|
Fly 172 ESQQLLYQQQQQQQQQQSQQQQQQQQQQQQQLPVGD-VEQSSAVTYQSL-------PVSRQS--- 225
:...|..:.:.:....|::.:..::.....:||:|: |:.......::| |..|.|
Mouse 4 DDSNLYSRTKNKLNSSQNEFKSLRRSSLPLELPIGNHVKGKLQRNIKNLEPFHLRRPKKRPSIFP 68
Fly 226 -------YASPPALIIPQRQSLLPWGAHSRSSIINVLPSYTQAEMHALAARVASVETSAPRPGEI 283
|..|| :|... |.|.......:|| .:|:..: :|||.
Mouse 69 ASPVGNGYIKPP---VPPAS-----GTHREKGPPAMLP--------------INVDPDS-KPGEY 110
Fly 284 VMRNLFSDFTAQAEKKIELVMLESADKNLSKLLQRGEDQQFDQLLSALGSVAEHCLPSLLHTLLA 348
|:::||.:||.|||:||.::|.|..:|.|:|.||||||.||||::|::.|::|:||||:|.||..
Mouse 111 VLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFD 175
Fly 349 WHRRQLSDMEIKNDLKKPAPSGSSSQAATNKPTVDLDFQLQRREAAVEFIFCLALIEILKQLPYH 413
|::|| :.:|.::...:|..|..|......: |:.::||:.|::|||.|.|||:|||:|.|
Mouse 176 WYKRQ-NGIEDESHEYRPRTSNKSKSDEQQR-----DYLMERRDLAIDFIFSLVLIEVLKQIPLH 234
Fly 414 PGHEDLVRSIENLAFKHFKYKDGLQNNPNALNIHMIADLYAEVIGVLAQSRFASVRKRFMSELKE 478
|..:.|:..|.||||||||||:|.. .||..|:|::|||||||||||||::|.:|:|:||:||||
Mouse 235 PVIDSLIHDIINLAFKHFKYKEGYL-GPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKE 298
Fly 479 LRGKEVSPTTTQSIISLLMGMKFFRVKMVPIEEFEASFQFMHECGQYFLEVKDKDIKHALAGLFV 543
||.||.||...||||||:|||||||:||.|:|:||||.|||.||..|||||||||||||||||||
Mouse 299 LRHKEQSPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFV 363
Fly 544 EILVPVAAAVKNEVNVPCVKNFVELLYVQTLDASTKSKHRLALFPLVTCLLCVSQKTFFLTNWHY 608
||||||||||||||||||::||||.||..||:.|::.||.|||:||||||||||||..||..||.
Mouse 364 EILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHV 428
Fly 609 FLAMCLSNLKNRDAKMSRVALESLFRLLWVYMIRIKCESNSATHSRLQSIVNSLFPKGSKGVVPR 673
||..|||||||:|.||:|||||||:|||||||||||||||:||.|||.:|..:||||||:|||||
Mouse 429 FLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITITTTLFPKGSRGVVPR 493
Fly 674 DTPLNIFVKIIQFIAQERLDFAMREIVYDLLCVGRSIKLI-LNPERMSIGLRAFLVVADSLQQKA 737
|.|||||||||||||||||||||:||::|.||||:..|.. ||||||:||||||||:|||||||.
Mouse 494 DMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKD 558
Fly 738 GEPPMPRTVPVLPSGNTLRVKKTFNKMYVLLTDDTARSIGMSTYFPHVRRVFVDILRALDVHYGR 802
||||||.|..|||||||||||||: :...||::.|:.||||.|:..||:...:|||.||...||
Mouse 559 GEPPMPVTGAVLPSGNTLRVKKTY--LSKTLTEEEAKMIGMSLYYSQVRKAVGNILRHLDKEVGR 621
Fly 803 PLMMTNTQNQNKEPDEMLSGERKPRIDLFRTCVAAVPRLIPDTMTPHELVDMLSRLSVHMDEELR 867
.:|:||.|..||||::|::|||||:||||||||||:|||:||.|:..||:|:|:|||:|||:|||
Mouse 622 CMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELR 686
Fly 868 ILTHQSLTTLVIDFPDWRQDVVHGYTQFLVRDVTDTYPQLLENCTRILFTFLNIWRCATNVNGNN 932
.:...||..|::||.|||:||:.|:|.||:|:|.|.:..||::..::|...|..|:......|.
