Protein Alignment fry and FRYL

DIOPT Version :9

• Sequence 1: NP_001246701.1
• Gene: fry / 39122
• FlyBaseID: FBgn0016081
• Length: 3544
• Species: Drosophila melanogaster
• Sequence 2: XP_024309756.1
• Gene: FRYL / 285527
• HGNCID: 29127
• Length: 3120
• Species: Homo sapiens
• Alignment Length: 3447
• Identity: 1235/3447 - (35%)
• Similarity: 1800/3447 - (52%)
• Gaps: 660/3447 - (19%)

  Fly   279 RPGEIVMRNLFSDFTAQAEKKIELVMLESADKNLSKLLQRGEDQQFDQLLSALGSVAEHCLPSLL 343
            :|||.|:::||::|..|||||||:||.|..:|.||:.||||||.|||||:|::.|||||||||||
Human   103 KPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLISSMSSVAEHCLPSLL 167

  Fly   344 HTLLAWHRRQLSDMEIKNDLKKPAPSGSSSQAATNKPTVDLDFQLQRREAAVEFIFCLALIEILK 408
            .||..|:||| :..|.::...:|.   ||:::..::...:.|:.|:||:.||:|||||.|:|:||
Human   168 RTLFDWYRRQ-NGTEDESYEYRPR---SSTKSKGDEQQRERDYLLERRDLAVDFIFCLVLVEVLK 228

  Fly   409 QLPYHPGHEDLVRSIENLAFKHFKYKDGLQNNPNALNIHMIADLYAEVIGVLAQSRFASVRKRFM 473
            |:|.||..:.||..:.||||||||:|:| .:..|..|:|:|||||||||||||||:|.:|||:|:
Human   229 QIPVHPVPDPLVHEVLNLAFKHFKHKEG-YSGTNTGNVHIIADLYAEVIGVLAQSKFQAVRKKFV 292

  Fly   474 SELKELRGKEVSPTTTQSIISLLMGMKFFRVKMVPIEEFEASFQFMHECGQYFLEVKDKDIKHAL 538
            :||||||.||.||...||:|||:||||||||||.|:|:||||||||.||.|||||||||||||||
Human   293 TELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHAL 357

  Fly   539 AGLFVEILVPVAAAVKNEVNVPCVKNFVELLYVQTLDASTKSKHRLALFPLVTCLLCVSQKTFFL 603
            ||||||||:||||||||||||||:|||||:||..|.:.|::.||.|||:||:|||||||||.|||
Human   358 AGLFVEILIPVAAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFL 422

  Fly   604 TNWHYFLAMCLSNLK---------------NRDAKMSRVALESLFRLLWVYMIRIKCESNSATHS 653
            .|||.||..|||:||               |:|.||||||||||:||||||:||||||||:.|.|
Human   423 NNWHIFLQNCLSHLKMPSNNSIRKQIETLQNKDPKMSRVALESLYRLLWVYVIRIKCESNTVTQS 487

  Fly   654 RLQSIVNSLFPKGSKGVVPRDTPLNIFVKIIQFIAQERLDFAMREIVYDLLCVGRSIK-LILNPE 717
            ||.|||::||||||:.|||||||||||||||||||||||||||:||::|||.||:|.| ..:|||
Human   488 RLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVGKSTKTFTINPE 552

  Fly   718 RMSIGLRAFLVVADSLQQKAGEPPMPRTVPVLPSGNTLRVKKTF-NKMYVLLTDDTARSIGMSTY 781
            ||:||||.|||:|||||||.||||||.|..:|||||||||||.| ||   .|||:.|:.||||.|
Human   553 RMNIGLRVFLVIADSLQQKDGEPPMPTTGVILPSGNTLRVKKIFLNK---TLTDEEAKVIGMSVY 614

