DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8336 and SQN

DIOPT Version :9

Sequence 1:	NP_001261636.1	Gene:	CG8336 / 39121	FlyBaseID:	FBgn0036020	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_565381.1	Gene:	SQN / 816074	AraportID:	AT2G15790	Length:	361	Species:	Arabidopsis thaliana

Alignment Length:	380	Identity:	149/380 - (39%)
Similarity:	209/380 - (55%)	Gaps:	41/380 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 YLDISIGKEDAGRMIIELRKDVVPKTAENFRALCTGECGIG-TLGKPLHYKGTKFHKIKRVFVVQ 81
            ::|||||.|..||::|||..|||||||||||.|||||.|:| ..|.||||||.:||::.:.|::|
plant     7 FMDISIGGELEGRIVIELYDDVVPKTAENFRLLCTGEKGLGPNTGVPLHYKGNRFHRVIKGFMIQ 71

  Fly    82 SGDVVKNDGSSGESIYGPVFDDENFELSHNEEGVVSMANYGKPNSNNSQFFISAAGCENLNGTNV 146
            .||:..|||:.||||||..||||||||.|..:|::||||.| ||:|.|||||:.....:|:|.:|
plant    72 GGDISANDGTGGESIYGLKFDDENFELKHERKGMLSMANSG-PNTNGSQFFITTTRTSHLDGKHV 135

  Fly   147 VVGRVLRGLGIVAEM------EQNCTDEGDPTAPIVIRDCGEIAHNEDWGIECNDETTDKLPAYP 205
            |.|||.:|:|:|..:      ||:|     |:..:||.|||||....|.|| | |...|. ..||
plant   136 VFGRVTKGMGVVRSIEHVSIEEQSC-----PSQDVVIHDCGEIPEGADDGI-C-DFFKDG-DVYP 192

  Fly   206 QDWPRKLDKFTGDGA--VELLTGIRQSGNHFYQLGRYHEARAKYRKANRYYHYLSRQFGWQQLNP 268
             |||..|::...:.:  :|.:..::..||..::...|..|..|||||.||.     ...|:
plant   193 -DWPIDLNESPAELSWWMETVDFVKAHGNEHFKKQDYKMALRKYRKALRYL-----DICWE---- 247

  Fly   269 LKKHLVDEDL------LKVDGFSVVNNINAAAVDLKVGNYTSAREVCNEAIRLDPKCSKAFYRRA 327
              |..:||:.      .|...|:     |:||..||.|:...|......|:|.:....||.:|:.
plant   248 --KEGIDEETSTALRKTKSQIFT-----NSAACKLKFGDAKGALLDTEFAMRDEDNNVKALFRQG 305

  Fly   328 QAQRGLRNYEEAINDLKTAHNLLPENKQILNELNSTKQLLAQYNRQQRNALKNLF 382
            ||...|.|.:.|...|:.|....|.:..|..|..:..:.:|..:.:::...:.:|
plant   306 QAYMALNNVDAAAESLEKALQFEPNDAGIKKEYAAVMKKIAFRDNEEKKQYRKMF 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8336	NP_001261636.1	cyclophilin	15..181	CDD:294131	91/169 (54%)
		TPR repeat	285..315	CDD:276809	8/29 (28%)
		TPR_19	300..369	CDD:291240	17/68 (25%)
		TPR_1	320..353	CDD:278916	11/32 (34%)
		TPR repeat	320..346	CDD:276809	9/25 (36%)
SQN	NP_565381.1	cyclophilin_ABH_like	4..171	CDD:238907	91/169 (54%)
		TPR_11	216..329	CDD:290150	36/128 (28%)
		TPR repeat	263..293	CDD:276809	10/34 (29%)
		TPR_2	298..331	CDD:285020	11/32 (34%)
		TPR repeat	298..326	CDD:276809	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31283
Inparanoid	1	1.050	228	1.000	Inparanoid score	I1154
OMA	1	1.010	-	-		QHG53622
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	1	1.000	-	-		oto2812
orthoMCL	1	0.900	-	-		OOG6_103831
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740