Mouse 687 HIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGR- 750
Fly 933 TTSAPSGATNVVNTSQAKMTTATTTTTVVQATVVQVTSAPAKDTASSQLSKQQHLNTASSAASSI 997
|...|:.|
Mouse 751 ---------------------------------------------------------AYEQANKI 758
Fly 998 TTSSGMSSITQHTVLNMASDVGKKNEIPLATTLHFVEGFALVLLCNYRTYLRKLAALILKEVKNL 1062
..|..:.:.:.| .|.|:.| |..:.||.||||||||||:::...|||:.|||||::.|
Mouse 759 RNSELIPNGSSH---RMQSERG-----PHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRAL 815
Fly 1063 MRALGIPETEP-PLIDVMDRCVPGIIEKCL-------PQLPQTEKTAILNANCIDLQWIAERSSG 1119
..|||.||.:. |:|||||:....|:|..: ..||.|.. :||||:.|
Mouse 816 FLALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPPTHN--------VDLQWLVE---- 868
Fly 1120 VWLAGLTDD--NSKSSTSTLNLSQSSSTPNASATAASSPQLPFDPWATCLFGLLERQNVLQQCPS 1182
|.|.|.:. :.||.:.....:||.. |||..|||..|.::|:.:.||:
Mouse 869 -WNAVLVNSHYDVKSPSHVWIFAQSVK----------------DPWVLCLFSFLRQENLPKHCPT 916
Fly 1183 AVAQAWPICFTRLNALYSVIDP-TPVSDNRASLLRSSAPTKKVPTESQKDSYLRLWRNQ-VACAM 1245
|::.|||..||||.::..::|| :||: .||..|.|..|:|:.||||. :.|..
Mouse 917 ALSYAWPYAFTRLQSVMPLVDPNSPVN------------AKKTSTASSGDNYVTLWRNYLILCFG 969
Fly 1246 RLVPQIPSVA-VRCASPDLSLSLQDQSDSRSLSDSLDNIPSNVFGPEGIVTRFTLPLSYGRKEAR 1309
...|.|.|.. :|.::|::..:. |:|.| ||
Mouse 970 VAKPSIMSPGHLRASTPEIMATT----------------------PDGTV-------SY------ 999
Fly 1310 QKRLGSSPDSLNADRSDKSAMGSASPQALYKLVVPLLRCEVVDVRDAAVNALGLINHDALKDLME 1374
|..|:|:.|...|.|.:|||:|.|.:::.::.|...|..|....::|:|
Mouse 1000 ----------------DNKAIGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVE 1048
Fly 1375 ELVVYIREAVDCKQENMRRRRRRDALRLQVVRVLEKIAENGTFGVST-CVLERDTMSLHPTFVLY 1438
||...::||::.:.||.:||.|||.||||::|:.|.:|:.|....|| ..|||||::|...|:.|
Mouse 1049 ELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEY 1113
Fly 1439 ISGAMGYLTSETDKDNLSIREVKAHFCNFIRKMIKNFPLEACATLL-SRVLKRNLFNLFAAWCGS 1502
:......|.:|.||:...:::::|||...:..:|:..|:.....|. .:.|:.:||.||:.|.|.
Mouse 1114 VDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQCVPVHHRRFLFPQQSLRHHLFILFSQWAGP 1178
Fly 1503 FS---KPLGYTMQSDHTLEEEKLQFSALQAMSALLCCGQIFNPSYLQDDSIIYKWLDMLLTSKNE 1564
|| .|| ...||...:..:.|:.||:||||:||||.:|:...|..|..:|||||.:|..::.
Mouse 1179 FSIMFTPL--DRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDL 1241
Fly 1565 KIYQLARDTVVLLLESNPDIGQLLEWVIDRCYTSTPREADACFLALASIFSAKEYPCDHYTSVIT 1629
:::||..:.|:||||.|||...|..|.||||||.:.:.|..||.|:|::...:.||.|..| ::.
