DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fry and mor2

DIOPT Version :9

Sequence 1:	NP_001246701.1	Gene:	fry / 39122	FlyBaseID:	FBgn0016081	Length:	3544	Species:	Drosophila melanogaster
Sequence 2:	NP_596172.1	Gene:	mor2 / 2541317	PomBaseID:	SPBP19A11.04c	Length:	2196	Species:	Schizosaccharomyces pombe

Alignment Length:	3137	Identity:	576/3137 - (18%)
Similarity:	1033/3137 - (32%)	Gaps:	1143/3137 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 PSYTQAEMHALAARVASVETSAPRPGEIVMRNLFSDFTAQAEKKI--------------ELVMLE 306
            |.|::.:.|...              :..:..||:.|...:|:||              |.|...
pombe    16 PLYSEKQDHTAV--------------DYALHILFTQFVRLSEQKISFLSRYHANEGKNAEPVRFN 66

  Fly   307 SADKNLSKLLQRGEDQQFDQLLSALGSVAEHCLPSLLHTLLAWHRRQLSDMEIKNDLKKPAPSGS 371
            ..::....||::|||.:||:.:.||.::|.....:::.:||.|.:       ::.|:    .|.|
pombe    67 VGEQEAILLLKKGEDNEFDRCIQALVALASSKPVAVIESLLCWRK-------VRVDI----TSSS 120

  Fly   372 SSQAATNKPTVDLDFQLQRREAAVEFIFCLALIEILKQLPYHPGHEDLVRSIENLAFKHFKYKDG 436
            .:....|          :||.:...:|.|..|.||.:.:|.:...|..|..:....|....   .
pombe   121 GTPRVVN----------ERRSSISIYILCRVLTEIAETIPSNALEESTVSCLLECVFHQLL---S 172

  Fly   437 LQNNPNALNIHMIA--DLYAEVIGVLAQSRFASVRKRFMSELKEL-------RGKEVSPTTTQSI 492
            .:|.|.:.:...:|  :.:|.::|.:::..|..|..||:.|::.|       |.||.      .:
pombe   173 AKNLPVSSSYFSLANWESFAFLVGSMSRFNFVMVSDRFIEEIEHLEKSGCDSRQKET------VL 231

  Fly   493 ISLLMGMKFFRVKMVPIEEFEASFQFMHECGQYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEV 557
            :.||..|::.|:::.|....|.|..|:.....:|::. :..:|...|.|..::|.|:.:....||
pombe   232 VHLLRAMRYLRLQLYPTTLLEESIAFLQSLTSFFMKA-NTALKIEYAYLMEQLLRPLISRATFEV 295

  Fly   558 NVPCVKNFVELLYVQTLDASTKSKHRLALFPLVTCLLCVSQKTFFLTNWHYFLAMCLSNLKNRDA 622
            |:|.....:|.:|...|...||:|:....||....|||:|.|.|||.:|...|......:|:|
pombe   296 NIPAWSRTIETIYPVVLKMCTKTKYWNVFFPFCCTLLCLSPKQFFLKHWISSLDAAFFRVKDR-- 358

  Fly   623 KMSRVALESLFRLLWVYMIRIKCESNSATHSRLQSIVNSLFPKGSK-GVVPRDT--PLNIFVKII 684
            ::....|..|.|::|.|..:.| |..|..:|.:.:|:.|.|..|.| .|||..|  .|:.:.:|:
pombe   359 RLRNTGLPHLSRVVWTYSNQYK-EEPSIMNSNISNILKSGFSIGKKFSVVPFATLEELDGYAQIV 422

  Fly   685 QFIAQERLDFAMREIVYDLLCVGRSIKLILNPERMSIGLRAFLVVADSLQQKAGEPPMPRTVPVL 749
            :.:.....:..::||:..|..  .:....:.||::.|.:|:...:...::.|..:
pombe   423 RVVGAHFPELVIKEILTPLST--DAFTENIGPEKLMIVVRSVYYILHDMKYKKSD---------- 475

  Fly   750 PSGNTLRVKKTFNKMYVLLTDDTARSIGMSTYFPHVRRVFVDILRALDVHYGRPLMMTNTQNQNK 814
                                         ||.|.::...|||:   .:|..|.||... ..|.::
pombe   476 -----------------------------STIFEYIEFEFVDL---HEVAVGTPLQQF-VHNLSQ 507

