389..923	CDD:290922	135/608 (22%)
		MOR2-PAG1_mid	1326..2098	CDD:290928	147/854 (17%)
		MOR2-PAG1_C	2501..2753	CDD:290925	55/256 (21%)
TAO3	NP_012137.3	MOR2-PAG1_N	348..887	CDD:404991	134/594 (23%)
		MOR2-PAG1_mid	936..1849	CDD:372971	235/1406 (17%)
		MOR2-PAG1_C	1903..2153	CDD:404994	59/348 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346459
Domainoid	1	1.000	52	1.000	Domainoid score	I2852
eggNOG	1	0.900	-	-		E1_KOG1825
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I403
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55726
OrthoFinder	1	1.000	-	-		FOG0001786
OrthoInspector	1	1.000	-	-		oto99212
orthoMCL	1	0.900	-	-		OOG6_102307
Panther	1	1.100	-	-	LDO	PTHR12295
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3991
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.920