DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fry and frya

DIOPT Version :10

Sequence 1:NP_001246701.1 Gene:fry / 39122 FlyBaseID:FBgn0016081 Length:3544 Species:Drosophila melanogaster
Sequence 2:XP_021322132.1 Gene:frya / 566822 ZFINID:ZDB-GENE-060510-4 Length:3060 Species:Danio rerio


Alignment Length:3485 Identity:1221/3485 - (35%)
Similarity:1784/3485 - (51%) Gaps:711/3485 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   248 RSSIINVLPSYT----------QAEMHALAARVASVETSAPRPGEIVMRNLFSDFTAQAEKKIEL 302
            |:||::..|.||          |.|....|....||:..: ||||.|:::||::||..:|:||.:
Zfish    51 RASILSSSPGYTKPPVPPVCCSQGEKGPPAMMPISVDPES-RPGEYVLKSLFANFTTISERKIRI 114

  Fly   303 VMLESADKNLSKLLQRGEDQQFDQLLSALGSVAEHCLPSLLHTLLAWHRRQLSDMEIKNDLKKPA 367
            ||.|..:|.|.|.||||||.|||||:|.:.|:||:||||:|.||..|::|| :.::.::...:|.
Zfish   115 VMAEPLEKPLVKSLQRGEDLQFDQLISTMSSLAEYCLPSILRTLFDWYKRQ-NGVDDESHEYRPR 178

  Fly   368 PSGSSSQAATNKPTVDLDFQLQRREAAVEFIFCLALIEILKQLPYHPGHEDLVRSIENLAFKHFK 432
            .:..|......|     |:.|:||:.|::|||.|.|||:|||:|.||..:.||:.:.:|||||||
Zfish   179 SNTKSKNDEQQK-----DYLLERRDLAIDFIFSLVLIEVLKQMPLHPVVDGLVQEVIHLAFKHFK 238

  Fly   433 YKDGLQNNPNALNIHMIADLYAEVIGVLAQSRFASVRKRFMSELKELRGKEVSPTTTQSIISLLM 497
            ||:| .:.||..|:|::|||||||||||:|::|.:|:|||.|||||||.||.||...||.|||:|
Zfish   239 YKEG-YHGPNTANMHIVADLYAEVIGVLSQAKFPAVKKRFTSELKELRQKEQSPYVVQSTISLIM 302

  Fly   498 GMKFFRVKMVPIEEFEASFQFMHECGQYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCV 562
            |:|||||||.|:||||||||||.||.||||||||||||||||||||||||||||||||||||||:
Zfish   303 GVKFFRVKMYPVEEFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCL 367

  Fly   563 KNFVELLYVQTLDASTKSKHRLALFPLVTCLLCVSQKTFFLTNWHYFLAMCLSNLKNRDAKMSRV 627
            :||||.||..|||.|::.||.|||:|:||||||||||.|||..||.||..||||||::|.||:||
Zfish   368 RNFVESLYDTTLDLSSRKKHSLALYPMVTCLLCVSQKQFFLNRWHVFLNNCLSNLKSKDPKMARV 432

  Fly   628 ALESLFRLLWVYMIRIKCESNSATHSRLQSIVNSLFPKGSKGVVPRDTPLNIFVKIIQFIAQERL 692
            |||||:|||||||||||||||:||..||.|||.:||||||:.|||:|.|||||||||||||||||
Zfish   433 ALESLYRLLWVYMIRIKCESNTATQGRLNSIVTNLFPKGSRSVVPKDMPLNIFVKIIQFIAQERL 497

  Fly   693 DFAMREIVYDLLCVGRSIKLI-LNPERMSIGLRAFLVVADSLQQKAGEPPMPRTVPVLPSGNTLR 756
            ||||:|:::|||.||:..|.. ||||||:||||||||:||.||||.||||||.|...||||||||
Zfish   498 DFAMKEVIFDLLFVGKPAKAFSLNPERMNIGLRAFLVIADKLQQKDGEPPMPNTGATLPSGNTLR 562