  Fly   815 EPDEMLSGERKPRIDLFRTCVAAVPRLIPDTMTPHELVDMLSRLSVHMDEELRILTHQSLTTLVI 879
                                               :|:.::.:||.:.:..|......||..|.|
pombe   508 -----------------------------------KLLFLVFQLSTNTNCYLDSKNATSLLALYI 537

  Fly   880 D----FP----DWRQDVVHGYTQFLVRDVTDTYPQLLENCT-RILFTFLNIWRCATNVNGNNTTS 935
            :    ||    ...|.|:..|.:.|             ||: :|:.|          |..|:...
pombe   538 NALKVFPCLMGKLEQRVIDAYVKCL-------------NCSNKIIHT----------VCHNSLIY 579

  Fly   936 APSG---ATNVVNTSQAKMTTATTTTTVVQATVVQVTSAPAKDTASSQLSKQQHLNTASSAASSI 997
            ..||   :.:|::....|:...:.........|:::           .:|:|:   ......:|:
pombe   580 FSSGLKMSKSVISCLSRKLVKGSEYLLRTYHEVIRI-----------WISQQE---AVIEKRNSV 630

  Fly   998 TTSSGMSSITQHTVLNMASDVGKKNEIPLATTLHFVEGFALVLLCNYRTYLRKLAALILKEVKNL 1062
            .::...:|...:|..::..|.   ::|...|.:..::...::.|.:....:||.|..:|.:||.|
pombe   631 LSNKSCASSESNTPASVKQDY---DDIQSWTIIEEIQSLGVLHLSSPSVGIRKFAVALLNDVKQL 692

  Fly  1063 MR----------ALGIPETEPPLIDVMDRCVPGI--IEKCLPQLPQTEKTAILNANCIDLQWIAE 1115
            ..          .:|...:||.::||:..|...|  :|..||       ||            ||
pombe   693 NTEYLMLSSDKVEVGDIYSEPTIVDVLKDCDSSILSVESHLP-------TA------------AE 738

  Fly  1116 RSSGVWLAGLTDDNSKSSTSTLNLSQSSSTPNASATAASSPQLPFDPWATCLFGLLERQNVLQQC 1180
            ||.   |....:|.:|.  ..|.|:.|:|..:.|.            |          .||.
pombe   739 RSR---LRKFINDGTKD--MLLKLATSNSGVDISI------------W----------YNVF--- 773

  Fly  1181 PSAVAQAWPICFTRLNALYSVIDPTPVSDNRASLLRSSAPTKKVPTESQKDSYLRLWRNQVACAM 1245
            |..:    .:||.|.        ||.:     :|||::...|
pombe   774 PRFI----KVCFERF--------PTTM-----ALLRNTVCEK----------------------- 798

  Fly  1246 RLVPQIPSVAVRCASPDLSLSLQDQSDSRSLSDSLDNIPSNVFGPEGIVTR-------------F 1297
                          .|.:::.|..:.:|..|:.:|.:...|...||.::.:             :
pombe   799 --------------LPSITMQLLSRIESSELNFNLKSAVKNDNFPEFLLVQWKLYLIVACCTITY 849

  Fly  1298 TLPLSYGRKEARQKRLGSSPDSLNADRSDKSAMGSASPQALYKLVVPLLRCEVVDVRDAAVNALG 1362
            |..:.|...:.|  |..::..|.|..|..:..:...|.::|:.:|:||:..|...:|:|.|.|:|
pombe   850 TSNVDYSHTDLR--RTLTAVQSGNHLRGLQETIKITSAESLFSMVLPLIFTEFSPIREAVVFAIG 912

  Fly  1363 LINHDALKDLMEELVVYIREAVDCKQE---------NMRRRRRRD-ALRLQVVRVLEKIAENGTF 1417
            .||.:|...|:..|..||.......||         :::||.:.| .||.::..:         |
pombe   913 CINVNAFPQLVRSLKPYISVLKQDHQEFIFAGLNFPSVKRRNKPDLLLRSEIAHI---------F 968