  Fly   782 FPHVRRVFVDILRALDVHYGRPLMMTNTQNQNKEPDEMLSGERKPRIDLFRTCVAAVPRLIPDTM 846
            :|.||:....|||.||...|||:.||:.|..||||::|::|||||:|||||||:||:||||||.|
Human   615 YPQVRKALDSILRHLDKEVGRPMCMTSVQMSNKEPEDMITGERKPKIDLFRTCIAAIPRLIPDGM 679

  Fly   847 TPHELVDMLSRLSVHMDEELRILTHQSLTTLVIDFPDWRQDVVHGYTQFLVRDVTDTYPQLLENC 911
            :..:|:::|:||::|||||||.|...:|..|::||||||:||:.|:..|:||:|||.:|.||:|.
Human   680 SRTDLIELLARLTIHMDEELRALAFNTLQALMLDFPDWREDVLSGFVYFIVREVTDVHPTLLDNA 744

  Fly   912 TRILFTFLNIWRCATNVNGNNTTSAPSGATNVVNTSQAKMTTATTTTTVVQATVVQVTSAPAKDT 976
            .::|...:|.|:.|..::..|..
Human   745 VKMLVQLINQWKQAAQMHNKNQD------------------------------------------ 767

  Fly   977 ASSQLSKQQHLNTASSAASSITTSSGMSSITQHTVLNMASDVGKKNEIPLATTLHFVEGFALVLL 1041
                                          |||.|.|.||........|.:...|.|||||||:|
Human   768 ------------------------------TQHGVANGASHPPPLERSPYSNVFHVVEGFALVIL 802

  Fly  1042 CNYRTYLRKLAALILKEVKNLMRALGIPETEPPL-IDVMDRCVPGIIEKCLPQLPQTEKTAILNA 1105
            |:.|...|:||..:|:|::.|...|.||:.:..| ||||||..|.|:|..:......:.|.:...
Human   803 CSSRPATRRLAVSVLREIRALFALLEIPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLYCP 867

  Fly  1106 NCIDLQWIAERSSGVWLAGLTDDNSKSSTSTLN-LSQSSSTPNASATAASSPQLPFDPWATCLFG 1169
            :.||||.:||     |       ||...:...: :|.|.....|..|...      |||...|..
Human   868 SSIDLQTLAE-----W-------NSSPISHQFDVISPSHIWIFAHVTQGQ------DPWIISLSS 914

  Fly  1170 LLERQNVLQQCPSAVAQAWPICFTRLNALYSVIDPTPVSDNRASLLRSSAPTKKVPTESQKDSYL 1234
            .|:::|:.:.|.:||:.||...:|||..|...:|           :.|....|||.|.:..|||:
Human   915 FLKQENLPKHCSTAVSYAWMFAYTRLQLLSPQVD-----------INSPINAKKVNTTTSSDSYI 968

  Fly  1235 RLWRNQ--VACAMRLVPQIPSV-AVRCASPDLSLSLQDQSDSRSLSDSLDNIPSNVFGPEGIVTR 1296
            .||||.  :.|:........|. :|||:.|:
Human   969 GLWRNYLILCCSAATSSSSTSAGSVRCSPPE---------------------------------- 999

  Fly  1297 FTLPLSYGRKEARQKRLGSSPDSLNADRSDKSAMGSASPQALYKLVVPLLRCEVVDVRDAAVNAL 1361
                           .|.|:|||  ....|...:|..||.:|:|.:||::|.|.:::.::.|..|
Human  1000 ---------------TLASTPDS--GYSIDSKIIGIPSPSSLFKHIVPMMRSESMEITESLVLGL 1047

  Fly  1362 GLINHDALKDLMEELVVYIREAVDCKQENMRRRRRRDALRLQVVRVLEKIAENGTFGVSTC-VLE 1425
            |..|..|.::|:|||...|:||::.:.|||:||||||.||:|:||:.|.:|:.|....|.. .|:
Human  1048 GRTNPGAFRELIEELHPIIKEALERRPENMKRRRRRDILRVQLVRIFELLADAGVISHSASGGLD 1112