  Fly   757 VKKTFNKMYVLLTDDTARSIGMSTYFPHVRRVFVDILRALDVHYGRPLMMTNTQNQNKEPDEMLS 821
            |||||  :...|::|.|:.||||.|:||||:...:|||.||...||.:|::|.|..||||::|::
Zfish   563 VKKTF--LSKPLSEDEAKVIGMSLYYPHVRKALDNILRHLDKEVGRCMMLSNAQMLNKEPEDMIT 625

  Fly   822 GERKPRIDLFRTCVAAVPRLIPDTMTPHELVDMLSRLSVHMDEELRILTHQSLTTLVIDFPDWRQ 886
            |||||:|||||||:||:||::||.|:..||:|:|:||::|||:|||::...||.:|::||.|||:
Zfish   626 GERKPKIDLFRTCMAAIPRILPDGMSKSELIDLLARLTIHMDDELRLIAQNSLQSLLVDFSDWRE 690

  Fly   887 DVVHGYTQFLVRDVTDTYPQLLENCTRILFTFLNIWRCATNVNGNNTTSAPSGATNVVNTSQAKM 951
            :|:.|:..||:|:|.||:..||::..::|...|..|:.|.    .:|..:|.             
Zfish   691 EVLLGFCSFLLREVQDTHQTLLDSSLKLLLQLLTQWKLAL----LSTNKSPD------------- 738

  Fly   952 TTATTTTTVVQATVVQVTSA---PAKDTASSQLSKQQHLNTASSAASSITTSSGMSSITQHTVLN 1013
                 |:.:..|.::|.:|.   ||:.|:.|                                  
Zfish   739 -----TSKICSAELLQSSSGSRLPAEWTSHS---------------------------------- 764

  Fly  1014 MASDVGKKNEIPLATTLHFVEGFALVLLCNYRTYLRKLAALILKEVKNLMRALG-IPETEPPLID 1077
                          |.||.|||.||||||:.:|..|:||..||:||:.:...:| ..|.|.|:||
Zfish   765 --------------TVLHAVEGLALVLLCSCQTGTRRLAVSILREVRQIFIIIGQTEEDERPMID 815

  Fly  1078 VMDRCVPGIIEKCLPQLPQTEKTAILNANCIDLQWIAERSSGVWLAGLTDD--NSKSSTSTLNLS 1140
            |:|:..|.::|. ...:...:..::......||||:.|     |...|...  :.:|.:....|:
Zfish   816 VLDQLSPMVLES-FAHVAVADSASLPAGQHADLQWLVE-----WNGSLVGSHYDVRSPSRVWILA 874

  Fly  1141 QSSSTPNASATAASSPQLPFDPWATCLFGLLERQNVLQQCPSAVAQAWPICFTRLNALYSVIDPT 1205
            ||..                :|||.|||.||.::.:.:.||:|::.|||..||||..|..:::|:
Zfish   875 QSLK----------------EPWALCLFSLLRQEYLPKHCPTALSYAWPYAFTRLQLLMPLLEPS 923

  Fly  1206 -PVSDNRASLLRSSAPTKKVPTESQKDSYLRLWRNQ-VACAMRLVPQIPSVA-VRCASPDLSLSL 1267
             ||:            .||..:....|:|:.||||. :.|.....|.|.|.. :|.::|:     
Zfish   924 NPVN------------AKKTSSAGSADTYVSLWRNYLILCFGVAKPSIMSPGHLRASTPE----- 971

  Fly  1268 QDQSDSRSLSDSLDNIPSNVFGPEGIVTRFTLPLSYGRKEARQKRLGSSPDSLNADRSDKSAMGS 1332
                                     |:|                   .||||.::  .|...:|:
Zfish   972 -------------------------IIT-------------------PSPDSNSS--YDNKILGT 990

  Fly  1333 ASPQALYKLVVPLLRCEVVDVRDAAVNALGLINHDALKDLMEELVVYIREAVDCKQENMRRRRRR 1397
            .|...|.|.:|||:|.|.:::.::.|...|..|....::|:|||...::||::.:.||.:||.||
Zfish   991 PSVAWLLKQLVPLMRSESIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERR 1055

