DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8336 and NKTR

DIOPT Version :9

Sequence 1:	NP_001261636.1	Gene:	CG8336 / 39121	FlyBaseID:	FBgn0036020	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001336053.1	Gene:	NKTR / 4820	HGNCID:	7833	Length:	1463	Species:	Homo sapiens

Alignment Length:	267	Identity:	90/267 - (33%)
Similarity:	137/267 - (51%)	Gaps:	24/267 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PLVYLDISIGKEDAGRMIIELRKDVVPKTAENFRALCTGECGIG-TLGKPLHYKGTKFHKIKRVF 78
            |..:.||.|.:|..||::.:|..|:.|||.:||..||:||.|:| |.||.|.|||:.||::.:.|
Human     7 PQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKNF 71

  Fly    79 VVQSGDVVKNDGSSGESIYGPVFDDENFELSHNEEGVVSMANYGKPNSNNSQFFISAAGCENLNG 143
            ::|.||..:.:|..||||||..|.||||.|.|:...::||||.|| ::|.|||||:.....:|:|
Human    72 MIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGK-HTNGSQFFITTKPAPHLDG 135

  Fly   144 TNVVVGRVLRGLGIVAEMEQNCTDEGD-PTAPIVIRDCGEIAHNEDWGIECNDETTDKLPAYPQD 207
            .:||.|.|:.|..::.::|...||... |.|.:.:.|||.:|..   .|:...|...|.|.:.:.
Human   136 VHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATK---SIKDVFEKKRKKPTHSEG 197

  Fly   208 WPRKLDKFTGDGAVELLTGIRQSG----NHFYQLGRYHEARAKYRKANRYYHYLSRQFGWQQLNP 268
                     .|.:....:....|.    .|.....|.|:.|.|.:::.:     .|:.......|
Human   198 ---------SDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKK-----RRKEASSSEEP 248

  Fly   269 LKKHLVD 275
            ..||.::
Human   249 RNKHAMN 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8336	NP_001261636.1	cyclophilin	15..181	CDD:294131	72/167 (43%)
		TPR repeat	285..315	CDD:276809
		TPR_19	300..369	CDD:291240
		TPR_1	320..353	CDD:278916
		TPR repeat	320..346	CDD:276809
NKTR	NP_001336053.1	cyclophilin	7..174	CDD:320812	72/167 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..591		13/83 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..627
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..1072
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1169..1215
		Arg/Ser tandem repeat-rich	1311..1348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750