  Fly  1426 RDTMSLHPTFVLYISGAMGYLTSETDKDNLSIREVKAHFCNFIRKMIKNFPLEACATLL-SRVLK 1489
            .:|..|:.|.:.|:......|.:|.:||:.::::::.||...:..:|:|.|:....::. .:.|:
Human  1113 NETHFLNNTLLEYVDLTRQLLEAENEKDSDTLKDIRCHFSALVANIIQNVPVHQRRSIFPQQSLR 1177

  Fly  1490 RNLFNLFAAWCGSFS---KPLGYTMQSDHTLEEEKLQFSALQAMSALLCCGQIFNPSYLQDDSII 1551
            .:||.||:.|.|.||   .||  ...||..::..:.|:.||:||||:||||.:.:...|..|..:
Human  1178 HSLFMLFSHWAGPFSIMFTPL--DRYSDRNMQINRHQYCALKAMSAVLCCGPVADNVGLSSDGYL 1240

  Fly  1552 YKWLDMLLTSKNEKIYQLARDTVVLLLESNPDIGQLLEWVIDRCYTSTPREADACFLALASIFSA 1616
            |||||.:|.|.::|::||..:.|.||||.|||...|:.|.:|||||.:.|.|..||.|:|::|..
Human  1241 YKWLDNILDSLDKKVHQLGCEAVTLLLELNPDQSNLMYWAVDRCYTGSGRVAAGCFKAIANVFQN 1305

  Fly  1617 KEYPCDHYTSVITVTLLMTGCPRVEVHATALQLLQILDKRFFGSVVGTLHSDSDKEDDKVGTLDV 1681
            ::|.|| ...::.:.|.........::..|:||||||:.:.|...    |....:..|  |.|..
Human  1306 RDYQCD-TVMLLNLILFKAADSSRSIYEVAMQLLQILEPKMFRYA----HKLEVQRTD--GVLSQ 1363

  Fly  1682 L--LSSAYCRSQRFLSKQLAQLRPELTMSIFSEITHRFQSAREDVRALLLQCLLPWLQNMELVAT 1744
            |  |...|..|...||::||:..||||::|||||:.|.|:|....|.::|..||||:.|:|||..
Human  1364 LSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTAHPAGRQVMLHYLLPWMNNIELVDL 1428

  Fly  1745 SVPPATPLSY------------IMYFPDSGTRGRREGTGSTEATEMILNNLFYITAKFSDAHP-R 1796
            . |..|...:            :|.......||  ||.||.:||.|:||||.|:|||:.|... .
Human  1429 K-PLPTARRHDEDEDDSLKDRELMVTSRRWLRG--EGWGSPQATAMVLNNLMYMTAKYGDELAWS 1490

  Fly  1797 DIEELWGTLCQFWPNNLKVILRYLVIMSGM-APTELLPYAKRVALYLVRSCPDRLLDELMAELQT 1860
            ::|.:|.||...||.|||:||.:|:.:.|: :...||||.|:|.:||.|....:||:||::|||.
Human  1491 EVENVWTTLADGWPKNLKIILHFLISICGVNSEPSLLPYVKKVIVYLGRDKTMQLLEELVSELQL 1555

  Fly  1861 VETLNCLIERTETPPFYRLTSMRK---------ASSHSADGQAAGGINDSRIQDLAVEKGTIHTK 1916
            .:.::..:...:.||:||:||..|         :||::......|..::..|:: .:|:..:|..
Human  1556 TDPVSSGVTHMDNPPYYRITSSYKIPSVTSGTTSSSNTMVAPTDGNPDNKPIKE-NIEESYVHLD 1619

  Fly  1917 RHSGEDPMKIGTCKSDSGIRAYTQAAAAAAAAAVTPGSSGNRP-PRGADKIRAASGPSILPRPED 1980
            .:||.:                               |..||. .|...:..::||.|.
Human  1620 IYSGLN-------------------------------SHLNRQHHRLESRYSSSSGGSY------ 1647