  Fly  1398 DALRLQVVRVLEKIAENGTFGVST-CVLERDTMSLHPTFVLYISGAMGYLTSETDKDNLSIREVK 1461
            |.||||::|:.|.:|:.|....|| ..|||||::|...|:.|:......|.:|:|||...:::::
Zfish  1056 DLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAESDKDMEILKDIR 1120

  Fly  1462 AHFCNFIRKMIKNFPLEACATLL-SRVLKRNLFNLFAAWCGSFS---KPLGYTMQSDHTLEEEKL 1522
            |||...:..:|::.|:.....|. .:.|:.:||.||:.|.|.||   .||  ...||...:..:.
Zfish  1121 AHFSAMVANLIQSVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPL--DRYSDRNHQITRY 1183

  Fly  1523 QFSALQAMSALLCCGQIFNPSYLQDDSIIYKWLDMLLTSKNEKIYQLARDTVVLLLESNPDIGQL 1587
            |:.||:|||::||||.:|:...|..|..:|||||.:|..::.:::||..:.||||||.|||...|
Zfish  1184 QYCALKAMSSVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVVLLLELNPDQMNL 1248

  Fly  1588 LEWVIDRCYTSTPREADACFLALASIFSAKEYPCDHYTSVITVTLLMTGCPRVEVHATALQLLQI 1652
            ..|.:|||||.:.:.|..||.|:|::..::.|..|..| ::.:.|........|::..|:||:||
Zfish  1249 FNWAVDRCYTGSCQLASGCFKAIATVCGSRNYSSDIVT-LLNLVLFKASDTNREIYEIAMQLMQI 1312

  Fly  1653 LD-------KRFF----GSVVGTLHSDSDKEDDKVGTLDVLLSSAYCRSQRFLSKQLAQLRPELT 1706
            |:       ||..    |:::...|..              |...|..|...||||||::.||||
Zfish  1313 LEAKLSVYSKRIVEQKSGAILYGTHRP--------------LPPLYSLSVTQLSKQLARMYPELT 1363

  Fly  1707 MSIFSEITHRFQSAREDVRALLLQCLLPWLQNMELV------ATSVPPATPLSYIMYFPDSGTRG 1765
            :.:|||::.||.:...:.|.::|..|||||.|:|||      ..|.|.:...:...|..:|.:..
Zfish  1364 LPLFSEVSQRFPTTHPNGRQVMLAYLLPWLSNIELVDGGLLSTVSGPSSCVDNRKGYTHNSSSPH 1428

  Fly  1766 RREGT--GSTEATEMILNNLFYITAKFSDAHP-RDIEELWGTLC--QFWPNNLKVILRYLVIMSG 1825
            ...||  ||.:|:.::||||.::|||:.|..| .::|..|..|.  :.|.|||:.:|::|:.:.|
Zfish  1429 LLRGTGWGSLQASSLVLNNLMFMTAKYGDDVPGAEMENAWNALVSNERWTNNLRTVLQFLISLCG 1493

  Fly  1826 M-APTELLPYAKRVALYLVRSCPDRLLDELMAELQTVETLNCLIERTETPPFYRLTSMRKASSHS 1889
            : :.|.|||:.|:|.:||.|:...:.::||:.|||..:.:|.::...:.|||||.          
Zfish  1494 VSSDTSLLPHIKKVVIYLCRNNTMQTMEELLYELQQTDPVNPVVVHCDNPPFYRF---------- 1548

  Fly  1890 ADGQAAGGINDSRIQDLAVEKGTIHTKRHSGEDPMKIGTCKSDSGIRAYTQAAAAAAAAAVTPGS 1954
                                                                   :|.:.:...|
Zfish  1549 -------------------------------------------------------SATSKIVTTS 1558

  Fly  1955 SGNRPPRGA-------DKIRAASGPSILPRPEDILINDPELRQEENVELRGTSDAA--------- 2003
            ||  ||..:       :.|..|....|....:|.|.|  .||....:|.|.:|.:.         
Zfish  1559 SG--PPSSSKTLVCCQENIPDADDSPITKECDDRLSN--ILRAHNRLESRYSSSSGGSYDEEKSE 1619

