DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8336 and ppil4

DIOPT Version :9

Sequence 1:	NP_001261636.1	Gene:	CG8336 / 39121	FlyBaseID:	FBgn0036020	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001121802.1	Gene:	ppil4 / 554886	ZFINID:	ZDB-GENE-030131-6251	Length:	454	Species:	Danio rerio

Alignment Length:	340	Identity:	78/340 - (22%)
Similarity:	134/340 - (39%)	Gaps:	92/340 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GRMIIELRKDVVPKTAENFRALCTGECGIGTLGKPLHYKGTKFHKIKRVFVVQSGDVVKNDGSSG 93
            |.::|:|..:..||.:.||..||          |..:|.....|.::|.|::|:||.. ..|..|
Zfish    10 GDIVIDLYTEERPKASLNFLKLC----------KIKYYNYCLIHNVQRDFIIQTGDPT-GTGRGG 63

  Fly    94 ESIYGPVFDDEN--FE------LSHNEEGVVSMANYGKPNSNNSQFFISAAGCEN---LNGTNVV 147
            ||::..::.|:.  ||      :.|.::|.|||.|.|. :.:.|||.|:..  ||   |:|.:.|
Zfish    64 ESVFCKLYGDQARFFESEKMPRIKHRKKGTVSMVNNGS-DQHGSQFLITTG--ENVDYLDGVHTV 125

  Fly   148 VGRVLRGLGIVAEMEQNCTDE--------------------GDPTA-PIVIR---------DCGE 182
            .|.|..|:.::|::.:...|.                    .||.. |:..|         |.|.
Zfish   126 FGEVTEGMDVLAKINETFVDNDFIPFQDIRINHTVILDDPFDDPAGLPVPDRSPEPTKQQLDSGR 190

  Fly   183 IAHNEDWGIECNDETTDKLPAYPQDWPRKLDKFTGDGAVELLTGIRQSGNHFYQLGRYHEARAKY 247
            |..:|...   :||..|         |.:||:...|...:....:.:      .:|...:|..|.
Zfish   191 IGADEAIN---DDEGKD---------PEELDELIKDKEAKTQAILLE------MVGDLPDADIKP 237

  Fly   248 RKANRYYHYLSRQFGWQQLNPLKKHLVDEDLLKVDGFSVVNNINAAAVDLKVGNYTSAREVCNEA 312
            .:...:.         .:|||:   ..||||..:  ||....|....:   :.::.:...:|...
Zfish   238 PENVLFV---------CKLNPV---TTDEDLEII--FSRFGLIKCCEI---IRDWKTGESLCYAF 285

  Fly   313 IRLDPK--CSKAFYR 325
            |..:.:  |.||:::
Zfish   286 IEFEKEEDCEKAYFK 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8336	NP_001261636.1	cyclophilin	15..181	CDD:294131	50/192 (26%)
		TPR repeat	285..315	CDD:276809	4/29 (14%)
		TPR_19	300..369	CDD:291240	5/28 (18%)
		TPR_1	320..353	CDD:278916	2/6 (33%)
		TPR repeat	320..346	CDD:276809	2/6 (33%)
ppil4	NP_001121802.1	cyclophilin_RRM	4..169	CDD:238902	45/172 (26%)
		RRM	172..>320	CDD:223796	31/164 (19%)
		RRM_PPIL4	237..319	CDD:240681	15/81 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810