DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8336 and PPIL4

DIOPT Version :9

Sequence 1:	NP_001261636.1	Gene:	CG8336 / 39121	FlyBaseID:	FBgn0036020	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_624311.1	Gene:	PPIL4 / 85313	HGNCID:	15702	Length:	492	Species:	Homo sapiens

Alignment Length:	344	Identity:	78/344 - (22%)
Similarity:	132/344 - (38%)	Gaps:	100/344 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GRMIIELRKDVVPKTAENFRALCTGECGIGTLGKPLHYKGTKFHKIKRVFVVQSGDVVKNDGSSG 93
            |.::|:|..:..|:...||..||          |..:|.....|.::|.|::|:||.. ..|..|
Human    10 GDVVIDLYTEERPRACLNFLKLC----------KIKYYNYCLIHNVQRDFIIQTGDPT-GTGRGG 63

  Fly    94 ESIYGPVFDDEN--FE------LSHNEEGVVSMANYGKPNSNNSQFFISAAGCEN---LNGTNVV 147
            |||:|.::.|:.  ||      :.|.::|.|||.|.|. :.:.|||.|:..  ||   |:|.:.|
Human    64 ESIFGQLYGDQASFFEAEKVPRIKHKKKGTVSMVNNGS-DQHGSQFLITTG--ENLDYLDGVHTV 125

  Fly   148 VGRVLRGLGIVAEMEQNCTDEG-------------------DPTAPIVIRDCGEIAHNEDWGIEC 193
            .|.|..|:.|:.::.:...|:.                   |....::|.|            ..
Human   126 FGEVTEGMDIIKKINETFVDKDFVPYQDIRINHTVILDDPFDDPPDLLIPD------------RS 178

  Fly   194 NDETTDKLPAYPQDWPRKLDKFTGDGAVELLTGIRQSGNHFYQLGRYHEARAKYRKANRYYHYLS 258
            .:.|.::|.:.......::|.|.|..|.|:                 .|.:|:  |..:....|.
Human   179 PEPTREQLDSGRIGADEEIDDFKGRSAEEV-----------------EEIKAE--KEAKTQAILL 224

  Fly   259 RQFG---------------WQQLNPLKKHLVDEDLLKVDGFSVVNNINAAAVDLKVGNYTSAREV 308
            ...|               ..:|||:   ..||||..:  ||....|.:..|   :.::.:...:
Human   225 EMVGDLPDADIKPPENVLFVCKLNPV---TTDEDLEII--FSRFGPIRSCEV---IRDWKTGESL 281

  Fly   309 CNEAIRLDPK--CSKAFYR 325
            |...|..:.:  |.|||::
Human   282 CYAFIEFEKEEDCEKAFFK 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8336	NP_001261636.1	cyclophilin	15..181	CDD:294131	49/181 (27%)
		TPR repeat	285..315	CDD:276809	5/29 (17%)
		TPR_19	300..369	CDD:291240	6/28 (21%)
		TPR_1	320..353	CDD:278916	3/6 (50%)
		TPR repeat	320..346	CDD:276809	3/6 (50%)
PPIL4	NP_624311.1	cyclophilin_RRM	4..161	CDD:238902	46/164 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..188		5/32 (16%)
		RRM_PPIL4	237..319	CDD:240681	17/72 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900