Mouse 1242 RVHQLGCEVVMLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGNRNYPFDIVT-LLN 1305
Fly 1630 VTLLMTGCPRVEVHATALQLLQILDKRFF-----------GSVVGTLHSDSDKEDDKVGTLDVLL 1683
:.|........|::..::||:|||:.:.| ||::...| |.|..|
Mouse 1306 LVLFKASDTNREIYEVSMQLMQILEAKLFVHSKKVAEQRPGSILYGTH----------GPLPPL- 1359
Fly 1684 SSAYCRSQRFLSKQLAQLRPELTMSIFSEITHRFQSAREDVRALLLQCLLPWLQNMELVATS--V 1746
|..|...||.:||::.||||:.:|||::.||.:...:.|.::|..|||||.|:|||.:. :
Mouse 1360 ---YSVSLALLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLL 1421
Fly 1747 PPATPLSYIMYFPDSGTRGRR-----------EGTGSTEATEMILNNLFYITAKFSDAHP-RDIE 1799
|.::|.| |:...:.|. .|.||.|||.::||||.|:|||:.|..| .::|
Mouse 1422 PGSSPSS-----PEDEVKDREGEVTASHGLKGNGWGSPEATSLVLNNLMYMTAKYGDEVPGAEME 1481
Fly 1800 ELWGTLC--QFWPNNLKVILRYLVIMSGM-APTELLPYAKRVALYLVRSCPDRLLDELMAELQTV 1861
..|..|. :.|.|||:|.|::|:.:.|: :.|.||||.|:||.||.|:...:.::||:.|||..
Mouse 1482 NAWNALANNEKWSNNLRVTLQFLISLCGVSSDTILLPYIKKVATYLCRNNTIQTMEELLFELQQT 1546
Fly 1862 ETLNCLIERTETPPFYRLTSMRKASSHSADGQAAGGINDSRIQDLAVEKGTIHTKRHSGEDP--- 1923
|.:|.:::..:.|||||.|:..|||: ||.|...| ..|:...:.|..||
Mouse 1547 EPVNPIVQHCDNPPFYRFTASSKASA------AASGTTSS--------SNTVVAGQDSFPDPEES 1597
Fly 1924 --MKIGTCKSDSGIRAYTQAAAAAAAAAVTPGSSGNRPPRGADKIRAASGPSILPRPEDILINDP 1986
:|....:..:.|||:|: ..:..:..|.|:......|.|...:| .|::..
Mouse 1598 KILKESDDRFSNVIRAHTR-----LESRYSNSSGGSYDEDKNDPISPYTG---------WLLSIT 1648
Fly 1987 ELRQEENVELRGTSDAAPNGHPHPLPMPEYGGYFAPLTEFLPDVSLPISGFHRCNVAVMLLTDIV 2051
|.:| |.|||||..||.:|||.::||:...|....||||:||:.:|::|
Mouse 1649 EAKQ-----------------PQPLPMPCSGGCWAPLVDYLPETITPRGPLHRCNIAVIFMTEMV 1696
Fly 2052 VDGIPGIDWTLHLPLMLHILFLGLDHTRIIVREHCKQLCVNLLIVLAEHNDHLTVARILLNSETS 2116
||.....||.|||||:||.:||||||.|..|.||.|:|.::|||.|:.:::...:|.:|| :|.
Mouse 1697 VDHSVREDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHAIASVLL--QTR 1759
Fly 2117 KLDLGLTVPALP------VIDNNFTELHQQFDSYLLHVSPQAAAYALQHNLSSSTIIAAHHQNLS 2175
::....|:...| :....|..|.:. ..||...:.....:.|||..:.....||
Mouse 1760 EMGEAKTLTMQPAYQPEYLYTGGFDFLRED------QSSPVPDSGLNSSSTSSSISLGGSSGNL- 1817
Fly 2176 QTPQSQQQTGSQNGQTTTPPGLTATPAALQINPNNSENSEVPLIHPDEHAPPQPGPSMPIAHVIK 2240
||..|:.......|.| ||.| .
Mouse 1818 --PQMTQEVEDVEAATET----------------------------DEKA--------------S 1838
Fly 2241 SLLKFLAQDTCQPLWNYEDITAKVWAVKSAEQLSCFLKHMVKVFADSYPQARIAERWAQTALQLG 2305
.|::||......|||.:||||.|....|||||||.||:|:|.||.||.....:.:..::.|||..
