|
Fly 220 PVSRQSYASPPALIIPQRQSLLPWGAHSRSSIINVLPSYTQAEMHALAARVASVETSAPRPGEIV 284
||. ..|..|| :|... |.|.......:|| .:|:..: :|||.|
Human 26 PVG-NGYIKPP---VPPAS-----GTHREKGPPTMLP--------------INVDPDS-KPGEYV 66
Fly 285 MRNLFSDFTAQAEKKIELVMLESADKNLSKLLQRGEDQQFDQLLSALGSVAEHCLPSLLHTLLAW 349
:::||.:||.|||:||.::|.|..:|.|:|.||||||.||||::|::.|::|:||||:|.||..|
Human 67 LKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDW 131
Fly 350 HRRQLSDMEIKNDLKKPAPSGSSSQAATNKPTVDLDFQLQRREAAVEFIFCLALIEILKQLPYHP 414
::|| :.:|.::...:|..|..|......: |:.::||:.|::|||.|.|||:|||:|.||
Human 132 YKRQ-NGIEDESHEYRPRTSNKSKSDEQQR-----DYLMERRDLAIDFIFSLVLIEVLKQIPLHP 190
Fly 415 GHEDLVRSIENLAFKHFKYKDGLQNNPNALNIHMIADLYAEVIGVLAQSRFASVRKRFMSELKEL 479
..:.|:..:.||||||||||:|.. .||..|:|::|||||||||||||::|.:|:|:||:|||||
Human 191 VIDSLIHDVINLAFKHFKYKEGYL-GPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKEL 254
Fly 480 RGKEVSPTTTQSIISLLMGMKFFRVKMVPIEEFEASFQFMHECGQYFLEVKDKDIKHALAGLFVE 544
|.||.:|...||||||:|||||||:||.|:|:||||.|||.||..||||||||||||||||||||
Human 255 RHKEQNPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVE 319
Fly 545 ILVPVAAAVKNEVNVPCVKNFVELLYVQTLDASTKSKHRLALFPLVTCLLCVSQKTFFLTNWHYF 609
|||||||||||||||||::||||.||..||:.|::.||.|||:||||||||||||..||..||.|
Human 320 ILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHIF 384
Fly 610 LAMCLSNLKNRDAKMSRVALESLFRLLWVYMIRIKCESNSATHSRLQSIVNSLFPKGSKGVVPRD 674
|..|||||||:|.||:|||||||:|||||||||||||||:||.|||.:|:.:||||||:||||||
Human 385 LNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITIITTLFPKGSRGVVPRD 449
Fly 675 TPLNIFVKIIQFIAQERLDFAMREIVYDLLCVGRSIKLI-LNPERMSIGLRAFLVVADSLQQKAG 738
.|||||||||||||||||||||:||::|.||||:..|.. ||||||:||||||||:|||||||.|
Human 450 MPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDG 514
Fly 739 EPPMPRTVPVLPSGNTLRVKKTFNKMYVLLTDDTARSIGMSTYFPHVRRVFVDILRALDVHYGRP 803
|||||.|..|||||||||||||: :...||::.|:.||||.|:..||:...:|||.||...||.
Human 515 EPPMPVTGAVLPSGNTLRVKKTY--LSKTLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRC 577
Fly 804 LMMTNTQNQNKEPDEMLSGERKPRIDLFRTCVAAVPRLIPDTMTPHELVDMLSRLSVHMDEELRI 868
:|:||.|..||||::|::|||||:||||||||||:|||:||.|:..||:|:|:|||:|||:|||.
Human 578 MMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRH 642
Fly 869 LTHQSLTTLVIDFPDWRQDVVHGYTQFLVRDVTDTYPQLLENCTRILFTFLNIWRCATNVNGNNT 933
:...||..|::||.|||:||:.|:|.||:|:|.|.:..||::..::|...|..|:......|.
Human 643 IAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGK-- 705
Fly 934 TSAPSGATNVVNTSQAKMTTATTTTTVVQATVVQVTSAPAKDTASSQLSKQQHLNTASSAASSIT 998
....|:.|.
