DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8336 and Ppid

DIOPT Version :9

Sequence 1:	NP_001261636.1	Gene:	CG8336 / 39121	FlyBaseID:	FBgn0036020	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001004279.1	Gene:	Ppid / 361967	RGDID:	1303174	Length:	370	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	149/374 - (39%)
Similarity:	220/374 - (58%)	Gaps:	18/374 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 STNPLVYLDISIGKEDAGRMIIELRKDVVPKTAENFRALCTGECGIG-TLGKPLHYKGTKFHKIK 75
            |.||.|:.|:.||.|..||:::||..|:|||||||||||||||.|.| |.|||||:||..||:|.
  Rat    13 SKNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGTGPTTGKPLHFKGCPFHRII 77

  Fly    76 RVFVVQSGDVVKNDGSSGESIYGPVFDDENFELSHNEEGVVSMANYGKPNSNNSQFFISAAGCEN 140
            :.|::|.||....:|:.||||||..|:||||...|:.||::||||.| ||:|.|||||:.....:
  Rat    78 KKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAG-PNTNGSQFFITTVPTPH 141

  Fly   141 LNGTNVVVGRVLRGLGIVAEMEQNCTDEGDPTAPI-VIRDCGEIAHNEDWGIECNDETTDKLPAY 204
            |:|.:||.|:|::||| ||.|.:|....|:..|.: ||.:|||:...::|||...|.:.|..|.:
  Rat   142 LDGKHVVFGQVIKGLG-VARMLENVEVNGEKPAKLCVIAECGELKEGDEWGIFPKDGSGDSHPDF 205

  Fly   205 PQDWPRKLDKFTGDGAVELLTGIRQSGNHFYQLGRYHEARAKYRKANRYYHYLSRQFGWQQLNPL 269
            |:|  ..:|....|..:.:...::..||.|::...:..|..||.|..||            |:..
  Rat   206 PED--ADIDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYAKVLRY------------LDSS 256

  Fly   270 KKHLVDEDLLKVDGFSVVNNINAAAVDLKVGNYTSAREVCNEAIRLDPKCSKAFYRRAQAQRGLR 334
            |..:...|:.::...::...:|..|..||:.|:..|.:.|.||:.:||..:||.||:||..:||:
  Rat   257 KAVIEKADVSRLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALEMDPSNTKALYRKAQGWQGLK 321

  Fly   335 NYEEAINDLKTAHNLLPENKQILNELNSTKQLLAQYNRQQRNALKNLFA 383
            .|::|:.|||.|..:.|.:|.|..||...||::.....:::.....:||
  Rat   322 EYDQALADLKKAQEIAPGDKAIQAELLKVKQMIKAQKDKEKAVYAKMFA 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8336	NP_001261636.1	cyclophilin	15..181	CDD:294131	88/167 (53%)
		TPR repeat	285..315	CDD:276809	9/29 (31%)
		TPR_19	300..369	CDD:291240	28/68 (41%)
		TPR_1	320..353	CDD:278916	15/32 (47%)
		TPR repeat	320..346	CDD:276809	13/25 (52%)
Ppid	NP_001004279.1	cyclophilin_ABH_like	16..182	CDD:238907	88/167 (53%)
		Chaperone activity. /evidence=ECO:0000250	185..215		9/31 (29%)
		3a0801s09	192..>330	CDD:273380	41/151 (27%)
		Interaction with HSP90AB1. /evidence=ECO:0000250	214..370		45/167 (27%)
		TPR repeat	223..251	CDD:276809	7/27 (26%)
		TPR repeat	272..302	CDD:276809	9/29 (31%)
		TPR repeat	307..335	CDD:276809	14/27 (52%)
		TPR repeat	341..364	CDD:276809	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11484
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31283
Inparanoid	1	1.050	267	1.000	Inparanoid score	I2956
OMA	1	1.010	-	-		QHG53622
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	1	1.000	-	-		otm46359
orthoMCL	1	0.900	-	-		OOG6_103831
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3406
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.740