  Fly  2004 -------------PNGHPHPLPMPEYGGYFAPLTEFLPDVSLPISGFHRCNVAVMLLTDIVVDGI 2055
                         ....|.|||||..||.:|||.::||:...|....||.|:|||.:|::|||..
Zfish  1620 PIPPYAMWLMSVLETNQPLPLPMPVNGGCWAPLVDYLPETVTPRGPLHRSNIAVMFMTELVVDHS 1684

  Fly  2056 PGIDWTLHLPLMLHILFLGLDHTRIIVREHCKQLCVNLLIVLAEHNDHLTVARILLNSETSKLDL 2120
            ...||.|||||:||..|||:||.|..|.||||:|.::|||.|:.:|:...:|.:|||:..:..:.
Zfish  1685 VKEDWALHLPLLLHACFLGMDHFRPEVFEHCKRLLLHLLITLSCNNNFSLIASVLLNTRDANSNK 1749

  Fly  2121 GLTVPALPVIDNNFTELHQQFDSYLLHV----SPQAAAYALQHNLSSSTIIAAHHQNLSQTPQSQ 2181
            .||          |...:|. |.|...|    :.||:... ...||||               |.
Zfish  1750 SLT----------FKPFYQP-DFYTGGVDFLRNGQASPVP-DSGLSSS---------------ST 1787

  Fly  2182 QQTGSQNGQTTTPPGLTATPAALQINPNNSENSEVPLIHPDEHAPPQPGPSMPIAHVIKSLLKFL 2246
            ..:.|..|.::..|.||      |....|.|:|    ...||.:              ..|::||
Zfish  1788 SSSLSLGGSSSNLPHLT------QEEMENMESS----TEDDEKS--------------SKLIEFL 1828

  Fly  2247 AQDTCQPLWNYEDITAKVWAVKSAEQLSCFLKHMVKVFADSYPQARIAERWAQTALQLGLSCSSR 2311
            ......|||::||||.|....||.|||:.||:|:|.||.:|....|:.::.::.|||:.|..|||
Zfish  1829 TTRPFGPLWSHEDITPKNPQSKSTEQLTNFLRHVVSVFKESKSDIRLEQQLSEVALQMALCSSSR 1893

  Fly  2312 HYAGRCLQIFRALNVPINSRMLSDILSRLVETVAEQGEDMQGYVTELLLTLEAAVDSLDSDFRPL 2376
            |||||..|:||||..|:::..:||:||||||.|.|.||::||||.|||||||:.||:|....:..
Zfish  1894 HYAGRSFQVFRALRQPLSALAVSDLLSRLVEVVGEHGEEVQGYVMELLLTLESVVDNLAECLKNN 1958

  Fly  2377 DVMKDIFKSTPN--------LNNKDGGPNSILPGKKSPSGMTPQSSNYSIPSHGRSTSYSVSYCG 2433
            |....:..|:|:        ||.|......::||..:.|.......:||:|              
Zfish  1959 DFFVILRASSPDLPSSGKLTLNRKSTSQLELIPGSATASERIRHQRSYSVP-------------- 2009

  Fly  2434 RKANNSPCDKQVELRNRSSGIDLERSVVCKFGVGGGGAGSALSRSRSAQS----LKMLGDTATQD 2494
                     |:.....|||  |:.||             :.|.|....||    |:.|..::::|
Zfish  2010 ---------KRFGEAERSS--DVPRS-------------ATLDRIHHHQSNISKLRSLSSSSSRD 2050

  Fly  2495 DKMT-----------ILAQLFWLSVSLLESDYEHEFMLALRLLTRVLHRLPLDRPDARDKVEKLQ 2548
            :.::           :||.:||..|||:|||:|.|:.::||||.::|..:.||:.:.::|:||:|
Zfish  2051 NVVSTDPTNANHPHNLLATIFWAVVSLMESDFEFEYQMSLRLLGKLLGHISLDKQEYKEKLEKIQ 2115