Human 706 --------------------------------------------------------VYEQANKIR 714
Fly 999 TSSGMSSITQHTVLNMASDVGKKNEIPLATTLHFVEGFALVLLCNYRTYLRKLAALILKEVKNLM 1063
.|..:::.:.|.: .|:.| |..:.||.||||||||||:::...|||:.|||||::.|.
Human 715 NSELIANGSSHRI---QSERG-----PHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALF 771
Fly 1064 RALGIPETEP-PLIDVMDRCVPGIIEKCLPQLPQTEKTAILNANCIDLQWIAERSSGVWLAGLTD 1127
.|||.||.:. |:|||||:....|:|..:........|..|..| :||||:.| |.|.|.:
Human 772 IALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHN-VDLQWLVE-----WNAVLVN 830
Fly 1128 D--NSKSSTSTLNLSQSSSTPNASATAASSPQLPFDPWATCLFGLLERQNVLQQCPSAVAQAWPI 1190
. :.||.:.....:||.. |||..|||..|.::|:.:.||:|::.|||.
Human 831 SHYDVKSPSHVWIFAQSVK----------------DPWVLCLFSFLRQENLPKHCPTALSYAWPY 879
Fly 1191 CFTRLNALYSVIDP-TPVSDNRASLLRSSAPTKKVPTESQKDSYLRLWRNQ-VACAMRLVPQIPS 1253
.||||.::..::|| :|:: .||..|....|:|:.||||. :.|.....|.|.|
Human 880 AFTRLQSVMPLVDPNSPIN------------AKKTSTAGSGDNYVTLWRNYLILCFGVAKPSIMS 932
Fly 1254 VA-VRCASPDLSLSLQDQSDSRSLSDSLDNIPSNVFGPEGIVTRFTLPLSYGRKEARQKRLGSSP 1317
.. :|.::|::..:. |:|.| ||
Human 933 PGHLRASTPEIMATT----------------------PDGTV-------SY-------------- 954
Fly 1318 DSLNADRSDKSAMGSASPQALYKLVVPLLRCEVVDVRDAAVNALGLINHDALKDLMEELVVYIRE 1382
|..|:|:.|...|.|.:|||:|.|.:::.::.|...|..|....::|:|||...::|
Human 955 --------DNKAIGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKE 1011
Fly 1383 AVDCKQENMRRRRRRDALRLQVVRVLEKIAENGTFGVST-CVLERDTMSLHPTFVLYISGAMGYL 1446
|::.:.||.:||.|||.||||::|:.|.:|:.|....|| ..|||||::|...|:.|:......|
Human 1012 ALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLL 1076
Fly 1447 TSETDKDNLSIREVKAHFCNFIRKMIKNFPLEACATLL-SRVLKRNLFNLFAAWCGSFS---KPL 1507
.:|.||:...:::::|||...:..:|:..|:.....|. .:.|:.:||.||:.|.|.|| .||
Human 1077 EAENDKEVEILKDIRAHFSAMVANLIQCVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPL 1141
Fly 1508 GYTMQSDHTLEEEKLQFSALQAMSALLCCGQIFNPSYLQDDSIIYKWLDMLLTSKNEKIYQLARD 1572
...||...:..:.|:.||:||||:||||.:|:...|..|..:|||||.:|..::.:::||..:
Human 1142 --DRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCE 1204
Fly 1573 TVVLLLESNPDIGQLLEWVIDRCYTSTPREADACFLALASIFSAKEYPCDHYTSVITVTLLMTGC 1637
.||||||.|||...|..|.||||||.:.:.|..||.|:|::..::.||.|..| ::.:.|.....
Human 1205 VVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVT-LLNLVLFKASD 1268
Fly 1638 PRVEVHATALQLLQILDKRFF-----------GSVVGTLHSDSDKEDDKVGTLDVLLSSAYCRSQ 1691
...|::..::||:|||:.:.| ||::...| |.|..| |..|.