Mouse 1839 KLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLSNFLRHVVSVFKDSRSGFHLEQHLSEVALQTA 1903
Fly 2306 LSCSSRHYAGRCLQIFRALNVPINSRMLSDILSRLVETVAEQGEDMQGYVTELLLTLEAAVDSLD 2370
|:.||||||||..||||||..|:::..|||:||||||.:.|.|:::||||.|.|||||||||:|.
Mouse 1904 LASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLS 1968
Fly 2371 SDFRPLDVMK--DIF-----KSTPNLNN--------KDGGPNSILPGKKSPSGMTPQSSNYSIPS 2420
|.:| |:| .|:|:|:: |..|..::.||.....|....|.|.:...
Mouse 1969 ------DCLKNSDLFTVLSRSSSPDLSSSSKLTASRKSTGQLNVNPGTPGSGGGGGGSGNTTTAE 2027
Fly 2421 HGR-STSYSVSYCGRKANNSPCDKQVELRNRSS----GIDLERSVVC-KFGVGGGGAGSALSRSR 2479
..| ..|:|| .|:..:.:||| ...|:|...| :.|:. |::|
Mouse 2028 RSRHQRSFSV------------PKKFGVVDRSSDPPRSATLDRIQACTQQGLS--------SKTR 2072
Fly 2480 SAQSLK-MLGDTATQDDKMTILAQLFWLSVSLLESDYEHEFMLALRLLTRVLHRLPLDRPDARDK 2543
|..||| .|.|.:.......:||.:||::|:|:|||:|.|:::|||||.|:|..:||::.:.|:|
Mouse 2073 SNSSLKESLTDPSHVSHPTNLLATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLEKAENREK 2137
Fly 2544 VEKLQQQLKWTAYPGVHALLLKGCTHSATYEPTITLLSQFAPLLTLPVCDPTQSCAFPMNVIALL 2608
:||||.||||..:||:..|||||.|...|.:.|:.|.|....:..:|:.|.:|:..||:||:.||
Mouse 2138 LEKLQAQLKWADFPGLQQLLLKGFTSLTTTDLTLQLFSLLTSVSKVPMVDSSQAIGFPLNVLCLL 2202
Fly 2609 PYMLLHYEDANEICIRSAENIAQVS-TELGAKLENLGTVMTLYSRKTFCKESFQWTKCVVKYLHD 2672
|.::.|:|:.|:.|...||.||||. .|...||.||..|||||...::.::...|...|.:|||:
Mouse 2203 PQLIQHFENPNQFCKDIAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHE 2267
Fly 2673 TYAHMGLHMVAFLIEVLEKGPQQVQVPVLNVIHCMLHYVDLSAPQAQSINADLLRAIGKYLDTAY 2737
.||.:.|:||.:|.|:||||...:|.|:|.||:.:|.|:|||....:..|.::|:.|.||:.:.:
Mouse 2268 AYADITLNMVTYLAELLEKGLPSMQQPLLQVIYSLLSYMDLSVVPVKQFNMEVLKTIEKYVQSIH 2332
Fly 2738 WKDSLKILKLIVTRSSSLQVVPPSDGSSAGLSFSFYGAYPDSDM----------FCKKELAGRTM 2792
|:::|.||||:|:||:|| |:| :|..||: ...|||.|:|:
Mouse 2333 WREALNILKLVVSRSASL-VLP---------------SYQHSDLSKIELHRVWTSASKELPGKTL 2381
Fly 2793 EFTFDVSQTPLIGRRILLKTEEPVAGGAVSTTGSSSLNSTLTNATTVTVAPSAAQQQTNVQMQQQ 2857
:|.||:|:||:||||. ..|.|::.....|.|.....:......