  Fly  2549 QQLKWTAYPGVHALLLKGCTHSATYEPTITLLSQFAPLLTLPVCDPTQSCAFPMNVIALLPYMLL 2613
            .||||..:.|:..|||||.|.:.|.|.|:.|.||..|:..|||.|.:|:..||:||:.|:|:::|
Zfish  2116 LQLKWKDFTGLQKLLLKGFTSANTTELTLELFSQLTPVSRLPVVDTSQAIGFPLNVLCLIPHLVL 2180

  Fly  2614 HYEDANEICIRSAENIAQVS-TELGAKLENLGTVMTLYSRKTFCKESFQWTKCVVKYLHDTYAHM 2677
            |::..::.|...||.|:|:. .|..:||.||..|||||...::.::.|.|...|.:|||:.::..
Zfish  2181 HFDSPSQFCKDVAERISQICLEEKNSKLSNLAHVMTLYKTHSYTRDCFSWVNVVCRYLHEAFSDS 2245

  Fly  2678 GLHMVAFLIEVLEKGPQQVQVPVLNVIHCMLHYVDLSAPQAQSINADLLRAIGKYLDTAYWKDSL 2742
            .|.||.::.|:||||...:|..:|.:|:.:|.::|||..||:..|.::|..|.|::.|.:||::|
Zfish  2246 TLSMVTYMTELLEKGLPSMQQTLLQIIYSLLSHMDLSGIQAKLFNMEVLTTIEKFVQTTHWKEAL 2310

  Fly  2743 KILKLIVTRSSSLQVVPPSDGSSAGLSFSFYGAYPDSDMFCKKELAGRTMEFTFDVSQTPLIGRR 2807
            .||||:|:||:||  |.||...|...|......:...    .|.|.|:|::|.||:|:||:||||
Zfish  2311 NILKLVVSRSASL--VSPSSPQSNSSSVDVRRVWDTP----SKALPGKTLDFHFDISETPVIGRR 2369

  Fly  2808 ILLKTEEPVAGGAVSTTGSSSLNSTLTNATTVTVAPSAAQQQTNVQMQQQRANTNVAALAAAAAA 2872
            .    :|  ..|:....|.:....|:|.:|:.|   |:...|:|                     
Zfish  2370 Y----DE--LHGSPRQDGKNQGVVTVTRSTSST---SSGSYQSN--------------------- 2404

  Fly  2873 QHQQQQHAIGAGSSVVGTPNSPRRSASLSPADTVPLSGWKRPWMSQCRVRECLVNLLTTCGQRVG 2937
                  |.:                        ||:| ||||..||.|.||.|||:||.|||.||
Zfish  2405 ------HVL------------------------VPVS-WKRPQSSQKRTREKLVNVLTLCGQEVG 2438

  Fly  2938 LPKSPSSLSTSLLTGSIATRQSVIFSQSS--DLMERQSSAASSTEETSGPQGDLSSGSRRDD--G 2998
            |.|:|                |||||...  :|:|.|.|..||.:.|...:       ..||  .
Zfish  2439 LTKNP----------------SVIFSSCGELELIEHQPSLVSSEDGTRDTE-------NMDDTTS 2480

  Fly  2999 QPDFTVFKDFDFL--EYEDSIAGESTDNFNWGVRRHQLFEGDEDR---LNCGSGIGGSI------ 3052
            :..|.||:|||||  |.||. .||:.|:||||.||..:...|:..   |...|.:.||.      
Zfish  2481 EQQFRVFRDFDFLDVELEDG-EGETVDSFNWGARRRSIDSLDQTEAQPLEEDSQLSGSSPSLCPI 2544

  Fly  3053 ---KGGHSS----------------------------------AFEDSFSDKTPI---------- 3070
               ....||                                  :|:::.:|:.|:          
Zfish  2545 IHDDSDESSEEESLTASQILSASQLNVSLSPTEDLNPMDSPPVSFDNTQADQIPLSTSTPSFEIP 2609