  Fly  1981 ILINDPELRQEENVELRGTSDAAP-----------NGHPHPLPMPEYGGYFAPLTEFLPDVSLPI 2034
                     :||.      ||:.|           :....|||.|..||.::||.:::|:.|.|.
Human  1648 ---------EEEK------SDSMPLYSNWRLKVMEHNQGEPLPFPPAGGCWSPLVDYVPETSSPG 1697

  Fly  2035 SGFHRCNVAVMLLTDIVVDGIPGIDWTLHLPLMLHILFLGLDHTRIIVREHCKQLCVNLLIVLAE 2099
            ...||||:||:||||:::|....::|..:|.|:||.:|:|.||....|.||||:|.::||||:..
Human  1698 LPLHRCNIAVILLTDLIIDHSVKVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGP 1762

  Fly  2100 HNDHLTVARILLNSETSKLDLGLTVPALPVIDNNFTELHQQFDSYLLHVSPQAAAYALQHNLSSS 2164
            :::..|||.:||.::.......|||..:..:|.|||.....|
Human  1763 NSNIRTVASVLLRNKEFNEPRVLTVKQVAHLDYNFTAGINDF----------------------- 1804

  Fly  2165 TIIAAHHQNLSQTPQSQQQTGSQNGQTTTPPGLTATPAALQINPNNSENSEV--PLIHPDEHAPP 2227
                        .|..|....:.:|.::     ::|.:::.:..|::..|.:  .:::..:.:..
Human  1805 ------------IPDYQPSPMTDSGLSS-----SSTSSSISLGNNSAAISHLHTTILNEVDISVE 1852

  Fly  2228 QPGPSMPIAHVIKSLLKFLAQDTCQPLWNYEDITAKVWAVKSAEQLSCFLKHMVKVFADSYPQA- 2291
            |.|.       :|:|::|:......||||:||::||..::||||||:.||||:|.||..|..:.
Human  1853 QDGK-------VKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKHVVSVFKQSSSEGI 1910

  Fly  2292 RIAERWAQTALQLGLSCSSRHYAGRCLQIFRALNVPINSRMLSDILSRLVETVAEQGEDMQGYVT 2356
            .:....::.|||..|||||||||||..||||||..|:.:..|||:||||||||.:.|||.||:|.
Human  1911 HLEHHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDPGEDAQGFVI 1975

  Fly  2357 ELLLTLEAAVDSLDSDFRPLDVMKDIFKST---PNLNNKDGGPNSILPGKKSPSGMTPQSSNY-S 2417
            |||||||:|:|:|....:..|::..:.:::   |.:.||... |....|:.:.|.....||:| .
Human  1976 ELLLTLESAIDTLAETMKHYDLLSALSQTSYHDPIMGNKYAA-NRKSTGQLNLSTSPINSSSYLG 2039

  Fly  2418 IPSHGRSTSYSVSYCGRKANNSPCDKQVELRNRSSGIDLERSVVCKFGVGGGGAGSALSRSRSAQ 2482
            ..|:.||.|..:|..|.:..:         |.||:.:|:..        |.....|:|:|:||..
Human  2040 YNSNARSNSLRLSLIGDRRGD---------RRRSNTLDIMD--------GRINHSSSLARTRSLS 2087

  Fly  2483 SLKMLG--DTATQDDKMTILAQLFWLSVSLLESDYEHEFMLALRLLTRVLHRLPLDRPDARDKVE 2545
            ||:..|  |..:..:...::|.:||::.||||||||:|::||||||.::|..||||:.::|:|:|
Human  2088 SLREKGMYDVQSTTEPTNLMATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIE 2152

  Fly  2546 KLQQQLKWTAYPGVHALLLKGCTHSATYEPTITLLSQFAPLLTLPVCDPTQSCAFPMNVIALLPY 2610
            .:|.:||||.:||:..|.|||.|.::|.|.|:.|||:...:....:.||:|...||:|::.|||:
Human  2153 NVQSKLKWTNFPGLQQLFLKGFTSASTQEMTVHLLSKLISVSKHTLVDPSQLSGFPLNILCLLPH 2217