Human 1269 TNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTH----------GPLPPL----YSVSL 1319
Fly 1692 RFLSKQLAQLRPELTMSIFSEITHRFQSAREDVRALLLQCLLPWLQNMELVATS--VPPATPLSY 1754
..||.:||::.||||:.:|||::.||.:...:.|.::|..|||||.|:|||.:. :|.::|.|
Human 1320 ALLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSS- 1383
Fly 1755 IMYFPDS-------------GTRGRREGTGSTEATEMILNNLFYITAKFSDAHP-RDIEELWGTL 1805
|:. |.|| .|.||.|||.::||||.|:|||:.|..| .::|..|..|
Human 1384 ----PEDEVKDREGDVTASHGLRG--NGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWNAL 1442
Fly 1806 C--QFWPNNLKVILRYLVIMSGM-APTELLPYAKRVALYLVRSCPDRLLDELMAELQTVETLNCL 1867
. :.|.|||::.|::|:.:.|: :.|.||||.|:||:||.|:...:.::||:.|||..|.:|.:
Human 1443 ANNEKWSNNLRITLQFLISLCGVSSDTVLLPYIKKVAIYLCRNNTIQTMEELLFELQQTEPVNPI 1507
Fly 1868 IERTETPPFYRLTSMRKASSHSADGQAAGGINDSRIQDLAVEKGTIHTKRHSGEDP-----MKIG 1927
::..:.|||||.|:..|||: ||.|...| ..|:...:.:..|. :|..
Human 1508 VQHCDNPPFYRFTASSKASA------AASGTTSS--------SNTVVAGQENFPDAEENKILKES 1558
Fly 1928 TCKSDSGIRAYTQAAAAAAAAAVTPGSSGNRPPRGADKIRAASGPSILPRPEDILINDPELRQEE 1992
..:..:.|||:|: ..:..:..|.|:......|.|...:| .|:...|.:|
Human 1559 DERFSNVIRAHTR-----LESRYSNSSGGSYDEDKNDPISPYTG---------WLLTITETKQ-- 1607
Fly 1993 NVELRGTSDAAPNGHPHPLPMPEYGGYFAPLTEFLPDVSLPISGFHRCNVAVMLLTDIVVDGIPG 2057
|.|||||..||.:|||.::||:...|....||||:||:.:|::|||....
Human 1608 ---------------PQPLPMPCTGGCWAPLVDYLPETITPRGPLHRCNIAVIFMTEMVVDHSVR 1657
Fly 2058 IDWTLHLPLMLHILFLGLDHTRIIVREHCKQLCVNLLIVLAEHNDHLTVARILLNSETSKLDLGL 2122
.||.|||||:||.:||||||.|..|.||.|:|.::|||.|:.:::..::|.:|| :|.::....
Human 1658 EDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHSIASVLL--QTREMGEAK 1720
Fly 2123 TVPALP------VIDNNFTELHQQFDSYLLHVSPQAAAYALQHNLSSSTIIAAHHQNLSQTPQSQ 2181
|:...| :....|..|.:. ..||...:.....:.|||..:.....|| ||..
Human 1721 TLTVQPAYQPEYLYTGGFDFLRED------QSSPVPDSGLSSSSTSSSISLGGSSGNL---PQMT 1776
Fly 2182 QQTGSQNGQTTTPPGLTATPAALQINPNNSENSEVPLIHPDEHAPPQPGPSMPIAHVIKSLLKFL 2246
|:....:....| ||.| ..|::||
Human 1777 QEVEDVDTAAET----------------------------DEKA--------------NKLIEFL 1799
Fly 2247 AQDTCQPLWNYEDITAKVWAVKSAEQLSCFLKHMVKVFADSYPQARIAERWAQTALQLGLSCSSR 2311
......|||.:||||.|....||||||:.||:|:|.||.||.....:..:.::.|||..|:.|||
Human 1800 TTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFKDSKSGFHLEHQLSEVALQTALASSSR 1864
Fly 2312 HYAGRCLQIFRALNVPINSRMLSDILSRLVETVAEQGEDMQGYVTELLLTLEAAVDSLDSDFRPL 2376
|||||..||||||..|:::..|||:||||||.:.|.|:::||||.|.|||||||||:|....:..