  Fly  1418 GVSTCVL-------ERDTMSLHPTFVLYISGAMGYLTSETDKDNLSIREVKAHFCNFIRK--MIK 1473
            .:::.:|       :|:.:|:...|:..:.|.:.....:.|:..|.:|   .:|...:.|  :::
pombe   969 AMTSHLLLHELLNEDREALSVISEFLKDLKGFLSTPNVQADEKYLKLR---CYFSQLLEKVLLVQ 1030

  Fly  1474 N-------FPLE---ACATLL--------SRVLKRNLFNLFAAWCGSFSKPLGYTMQSDHTLE-- 1518
            |       .|..   :|..||        :|.:.:|...|..|.....:|.:   .:.|..|.
pombe  1031 NLHPSSEVLPFSGRASCWKLLDEWTGFGPARAITKNREELMRAHIRGNNKDI---RERDKLLASF 1092

  Fly  1519 ---EEKLQFSALQAMSALLCCG----QIFNPSYLQDDSIIYKWLDMLLTSKNEKIYQLARDTVVL 1576
               ::.|::.|::||.| ||..    ::....:|.|..|:..|...:..|.::.|..|||..:..
pombe  1093 EAGKQNLEYLAIKAMIA-LCTAKLQQELTEGVFLFDIEILLNWFTAVFGSPSKAIVGLARKGLTA 1156

  Fly  1577 LLESNPDIGQLLEWVIDRCYTSTPRE--ADACFLALASIFSAKEYPCDHYTSVITVTLLMTGCPR 1639
            ||..|.....||:.||:||::....:  ::..||:|:.:.............::.:.|:......
pombe  1157 LLLENSSNEVLLQKVINRCFSKEISQTISNYYFLSLSEMLIQINPNNLSKPKLLPLCLVNLSTNN 1221

  Fly  1640 VEVHATALQLLQILDKRFFGSVVGTLHSDSDKEDDKVGTLDVLLS----------SAYCRSQRFL 1694
            :.|...|.:||            |..|.::       .|:..|:.          :.|.:.|...
pombe  1222 LSVRLKAFELL------------GNFHLNN-------FTMTALMEFKTFLESSNPALYLKPQYLF 1267

  Fly  1695 SKQLAQLRPELTMSIFSEITHRFQSAREDVRALLLQCLLPWLQNMELVATSVPPATPLSYIMYFP 1759
            |.|||....|.:.::.||....|....:..|. |:..|||||||:|| ...|...|..|:
pombe  1268 SVQLASDFTEDSFTLTSECLRYFNYGHQHRRG-LVTVLLPWLQNLEL-KMDVENKTFDSF----- 1325

  Fly  1760 DSGTRGRREGTGSTEATEMILNNLFYITAKFSDAHPRDIEELWGTLC-QFWPNNLKVILRYLVIM 1823
                            |.:||.:|..:||||::..|.:||.||.:|. ....:|..|||.:|:..
pombe  1326 ----------------TAVILIDLIEVTAKFTNDLPNEIEALWTSLALSRHKSNWTVILFFLMQQ 1374

  Fly  1824 SGMAPT-ELLPYAKRVALYLVRSCPDRLLDELMAEL-QTVETLNCLIERTETPPFYRLTSMRKAS 1886
            .....| ..:...:::.:||.::       ||:::| .|:.:..|
pombe  1375 CYQRKTFSFVDCTRQITIYLAKT-------ELLSDLYSTLLSFVC-------------------- 1412

  Fly  1887 SHSADGQAAGGINDSRIQDLAVEKGTIHTKRHSGEDPMKIGTCKSDSGIRAYTQAAAAAAAAAVT 1951

pombe  1413 ----------------------------------------------------------------- 1412

  Fly  1952 PGSSGNRPPRGADKIRAASGPSILPRPEDILINDPELRQEENVELRGTSDAAPNGHPHPLPMPEY 2016
                                      |.::...:.|:.:....:|..|
pombe  1413 --------------------------PANVSNENQEVYKFSLEDLSST----------------- 1434

  Fly  2017 GGYFAPLTEFLPDVSLPISGFHRCNVAVMLLTDIVVDGIPG-IDWTLHLPLMLHILFLGLDHTRI 2080
              |.|.|.:..|.....|| :..|.::::||.||:.:  |. |..|..:..:||..|:..||...
pombe  1435 --YVANLEDLFPSEKNHIS-YSPCQLSLLLLMDILPN--PSIITVTDDVATILHAAFIQFDHYSR 1494