  Fly  2611 MLLHYEDANEICIRSAENIAQV-STELGAKLENLGTVMTLYSRKTFCKESFQWTKCVVKYLHDTY 2674
            ::.|::...:.|..:|..||:| :.|....|.||..:|:|||..|:.::...|...|.:||||::
Human  2218 LIQHFDSPTQFCKETASRIAKVCAEEKCPTLVNLAHMMSLYSTHTYSRDCSNWINVVCRYLHDSF 2282

  Fly  2675 AHMGLHMVAFLIEVLEKGPQQVQVPVLNVIHCMLHYVDLSAPQAQSINADLLRAIGKYLDTAYWK 2739
            :....::|.:|.|:||||...:|..:|.:|:.:|.::||||..|:..|.::::.||||:.:.|||
Human  2283 SDTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQSPYWK 2347

  Fly  2740 DSLKILKLIVTRSSSLQVVPPSD------GSSAGLSFSFYGAYPDSDMFCKKELAGRTMEFTFDV 2798
            ::|.||||:|:||:||  |.|||      |.:.....||...:.:    ..|||.|:|::|.||:
Human  2348 EALNILKLVVSRSASL--VVPSDIPKTYGGDTGSPEISFTKIFNN----VSKELPGKTLDFHFDI 2406

  Fly  2799 SQTPLIGRRILLKTEEPVAGG------AVSTTGSSSLNSTLTNATTVTVAPSAAQQQTNVQMQQQ 2857
            |:||:||.:.   .::..|.|      .::.|.|:|..|:.:|:..:
Human  2407 SETPIIGNKY---GDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNAL------------------ 2450

  Fly  2858 RANTNVAALAAAAAAQHQQQQHAIGAGSSVVGTPNSPRRSASLSPADTVPLSGWKRPWMSQCRVR 2922
                                                            ||:| ||||.:||.|.|
Human  2451 ------------------------------------------------VPVS-WKRPQLSQRRTR 2466

  Fly  2923 ECLVNLLTTCGQRVGLPKSPSSLSTSLLTGSIATRQSVIFSQSSDLM--ERQSSAASSTEETSGP 2985
            |.|:|:|:.||...||||:|                ||:||.:.||.  ::|:|..|:||:.:..
Human  2467 EKLMNVLSLCGPESGLPKNP----------------SVVFSSNEDLEVGDQQTSLISTTEDINQE 2515

  Fly  2986 Q----GDLSSGSRRDDGQPDFTVFKDFDFLEYE-DSIAGESTDNFNWGVRRHQLFEGDEDRLNCG 3045
            :    .|.||       :..|.||||||||:.| :...|||.|||||||||..|...|
Human  2516 EEVAVEDNSS-------EQQFGVFKDFDFLDVELEDAEGESMDNFNWGVRRRSLDSID------- 2566

  Fly  3046 SGIGGSIKGGHSSAFEDSFSDKTPILSKRKRQIADDSSDEEA--------------ESESPLDE- 3095
                   ||...|..|...|..||.|:...::..|:||:|||              .|:|..||
Human  2567 -------KGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAALTASQILSRTQMLNSDSATDET 2624

  Fly  3096 --DHRQSFLKS----------------------------GYSAVP-------------------- 3110
              ||....|:|                            ..|.:|
Human  2625 IPDHPDLLLQSEDSTGSITTEEVLQIRDETPTLEASLDNANSRLPEDTTSVLKEEHVTTFEDEGS 2689

  Fly  3111 --------------------------------PTS-------LSLRERRRRNSVSRSDTSGSSAG 3136
                                            |.|       |:|:|...|.....:|.||.|:.
Human  2690 YIIQEQQESLVCQGILDLEETEMPEPLAPESYPESVCEEDVTLALKELDERCEEEEADFSGLSSQ 2754