  Fly  3071 LSKRKRQIADDSSDEE-----------AESESP----------LDEDHR-QSFLKSGYSAVPP-- 3111
            |.:.....|:||::||           ...|||          |:...| ::|.....|.||.  
Zfish  2610 LPEGSNHRAEDSAEEEEGIVNENDISLCICESPPAFSCSDILTLETPQREENFFTDEMSCVPSGF 2674

  Fly  3112 ----TSLSLRERRRRNSVSRSDTSGSSAGDLGDLTPCNASPHLPGII-RFSAAIHDEAEENWRRQ 3171
                :|::..|..:...:..|.:|..            .||....|: .|...:.|:|||.||..
Zfish  2675 GEQFSSVAQAEEEKEELLLESRSSPP------------PSPFFSAILAAFQPTMCDDAEEAWRSH 2727

  Fly  3172 VQALLVNQPSAHTSELLQQLYRLIKELTFKTVNISKEAKKFFTGIGSQ-LGNRISLFTDLLSSRA 3235
            :..|:.:...:......|....|.:.:..|...::.:|..:. |.|.: :|.:....:.:|:|.:
Zfish  2728 LNQLVADSDGSCAVYTFQVFSSLFQNIQSKFCTLTCDAAGYL-GDGLRGIGAKFLRSSQMLTSCS 2791

  Fly  3236 DPPQVWCSELQATSPKLFETLRFNVLEVQEHLETFFDRKDQVLECLDAVKTSCKLSLFNEADVAA 3300
            :.|.::.......|..|.|.::|:|||:||:|||:.::|:.|:..|    .:||.|         
Zfish  2792 ECPTLFVDADTIVSYGLLEKMKFSVLELQEYLETYNNKKEAVISWL----CNCKAS--------- 2843

  Fly  3301 SGLELPSTSSIVYMPFDPASTE-------VVLDLGRSLYKLMFQLLLLIESNHKISSNV--VNHF 3356
                .|..|....:.:.||.||       ..|:|.:.||||.||||||.:|..|:...|  :|..
Zfish  2844 ----FPKCSEDGVITYQPAETEEKQMEYLAQLELCQRLYKLHFQLLLLFQSYCKLIGQVHTINSV 2904

  Fly  3357 RMNEDM-HDISDLYALVRDALVRYISEAELDCLESSTSTEGEHTPTPSPGLPMTPEEFEAVL--T 3418
            ...::| .::|||.:.:|.|......|...|..:||..:          ....:....:|:|  .
Zfish  2905 PELQNMSRELSDLRSNLRAAAASVAEENTGDRRDSSAES----------SFSSSEAAVQAILESL 2959

  Fly  3419 EHIDLQRWPSAIAHVRQYRRISTLNASGYQNVTIFSYNSADNRQKWDEISVILNAY-AHGIMKDR 3482
            ::.||.|   ||.::|:.|::...:..|         :|::|     ||..:||.| .|..:...
Zfish  2960 KNCDLSR---AIRYIRECRKMWPSDIFG---------SSSEN-----EIQTLLNIYFRHQTLGQT 3007

  Fly  3483 TAEAFIVSKSDSEVFEIYAILSENLYQVSSALTNMEISMK 3522
            ...|.:.||.|             |.::.:.||.:...::
Zfish  3008 GTFALVGSKQD-------------LSEICNRLTELNCEIR 3034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fryNP_001246701.1 MOR2-PAG1_N 389..922 CDD:464107 352/533 (66%)
MOR2-PAG1_mid 1326..2330 CDD:433790 340/1064 (32%)
MOR2-PAG1_C 2501..2753 CDD:464109 105/252 (42%)
Fry_C 2785..3439 CDD:466072 193/757 (25%)
fryaXP_021322132.1 MOR2-PAG1_N 195..701 CDD:464107 343/508 (68%)
MOR2-PAG1_mid 770..1919 CDD:433790 422/1370 (31%)
MOR2-PAG1_C 2068..2321 CDD:464109 105/252 (42%)
Fry_C 2345..3060 CDD:466072 209/849 (25%)

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