DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8336 and PPID

DIOPT Version :9

Sequence 1:	NP_001261636.1	Gene:	CG8336 / 39121	FlyBaseID:	FBgn0036020	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_005029.1	Gene:	PPID / 5481	HGNCID:	9257	Length:	370	Species:	Homo sapiens

Alignment Length:	373	Identity:	148/373 - (39%)
Similarity:	220/373 - (58%)	Gaps:	18/373 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TNPLVYLDISIGKEDAGRMIIELRKDVVPKTAENFRALCTGECGIG-TLGKPLHYKGTKFHKIKR 76
            :||.|:.|:.||.|..||:::||..|:|||||||||||||||.||| |.|||||:||..||:|.:
Human    14 SNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIK 78

  Fly    77 VFVVQSGDVVKNDGSSGESIYGPVFDDENFELSHNEEGVVSMANYGKPNSNNSQFFISAAGCENL 141
            .|::|.||....:|:.||||||..|:||||...|:.||::||||.|: |:|.|||||:.....:|
Human    79 KFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGR-NTNGSQFFITTVPTPHL 142

  Fly   142 NGTNVVVGRVLRGLGIVAEMEQNCTDEGDPTAPI-VIRDCGEIAHNEDWGIECNDETTDKLPAYP 205
            :|.:||.|:|::|:| ||.:.:|...:|:..|.: ||.:|||:...:|.||...|.:.|..|.:|
Human   143 DGKHVVFGQVIKGIG-VARILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFP 206

  Fly   206 QDWPRKLDKFTGDGAVELLTGIRQSGNHFYQLGRYHEARAKYRKANRYYHYLSRQFGWQQLNPLK 270
            :|  ..:|....|..:.:...::..||.|::...:..|..||.:..||            ::..|
Human   207 ED--ADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRY------------VDSSK 257

  Fly   271 KHLVDEDLLKVDGFSVVNNINAAAVDLKVGNYTSAREVCNEAIRLDPKCSKAFYRRAQAQRGLRN 335
            ..:...|..|:...::...:|..|..||:.|:..|.:.|.||:.|||..:||.|||||..:||:.
Human   258 AVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKE 322

  Fly   336 YEEAINDLKTAHNLLPENKQILNELNSTKQLLAQYNRQQRNALKNLFA 383
            |::|:.|||.|..:.||:|.|..||...||.:.....:::.....:||
Human   323 YDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8336	NP_001261636.1	cyclophilin	15..181	CDD:294131	86/167 (51%)
		TPR repeat	285..315	CDD:276809	9/29 (31%)
		TPR_19	300..369	CDD:291240	31/68 (46%)
		TPR_1	320..353	CDD:278916	16/32 (50%)
		TPR repeat	320..346	CDD:276809	14/25 (56%)
PPID	NP_005029.1	cyclophilin_ABH_like	16..182	CDD:238907	86/167 (51%)
		Chaperone activity. /evidence=ECO:0000250	185..215		9/31 (29%)
		PLN03088	192..>362	CDD:330826	54/183 (30%)
		Interaction with HSP90AB1. /evidence=ECO:0000250	214..370		47/167 (28%)
		TPR repeat	224..267	CDD:276809	10/54 (19%)
		TPR repeat	272..302	CDD:276809	9/29 (31%)
		TPR repeat	307..333	CDD:276809	14/25 (56%)
		TPR repeat	341..364	CDD:276809	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11530
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31283
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3101
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53622
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	1	1.000	-	-		oto91639
orthoMCL	1	0.900	-	-		OOG6_103831
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740