  Fly  3137 DLGD-------LTPCNASPHLPGII-RFSAAIHDEAEENWRRQVQALLVNQPSAHTSELLQQLYR 3193
            |..:       .|....||.|..|| .|....:|:.||.||..|..:|.:...:..........|
Human  2755 DEEEQDGFPEVQTSPLPSPFLSAIIAAFQPVAYDDEEEAWRCHVNQMLSDTDGSSAVFTFHVFSR 2819

  Fly  3194 LIKELTFKTVNISKEAKKFFTGIGSQLGNRISLFTDLLSSRADPPQVWCSELQATSPKLFETLRF 3258
            |.:.:..|...|:.||..|......::|.:.....:::...::.|.|:.......|..|.|||:|
Human  2820 LFQTIQRKFGEITNEAVSFLGDSLQRIGTKFKSSLEVMMLCSECPTVFVDAETLMSCGLLETLKF 2884

  Fly  3259 NVLEVQEHLETFFDRKDQVLECLDAVKTSCKLSLFNEADVAASGLELPSTSSIVYMPFDPASTEV 3323
            .|||:||||:|:..:::...:.||    .||.:...:.|             :..:..|....|:
Human  2885 GVLELQEHLDTYNVKREAAEQWLD----DCKRTFGAKED-------------MYRINTDAQQMEI 2932

  Fly  3324 V--LDLGRSLYKLMFQLLLLIESNHKISSNVVNHFRMNEDMHDISDLYALVRDALVRYISEAELD 3386
            :  |:|.|.||||.||||||.::..|: .|.||..:...::.::|:..|.:...|    .|||
Human  2933 LAELELCRRLYKLHFQLLLLFQAYCKL-INQVNTIKNEAEVINMSEELAQLESIL----KEAE-- 2990

  Fly  3387 CLESSTSTEGEHTPTPSPGLPMTPEEFEAVLTEHIDLQRWPSAIAHVRQYRRISTLNASGYQNVT 3451
                 :::|.|.... |.....|.|.....|.|.:..:.:.||:|.|:.:|.:...:..|
Human  2991 -----SASENEEIDI-SKAAQTTIETAIHSLIETLKNKEFISAVAQVKAFRSLWPSDIFG----- 3044

  Fly  3452 IFSYNSADNRQKWDEISVILNAYAHGIMKDRTAEAFIV------SKSDSEVFEIYAILSENLYQV 3510
                 |.::    |.:..:|:.|.|.....:|....::      |:::.::.|:...:.|:|..|
Human  3045 -----SCED----DPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMV 3100

  Fly  3511 SS 3512
            .|
Human  3101 QS 3102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fry	NP_001246701.1	MOR2-PAG1_N	389..923	CDD:290922	363/550 (66%)
		MOR2-PAG1_mid	1326..2098	CDD:290928	276/813 (34%)
		MOR2-PAG1_C	2501..2753	CDD:290925	105/252 (42%)
FRYL	XP_024309756.1	MOR2-PAG1_N	209..756	CDD:316718	363/550 (66%)
		MOR2-PAG1_mid	794..1966	CDD:316723	436/1363 (32%)
		MOR2-PAG1_C	2108..2361	CDD:316721	105/252 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159607
Domainoid	1	1.000	741	1.000	Domainoid score	I97
eggNOG	1	0.900	-	-		E1_KOG1825
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H103956
Inparanoid	1	1.050	1700	1.000	Inparanoid score	I75
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55726
OrthoDB	1	1.010	-	-		D11874at2759
OrthoFinder	1	1.000	-	-		FOG0001786
OrthoInspector	1	1.000	-	-		otm40689
orthoMCL	1	0.900	-	-		OOG6_102307
Panther	1	1.100	-	-	LDO	PTHR12295
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3991
SonicParanoid	1	1.000	-	-		X1916
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840