Human 1865 HYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNS 1929
Fly 2377 DVMKDIFK-STPNLNN--------KDGGPNSILPGKKSPSGMTPQSSNYSIPSHGRSTSYSVSYC 2432
|::..:.: |:|:|:: |..|..::.||..|.:..|.:.|. |.| |:||
Human 1930 DLLTVLSRSSSPDLSSSSKLTASRKSTGQLNMNPGTTSGNTATAERSR-----HQR--SFSV--- 1984
Fly 2433 GRKANNSPCDKQVELRNRSS----GIDLERSVVC-KFGVGGGGAGSALSRSRSAQSLK-MLGDTA 2491
.|:..:.:||| ...|:|...| :.|:. |::||:.||| .|.|.:
Human 1985 ---------PKKFGVIDRSSDPPRSATLDRIQACTQQGLS--------SKTRSSSSLKDSLTDPS 2032
Fly 2492 TQDDKMTILAQLFWLSVSLLESDYEHEFMLALRLLTRVLHRLPLDRPDARDKVEKLQQQLKWTAY 2556
..:....:||.:||::|:|:|||:|.|:::|||||:|:|..:|||:.:.|:|:||||.||||..:
Human 2033 HINHPTNLLATIFWVTVALMESDFEFEYLMALRLLSRLLAHMPLDKAENREKLEKLQAQLKWADF 2097
Fly 2557 PGVHALLLKGCTHSATYEPTITLLSQFAPLLTLPVCDPTQSCAFPMNVIALLPYMLLHYEDANEI 2621
.|:..|||||.|...|.:.|:.|.|...|:..:.:.|.:.:..||:||:.|||.::.|:|:.|:.
Human 2098 SGLQQLLLKGFTSLTTTDLTLQLFSLLTPVSKISMVDASHAIGFPLNVLCLLPQLIQHFENPNQF 2162
Fly 2622 CIRSAENIAQVS-TELGAKLENLGTVMTLYSRKTFCKESFQWTKCVVKYLHDTYAHMGLHMVAFL 2685
|...||.||||. .|...||.||..|||||...::.::...|...|.:|||:.||.:.|:||.:|
Human 2163 CKDIAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADITLNMVTYL 2227
Fly 2686 IEVLEKGPQQVQVPVLNVIHCMLHYVDLSAPQAQSINADLLRAIGKYLDTAYWKDSLKILKLIVT 2750
.|:||||...||.|:|.||:.:|.|:|||....:..|.::|:.|.||:.:.:|:::|.||||:|:
Human 2228 AELLEKGLPSVQQPLLQVIYSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSVHWREALNILKLVVS 2292
Fly 2751 RSSSLQVVPPSDGSSAGLSFSFYGAYPDSDM----------FCKKELAGRTMEFTFDVSQTPLIG 2805
||:|| |:| :|..||: ...|||.|:|::|.||:|:||:||
Human 2293 RSASL-VLP---------------SYQHSDLSKIEIHRVWTSASKELPGKTLDFHFDISETPIIG 2341
Fly 2806 RRILLKTEEPVAGGAVSTTGSSSLNSTLTNATTVTVAPSAAQQQTNVQMQQQRANTNVAALAAAA 2870
||. ..|.|::.....|.| |...|:.::.::
Human 2342 RRY----------------------DELQNSSGRDGKPRA--------MAVTRSTSSTSS----- 2371
Fly 2871 AAQHQQQQHAIGAGSSVVGTPNSPRRSASLSPADTVPLSGWKRPWMSQCRVRECLVNLLTTCGQR 2935
|:.|:|: ||:| ||||..||.|.:|.||::|:.|||.
Human 2372 -----------GSNSNVL-----------------VPVS-WKRPQYSQKRTKEKLVHVLSLCGQE 2407
Fly 2936 VGLPKSPSSLSTSLLTGSIATRQSVIFSQSS--DLMERQSSAASSTEETSGPQGDLSSGSRRDDG 2998
|||.|:| |||||... ||:|.|:|..||.: |:|..:.