  Fly  2081 IVREHCKQLCVNLLIVLAEHNDHLTVARILLNSETSKLDLGLTVPALPVIDNNFTELHQQFDSYL 2145
            ||:|.|:|:             ...|.|.:|..| .:||..                    |:|
pombe  1495 IVQEQCQQI-------------FQYVVRKVLAME-GRLDYD--------------------DAY- 1524

  Fly  2146 LHVSPQAAAYALQHNLSSSTIIAAHHQNLSQTPQSQQQTGSQNGQTTTPPGLTATPAALQINPNN 2210
                       ...|:.||.|                 ||.: |:|.....|.
pombe  1525 -----------FDFNVESSLI-----------------TGLR-GKTKKEDDLV------------ 1548

  Fly  2211 SENSEVPLIHPDEHAPPQPGPSMPIAHVIKSLLKFLAQDTCQPLWNYEDITAKVWAVKSAEQLSC 2275
                                                         .|.::..|.
pombe  1549 ---------------------------------------------KYHNMILKT----------- 1557

  Fly  2276 FLKHMVKVFADSYPQARIAERWAQTALQLGLSCSSRHYAGRCLQIFRALNVPINSRMLSDILSRL 2340
                 :::.:.|||:  :.:.|.:.||....:|.||..|....|:||:|....::|||.:|:|||
pombe  1558 -----IELLSSSYPE--LKQIWGEVALSWATTCPSRRLACNSFQLFRSLLPDFDARMLLEIISRL 1615

  Fly  2341 VETVAEQGEDMQGYVTELLLTLEAAVDSLDSDFRPLDVMKDIFKSTPNLNNKDGGPNSILPGKKS 2405
            |.|::::...::.|..|:|.|..:.|..::||    |::
pombe  1616 VGTISDETSYLRDYSVEILRTFNSYVLVMNSD----DLL-------------------------- 1650

  Fly  2406 PSGMTPQSSNYSIPSHGRSTSYSVSYCGRKANNSPCDKQVELRNRSSGIDLERSVVCKFGVGGGG 2470
                                |||
pombe  1651 --------------------SYS------------------------------------------ 1653

  Fly  2471 AGSALSRSRSAQSLKMLGDTATQDDKMTILAQLFWLSVSLLESDYEHEFMLALRLLTRVLHRLPL 2535
                                           |:.|.:::.|.:.:|.||:.::::......|:
pombe  1654 -------------------------------QILWTAIACLTTIHEDEFIESVKIAYAYFLRV-- 1685

  Fly  2536 DRPDARDKVEKLQQQL------KWTA-YPGVHALLLKGCTHSATYEPTITLLSQFAPLLTLPVCD 2593
                  ::.:...||:      .|.. |.|:..|:|||...:.::|.|:...     ||.:...|
pombe  1686 ------EETDSATQQIMETFPQNWVGDYQGLQILILKGFRSTNSFEITMNFF-----LLLMDFKD 1739

  Fly  2594 ---------PTQSCAFPMNVIALLPYMLLHYE-------DANEICIRSAENIAQVSTELGAKLEN 2642
                     ...||     ::..||.|:..||       |.:..|.:.|...:|.:.:  |.:|.
pombe  1740 NDLVGVGYLRILSC-----LLVSLPAMVYTYEHSDPITFDLSVFCHKLATLASQFNDD--ALIEL 1797

  Fly  2643 LGTVMTLYSRKTFCKESFQWTKCVVKYLHDTY-AHMGLHMVAFLIEVLEKGPQQVQVPVLNVIHC 2706
            |.|    |.::.| :....:.|..|.||:..| ....|.:|:.|...|.......:...|:|:..
pombe  1798 LDT----YLKRKF-RSIKDFLKHTVSYLYSYYFEDYELEIVSTLTMFLSNNLTWFRKSTLDVLKE 1857

