DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8336 and PPIL3

DIOPT Version :9

Sequence 1:	NP_001261636.1	Gene:	CG8336 / 39121	FlyBaseID:	FBgn0036020	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_115861.1	Gene:	PPIL3 / 53938	HGNCID:	9262	Length:	165	Species:	Homo sapiens

Alignment Length:	161	Identity:	56/161 - (34%)
Similarity:	80/161 - (49%)	Gaps:	21/161 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DAGRMIIELRKDVVPKTAENFRALCTGECGI-----GTLGKPLHYKGTKFHKIKRVFVVQSGDVV 86
            |.|.:.||:..:..|||.| ..:.|..:.|:     |:|..|.       ...|:||.:.    :
Human     8 DVGDIKIEVFCERTPKTCE-MESRCVPQAGVQWRDLGSLQPPP-------PGFKQVFCLS----L 60

  Fly    87 KNDGSSGESIYGPVFDDENFE-LSHNEEGVVSMANYGKPNSNNSQFFISAAGCENLNGTNVVVGR 150
            ...|..|.||:|..|:||..| |.||..|||||||.| ||:|.|||||:.....:|:....|.|:
Human    61 PRTGRGGNSIWGKKFEDEYSEYLKHNVRGVVSMANNG-PNTNGSQFFITYGKQPHLDMKYTVFGK 124

  Fly   151 VLRGLGIVAEMEQNCTDEGD--PTAPIVIRD 179
            |:.||..:.|:|:...:|..  |...:.|:|
Human   125 VIDGLETLDELEKLPVNEKTYRPLNDVHIKD 155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8336	NP_001261636.1	cyclophilin	15..181	CDD:294131	56/161 (35%)
		TPR repeat	285..315	CDD:276809
		TPR_19	300..369	CDD:291240
		TPR_1	320..353	CDD:278916
		TPR repeat	320..346	CDD:276809
PPIL3	NP_115861.1	cyclophilin	1..158	CDD:294131	56/161 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810