Mouse 2382 DFHFDISETPIIGRRY----------------------DELQNSSGRDGKPRAMAVTRSASSTSS 2424
Fly 2858 RANTNVAALAAAAAAQHQQQQHAIGAGSSVVGTPNSPRRSASLSPADTVPLSGWKRPWMSQCRVR 2922
.:|:|| .||:| ||||..||.|.:
Mouse 2425 GSNSNV-----------------------------------------LVPVS-WKRPQYSQKRTK 2447
Fly 2923 ECLVNLLTTCGQRVGLPKSPSSLSTSLLTGSIATRQSVIFSQSS--DLMERQSSAASSTEETSGP 2985
|.||::|:.|||.|||.|:| |||||... ||.|.|:|..||.: ||
Mouse 2448 EKLVHVLSLCGQEVGLSKNP----------------SVIFSSCGDLDLPEHQTSLVSSED---GP 2493
Fly 2986 QGDLSSGSRRDD--GQPDFTVFKDFDFLEYE----DSIAGESTDNFNWGVRRHQLFEGDEDRLNC 3044
: .....|| .:..|.||:|||||:.| :.:.|||.|||||||||..|...|: |
Mouse 2494 R----EQENMDDTNSEQQFRVFRDFDFLDVELEDGEELQGESMDNFNWGVRRRSLDSLDK----C 2550
Fly 3045 GSGIGGSIKGGHSSAFEDSFSDKTPILSKRKRQIADDSSDEEAESE------------SPLDEDH 3097
...| ..|...|..||.|:|...:.:|:||:|:..:. ||.:|.:
Mouse 2551 DMQI----------LEERQLSRSTPSLNKMSHEDSDESSEEDLTASQILEHSDLIMNLSPSEEAN 2605
Fly 3098 RQSFLKSGYSAVPPTSLSLRERRRRNSVSRSD------TSGSSA--------------------- 3135
....|.|...:.|....|...|......|..| :.||.|
Mouse 2606 PMELLTSACDSAPADPHSFNTRMANFEASLPDINNLQISEGSKAEAVPEEEDTTVHEDDLSSSIN 2670
Fly 3136 -------------------------------------GDLGDLTPCNASPHLPGII-RFSAAIHD 3162
||.|...| .||....|: .|..|..|
Mouse 2671 ELPAAFECSDSFSLDMTEAEEKGNRGLDQYTLASFGEGDRGVSPP--PSPFFSAILAAFQPAACD 2733
Fly 3163 EAEENWRRQVQALLVNQP---SAHTSELLQQLYRLI-KELTFKTVNISKEAKKFFTGIGSQLGNR 3223
:|||.||..:..|:.:.. :.:|..:...|::.| |...|.|.:.:........||||:..:.
Mouse 2734 DAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSS 2798
Fly 3224 ISLFTDLLSSRADPPQVWCSELQATSPKLFETLRFNVLEVQEHLETFFDRKDQVLECLDAVKTSC 3288
:.:|:|.::.|.::.......|..|.:.|:|:|||:||:|:|:.:||:..|..| .:|
Mouse 2799 ----SQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWL----ANC 2855
Fly 3289 KLSLFNEADVAASGLELPSTSSIVYMPFDPASTEV----VLDLGRSLYKLMFQLLLLIESNHKIS 3349
|.:. |..:..|: |...|.|....:: .|:|.:.||||.||||||.:|..|:.
Mouse 2856 KATF---AGGSRDGV-------ITCQPGDSEEKQMESLAQLELCQRLYKLHFQLLLLYQSYCKLI 2910
Fly 3350 SNVVNHFRMNEDMHDISDLYALVRDALVRYISEAELDCLESSTS-------TEGEHTPTPSPGLP 3407
..| |::|.:..|:. :.|.:|:.:.:..|::.: .||..: .|...
Mouse 2911 GQV----------HEVSSVPELLN--MSRELSDLKRNLKEATAAIATDPLYIEGAWS---EPTFT 2960
Fly 3408 MTPEEFEAVLTEHIDLQRWPSAIAHVRQYRRISTLNASGYQNVTIFSYNSADNRQKWDEISVILN 3472
.|....:::| |.:.......|:..:::.|.: :.| .||. :|:| ||:..:||
Mouse 2961 STEAAIQSML-ECLKNNELGKALRQIKECRSL-------WPN-DIFG-SSSD-----DEVQTLLN 3010
Fly 3473 AYAHGIMKDRTAEAFIVSKSDSEVFEIYAILSENLYQVSSALTNMEI 3519
.|.......:|....:|. |:..:.||...|.| .||||
Mouse 3011 IYFRHQTLGQTGTYALVG-SNHSLTEICTKLME---------LNMEI 3047
| 