  Fly  2707 MLHYVDLSAPQAQSINADLLRAIGKYLDTAYWKDSLKILK---LIVTRSSSLQ-----VVPP--- 2760
            :...:|...|........::..:.:.|.|.|..::|.:|.   |.|:..:.:|     :|.|
pombe  1858 LFPLIDFQKPIYSEHGLGIVSPLLRLLPTGYAMEALSLLTDSVLHVSAPTDMQTLKLLMVDPKLK 1922

  Fly  2761 -SDGSSAGLSFSFYGAYPDSDMFCKKELAGRTMEFTFDVSQTPLIGRRILLKTEEPVAGGAVSTT 2824
             ||...||     :...||.|.:                              .||
pombe  1923 NSDDRLAG-----FFEIPDEDGW------------------------------YEP--------- 1943

  Fly  2825 GSSSLNSTLTNATTVTVAPSAAQQQTNVQMQQQRANTNVAALAAAAAAQHQQQQHAIGAGSSVVG 2889
                 ||....|.|          ::||.......:|..|:::......|..:
pombe  1944 -----NSEYAAAIT----------KSNVHAVFYSCSTTEASVSTPEVRFHADE------------ 1981

  Fly  2890 TPNSPRRSASLSPADTVPLSGWKRPWMSQCRVRECLVNLLTTCGQRVGLPKSPSSLSTSLLTGSI 2954
            ..|.||.    .|.|                                    |..||..:.|...:
pombe  1982 VSNYPRH----VPTD------------------------------------SHGSLDENSLGELV 2006

  Fly  2955 ATRQS--VIFSQSSDLMERQSSAASSTEETSGPQGDLSSGSRRDDGQPDFTVFKDFDFL--EYED 3015
            .|..|  |.|::..|            ||..               |||..|....|..  :|:|
pombe  2007 TTLHSLDVFFAEDRD------------EELI---------------QPDVAVDPKLDITSEDYDD 2044

  Fly  3016 SIAGESTDNFNWGVRRHQLFEGDEDRLNCGSGIGGSI---KGGHSSAFEDSFSDKTPILSKRKRQ 3077
            .||                           :.:.||:   |.|..:...:||.|.:|
pombe  2045 RIA---------------------------TILSGSLRRQKQGLMAYETESFRDYSP-------- 2074

  Fly  3078 IADDSSDEEAESESPLDEDHRQSFLKSGYSAVPPTSLSLRERRRRNSVSR--------SDTSGSS 3134
                :.:.:|.::.|:|              :||..:     |:.:.:|:        :::...|
pombe  2075 ----NEEIDASAKLPMD--------------MPPVRV-----RKSSFISKLKPHYFMDAESYYPS 2116

  Fly  3135 AGDLGDLTPCNASPHLPGIIRFSAAIHDEAEENWRRQV--QALLVNQPSAHTSELLQQLYRLIKE 3197
            ...||     |::.|...:.....|...:..:||...:  ...::|:.|....|..:..|.|
pombe  2117 LKALG-----NSAEHRLSLDEIRGAAELKQNKNWNSMLDQSVSMINEDSVEDHETHENYYHL--- 2173

  Fly  3198 LTFKTVNISKEAKKFFT 3214
               :|:....|:.:.||
pombe  2174 ---RTMFQGSESNESFT 2187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fry	NP_001246701.1	MOR2-PAG1_N	389..923	CDD:290922	120/554 (22%)
		MOR2-PAG1_mid	1326..2098	CDD:290928	164/833 (20%)
		MOR2-PAG1_C	2501..2753	CDD:290925	58/278 (21%)
mor2	NP_596172.1	MOR2-PAG1_N	128..>468	CDD:290922	90/354 (25%)
		MOR2-PAG1_mid	<1140..>1372	CDD:290928	68/273 (25%)
		MOR2-PAG1_mid	<1481..1601	CDD:290928	43/258 (17%)
		MOR2-PAG1_C	1654..1905	CDD:290925	58/275 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	111	1.000	Domainoid score	I1589
eggNOG	1	0.900	-	-		E1_KOG1825
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I472
OMA	1	1.010	-	-		QHG55726
OrthoFinder	1	1.000	-	-		FOG0001786
OrthoInspector	1	1.000	-	-		oto100762
orthoMCL	1	0.900	-	-		OOG6_102307
Panther	1	1.100	-	-	LDO	PTHR12295
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3991
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.990