Human 2408 VGLSKNP----------------SVIFSSCGDLDLLEHQTSLVSSED-----------GAREQEN 2445
Fly 2999 QPD------FTVFKDFDFLEYE----DSIAGESTDNFNWGVRRHQLFEGDEDRLNCGSGIGGSIK 3053
..| |.||:|||||:.| :.:.|||.|||||||||..|...|: |...|
Human 2446 MDDTNSEQQFRVFRDFDFLDVELEDGEELQGESMDNFNWGVRRRSLDSLDK----CDMQI----- 2501
Fly 3054 GGHSSAFEDSFSDKTPILSKRKRQIADDSSDEE-------------------AESESPLD----- 3094
..|...|..||.|:|...:.:|:||:|| :|..:|::
Human 2502 -----LEERQLSGSTPSLNKMHHEDSDESSEEEDLTASQILEHSDLIMTLSPSEETNPMELLTTA 2561
Fly 3095 ------EDHRQSFLKSGYSAVPP--TSLSLRE-------RRRRNSVSRSDTSGSSAGDLGDLTPC 3144
|.|..:...|.:.|..| .:|.:.| |...::....|...||..:|.....|
Human 2562 CDSTPAEPHSFNTRMSSFDASLPDMNNLQISEGSKAEAVREEEDTTVHEDDLSSSINELPAAFEC 2626
Fly 3145 N------------------------------------ASPHLPGII-RFSAAIHDEAEENWRRQV 3172
: .||....|: .|..|..|:|||.||..:
Human 2627 SDSFSLDMTEGEEKGNRALDQFTLASFGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHI 2691
Fly 3173 QALLVNQP---SAHTSELLQQLYRLI-KELTFKTVNISKEAKKFFTGIGSQLGNRISLFTDLLSS 3233
..|:.:.. :.:|..:...|::.| |...|.|.:.:........||||:..:. :.:|:|
Human 2692 NQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSS----SQMLTS 2752
Fly 3234 RADPPQVWCSELQATSPKLFETLRFNVLEVQEHLETFFDRKDQVLECLDAVKTSCKLSLFNEADV 3298
.::.|.::.......|..|.:.|:|:|||:||:|:|:.:||:..|..| .:||.:. |..
Human 2753 CSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWL----ANCKATF---AGG 2810
Fly 3299 AASGLELPSTSSIVYMPFDPASTEV----VLDLGRSLYKLMFQLLLLIESNHKISSNVVNHFRMN 3359
:..|: |...|.|....:: .|:|.:.||||.||||||.:|..|:...|
Human 2811 SRDGV-------ITCQPGDSEEKQMESLAQLELCQRLYKLHFQLLLLFQSYCKLIGQV------- 2861
Fly 3360 EDMHDISDLYALVRDALVRYISEAELDCLESSTSTEGEHTPTPSPGLPMTP--EEFEAVLTEHID 3422
|::|.:..|:. :.|.:|:.:....|:|.....: |..|.|....| ...||.:...::
Human 2862 ---HEVSSMPELLN--MSRELSDLKKHLKEASAVIAAD--PLYSDGAWSEPTFTSTEAAIQSMLE 2919
Fly 3423 LQRWPSAIAHVRQYRRISTLNASGYQNVTIFSYNSADNRQKWDEISVILNAYAHGIMKDRTAEAF 3487
..:.......:||.|...:| :.| .||. :|:| ||:..:||.|.......:|....
Human 2920 CLKNNELGKALRQIRECRSL----WPN-DIFG-SSSD-----DEVQTLLNIYFRHQTLGQTGTYA 2973
Fly 3488 IVSKSDSEVFEIYAILSENLYQVSSALTNMEI-----SMKSYSA-------GSASGNS 3533
:|. |:..:.||...|.| .|||| ..:||.. .|.||.|
Human 2974 LVG-SNQSLTEICTKLME---------LNMEIRDMIRRAQSYRVLTTFLPDSSVSGTS 3021
| 
